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The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
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title
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
(English)
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PubMed
author name string
Nicholas Jette
series ordinal
1
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Susan P. Lees-Miller
series ordinal
2
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language of work or name
English
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PubMed
publication date
March 2015
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PubMed
published in
Progress in Biophysics and Molecular Biology
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PubMed
volume
117
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PubMed
issue
2-3
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PubMed
page(s)
194-205
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PubMed
cites work
Beyond DNA repair: DNA-PK function in cancer
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PubMed Central
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20 March 2017
DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3
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PubMed Central
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20 March 2017
mTOR kinase structure, mechanism and regulation
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PubMed Central
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20 March 2017
Structure of the Catalytic Region of DNA Ligase IV in Complex with an Artemis Fragment Sheds Light on Double-Strand Break Repair
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PubMed Central
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20 March 2017
The spindle assembly checkpoint
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PubMed Central
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20 March 2017
Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs
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PubMed Central
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20 March 2017
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair
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20 March 2017
Systematic and quantitative assessment of the ubiquitin-modified proteome
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PubMed Central
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20 March 2017
XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair
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PubMed Central
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20 March 2017
Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2
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PubMed Central
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20 March 2017
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
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PubMed Central
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20 March 2017
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis
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PubMed Central
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20 March 2017
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
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PubMed Central
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20 March 2017
Emerging common themes in regulation of PIKKs and PI3Ks
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PubMed Central
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20 March 2017
Lysine acetylation targets protein complexes and co-regulates major cellular functions
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PubMed Central
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20 March 2017
A role of DNA-PK for the metabolic gene regulation in response to insulin
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PubMed Central
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20 March 2017
Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains
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PubMed Central
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20 March 2017
Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs
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PubMed Central
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20 March 2017
DNA-PK autophosphorylation facilitates Artemis endonuclease activity
1 reference
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PubMed Central
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20 March 2017
The leucine rich region of DNA-PKcs contributes to its innate DNA affinity.
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PubMed Central
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20 March 2017
The DNA-dependent protein kinase catalytic subunit phosphorylation sites in human Artemis
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PubMed Central
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20 March 2017
Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV
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PubMed Central
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20 March 2017
Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase
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PubMed Central
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20 March 2017
Autophosphorylation of the catalytic subunit of the DNA-dependent protein kinase is required for efficient end processing during DNA double-strand break repair
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PubMed Central
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20 March 2017
The protein kinase complement of the human genome
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PubMed Central
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20 March 2017
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase
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PubMed Central
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20 March 2017
Synapsis of DNA ends by DNA-dependent protein kinase
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PubMed Central
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20 March 2017
Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
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20 March 2017
Geometry of a complex formed by double strand break repair proteins at a single DNA end: recruitment of DNA-PKcs induces inward translocation of Ku protein
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PubMed Central
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20 March 2017
Mapping of protein-protein interactions within the DNA-dependent protein kinase complex
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PubMed Central
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20 March 2017
The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
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PubMed Central
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20 March 2017
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
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PubMed Central
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20 March 2017
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
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PubMed Central
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20 March 2017
DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45
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PubMed Central
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20 March 2017
A single ataxia telangiectasia gene with a product similar to PI-3 kinase
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PubMed Central
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20 March 2017
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product
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PubMed Central
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20 March 2017
Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome
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20 March 2017
A DNA-activated protein kinase from HeLa cell nuclei
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20 March 2017
Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination
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20 March 2017
Factors determining DNA double-strand break repair pathway choice in G2 phase
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20 March 2017
The response to and repair of RAG-mediated DNA double-strand breaks
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20 March 2017
DNA-PK: the means to justify the ends?
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20 March 2017
The mechanism of human nonhomologous DNA end joining
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20 March 2017
Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit
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20 March 2017
DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect
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20 March 2017
Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.
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20 March 2017
Dysfunctional mammalian telomeres join with DNA double-strand breaks
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20 March 2017
Enhanced phosphorylation of p53 by ATM in response to DNA damage
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20 March 2017
The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen
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20 March 2017
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
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7 April 2017
PIKKs--the solenoid nest where partners and kinases meet
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29 September 2017
Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4
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29 September 2017
ATR mediates a checkpoint at the nuclear envelope in response to mechanical stress
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29 September 2017
Polo-like kinase 1 (PLK1) and protein phosphatase 6 (PP6) regulate DNA-dependent protein kinase catalytic subunit (DNA-PKcs) phosphorylation in mitosis
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PubMed Central
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29 September 2017
ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint
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29 September 2017
Mitosis inhibits DNA double-strand break repair to guard against telomere fusions
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PubMed Central
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29 September 2017
Non-homologous end joining: emerging themes and unanswered questions
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29 September 2017
Interplay between the DNA damage proteins MDC1 and ATM in the regulation of the spindle assembly checkpoint
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29 September 2017
DNA-PKcs activates the Chk2-Brca1 pathway during mitosis to ensure chromosomal stability
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
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29 September 2017
HIV integration and T cell death: additional commentary.
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29 September 2017
Mass spectrometry coupled experiments and protein structure modeling methods.
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29 September 2017
A new method for high-resolution imaging of Ku foci to decipher mechanisms of DNA double-strand break repair
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29 September 2017
HIV-1 causes CD4 cell death through DNA-dependent protein kinase during viral integration.
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29 September 2017
TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres
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29 September 2017
XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair
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PubMed Central
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29 September 2017
Detection and repair of ionizing radiation-induced DNA double strand breaks: new developments in nonhomologous end joining
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29 September 2017
A noncatalytic function of the ligation complex during nonhomologous end joining
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29 September 2017
PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase
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29 September 2017
Aurora-B mediated ATM serine 1403 phosphorylation is required for mitotic ATM activation and the spindle checkpoint
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29 September 2017
Phosphorylation of polynucleotide kinase/ phosphatase by DNA-dependent protein kinase and ataxia-telangiectasia mutated regulates its association with sites of DNA damage.
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PubMed Central
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29 September 2017
Destroying the ring: Freeing DNA from Ku with ubiquitin
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PubMed Central
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29 September 2017
Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
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PubMed Central
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29 September 2017
Choosing the right path: does DNA-PK help make the decision?
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29 September 2017
Involvement of DNA-dependent protein kinase in normal cell cycle progression through mitosis
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PubMed Central
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29 September 2017
Inhibition of homologous recombination by DNA-dependent protein kinase requires kinase activity, is titratable, and is modulated by autophosphorylation
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PubMed Central
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29 September 2017
XLF regulates filament architecture of the XRCC4·ligase IV complex
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29 September 2017
Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
A structural model for regulation of NHEJ by DNA-PKcs autophosphorylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Insulin signaling in fatty acid and fat synthesis: a transcriptional perspective
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
DNA damage signaling in response to double-strand breaks during mitosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
PR65, the HEAT-repeat scaffold of phosphatase PP2A, is an elastic connector that links force and catalysis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Telomeres: protecting chromosomes against genome instability
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Cell nonhomologous end joining capacity controls SAF-A phosphorylation by DNA-PK in response to DNA double-strand breaks inducers.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
DNA-PK: relaying the insulin signal to USF in lipogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
hnRNP-U is a specific DNA-dependent protein kinase substrate phosphorylated in response to DNA double-strand breaks.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Telomere dysfunction and DNA-PKcs deficiency: characterization and consequence
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
The Ku80 carboxy terminus stimulates joining and artemis-mediated processing of DNA ends
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Ku80 removal from DNA through double strand break-induced ubiquitylation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Cryo-EM structure of the DNA-dependent protein kinase catalytic subunit at subnanometer resolution reveals alpha helices and insight into DNA binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
trans Autophosphorylation at DNA-dependent protein kinase's two major autophosphorylation site clusters facilitates end processing but not end joining
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Autophosphorylation of DNA-dependent protein kinase regulates DNA end processing and may also alter double-strand break repair pathway choice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Cell cycle dependence of DNA-dependent protein kinase phosphorylation in response to DNA double strand breaks.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
DNA-PKcs is critical for telomere capping
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Utilization of oriented peptide libraries to identify substrate motifs selected by ATM.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Protein-DNA complexes containing DNA-dependent protein kinase in crude extracts from human and rodent cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Herpes simplex virus type 1 immediate-early protein vmw110 induces the proteasome-dependent degradation of the catalytic subunit of DNA-dependent protein kinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Attenuation of DNA-dependent protein kinase activity and its catalytic subunit by the herpes simplex virus type 1 transactivator ICP0.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Identification of the catalytic subunit of DNA dependent protein kinase as the product of the mouse scid gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Relationship of the ataxia-telangiectasia protein ATM to phosphoinositide 3-kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
DNA damage and the DNA-activated protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
When is a lipid kinase not a lipid kinase? When it is a protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Double-stranded DNA induces the phosphorylation of several proteins including the 90 000 mol. wt. heat-shock protein in animal cell extracts
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Analysis of the mechanism of interaction of simian Ku protein with DNA
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
The nuclear serine/threonine protein kinase DNA-PK
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
29 September 2017
CryoEM and image sorting for flexible protein/DNA complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
2 June 2018
DNA-PK and ATM phosphorylation sites in XLF/Cernunnos are not required for repair of DNA double strand breaks
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
2 June 2018
Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
2 June 2018
Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
2 June 2018
GC box binding induces phosphorylation of Sp1 by a DNA-dependent protein kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
2 June 2018
DNA damage: Dispersing Golgi.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
Golgi feels DNA's pain.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
DNA-PKcs associates with PLK1 and is involved in proper chromosome segregation and cytokinesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
γH2AX foci formation in the absence of DNA damage: mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
HIV: Integration triggers death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
Inactivation of DNA-dependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 Phosphorylation in response to DNA damage.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
Identification of DNA-PK in the arthropods. Evidence for the ancient ancestry of vertebrate non-homologous end-joining
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
DNA-PK phosphorylation sites in XRCC4 are not required for survival after radiation or for V(D)J recombination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
The ATRs, ATMs, and TORs are giant HEAT repeat proteins.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4502593
retrieved
27 November 2018
Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The DNA-dependent protein kinase is inactivated by autophosphorylation of the catalytic subunit
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Irradiation of parts of individual cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The human double-stranded DNA-activated protein kinase phosphorylates the 90-kDa heat-shock protein, hsp90 alpha at two NH2-terminal threonine residues
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Absence of a Ku-like DNA end binding activity in the xrs double-strand DNA repair-deficient mutant
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Threonine 68 phosphorylation by ataxia telangiectasia mutated is required for efficient activation of Chk2 in response to ionizing radiation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
DNA-stimulated protein phosphorylation in HeLa whole cell and nuclear extracts
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Ku entry into DNA inhibits inward DNA transactions in vitro
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Photocross-linking of an oriented DNA repair complex. Ku bound at a single DNA end
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Mechanism of interaction between Ku protein and DNA
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25550082
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.PBIOMOLBIO.2014.12.003
0 references
Fatcat ID
release_etsvw2nzy5g7zgcrqydtgkeltm
0 references
PMC publication ID
4502593
1 reference
stated in
PubMed
PubMed publication ID
25550082
1 reference
stated in
PubMed
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