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The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy
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title
The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy
(English)
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author name string
T. A. Waldmann
series ordinal
1
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language of work or name
English
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publication date
March 2015
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published in
Cancer Immunology Research
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PubMed
volume
3
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PubMed
issue
3
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PubMed
page(s)
219-27
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PubMed
cites work
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Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'
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Interleukin-15 biology and its therapeutic implications in cancer
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20 March 2017
Crystal Structure of the interleukin-15.interleukin-15 receptor alpha complex: insights into trans and cis presentation
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20 March 2017
Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans
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Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
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IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells
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Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor
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Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor
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20 March 2017
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
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20 March 2017
IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells
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20 March 2017
IL-15/IL-15Ralpha intracellular trafficking in human melanoma cells and signal transduction through the IL-15Ralpha
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Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors
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The 5' untranslated region, signal peptide, and the coding sequence of the carboxyl terminus of IL-15 participate in its multifaceted translational control
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The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID
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20 March 2017
Distinct pathways involving the FK506-binding proteins 12 and 12.6 underlie IL-2-versus IL-15-mediated proliferation of T cells
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20 March 2017
A function for interleukin 2 in Foxp3-expressing regulatory T cells
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Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice
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Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15
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Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
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7 April 2017
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
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Signaling in lymphocyte activation
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Redistribution, hyperproliferation, activation of natural killer cells and CD8 T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer
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Highly potent anti-CD20-RLI immunocytokine targeting established human B lymphoma in SCID mouse
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29 September 2017
The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
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29 September 2017
Molecular pathways: interleukin-15 signaling in health and in cancer
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Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rα cytokine compared to IL-15 monomer
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Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia
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29 September 2017
Augmented IL-15Rα expression by CD40 activation is critical in synergistic CD8 T cell-mediated antitumor activity of anti-CD40 antibody with IL-15 in TRAMP-C2 tumors in mice
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An antibody fusion protein for cancer immunotherapy mimicking IL-15 trans-presentation at the tumor site
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29 September 2017
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
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29 September 2017
The role of interleukin-2 during homeostasis and activation of the immune system
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29 September 2017
IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8+ T effector memory population in peripheral blood
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Increased serum soluble IL-15Rα levels in T-cell large granular lymphocyte leukemia
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A role for interleukin-2 trans-presentation in dendritic cell-mediated T cell activation in humans, as revealed by daclizumab therapy
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IL-15 and IL-2 increase Cetuximab-mediated cellular cytotoxicity against triple negative breast cancer cell lines expressing EGFR.
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Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model
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High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor alpha fusion protein, in metastatic melanoma and colorectal cancer
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29 September 2017
Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer
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29 September 2017
Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cis
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29 September 2017
IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation
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Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism
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Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action
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NK cells stimulated with IL-15 or CpG ODN enhance rituximab-dependent cellular cytotoxicity against B-cell lymphoma.
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Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo
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Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance
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29 September 2017
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29 September 2017
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29 September 2017
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29 September 2017
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29 September 2017
Overview of the trastuzumab (Herceptin) anti-HER2 monoclonal antibody clinical program in HER2-overexpressing metastatic breast cancer. Herceptin Multinational Investigator Study Group
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29 September 2017
Preassembly of interleukin 2 (IL-2) receptor subunits on resting Kit 225 K6 T cells and their modulation by IL-2, IL-7, and IL-15: a fluorescence resonance energy transfer study
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29 September 2017
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29 September 2017
Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
29 September 2017
An antibody-interleukin 2 fusion protein overcomes tumor heterogeneity by induction of a cellular immune response
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
29 September 2017
Antibody-interleukin 2 fusion proteins: a new approach to cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
29 September 2017
Fas and the art of lymphocyte maintenance
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
29 September 2017
Interleukin (IL) 15/IL-T production by the adult T-cell leukemia cell line HuT-102 is associated with a human T-cell lymphotrophic virus type I region /IL-15 fusion message that lacks many upstream AUGs that normally attenuates IL-15 mRNA translatio
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
29 September 2017
The IL-2/IL-2 receptor system: a current overview
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
29 September 2017
The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
29 September 2017
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
29 September 2017
The interleukin-2 receptor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
29 September 2017
Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
2 June 2018
Transregulation of memory CD8 T-cell proliferation by IL-15Rα+ bone marrow–derived cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
2 June 2018
Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
2 June 2018
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
2 June 2018
IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
27 November 2018
Combination treatment with IL-2 and anti-IL-2 mAbs reduces tumor metastasis via NK cell activation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
27 November 2018
Selective stimulation of T cell subsets with antibody-cytokine immune complexes.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
27 November 2018
Cutting edge: CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
27 November 2018
Failed adoptive immunotherapy with tumor-specific T cells: reversal with low-dose interleukin 15 but not low-dose interleukin 2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
27 November 2018
Targeted cytokines for cancer immunotherapy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
27 November 2018
Rapid regression of chemotherapy refractory lymphocyte predominant Hodgkin's disease after administration of rituximab (anti CD 20 mono- clonal antibody) and interleukin-2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
27 November 2018
Humanized Mik beta 1, a humanized antibody to the IL-2 receptor beta-chain that acts synergistically with humanized anti-TAC.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
27 November 2018
Development and proliferation of lymphocytes in mice deficient for both interleukins-2 and -4
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
27 November 2018
Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4351780
retrieved
27 November 2018
IL-15 cis presentation is required for optimal NK cell activation in lipopolysaccharide-mediated inflammatory conditions
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25736261
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25736261
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Administration of R24 monoclonal antibody and low-dose interleukin 2 for malignant melanoma
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25736261
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Fueling regulation: IL-2 keeps CD4+ Treg cells fit
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25736261
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Essential role of CD8+CD122+ regulatory T cells in the recovery from experimental autoimmune encephalomyelitis
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25736261
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Studies evaluating the antitumor activity and toxicity of interleukin-15, a new T cell growth factor: comparison with interleukin-2
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25736261
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
IL-15 Mediates Anti-tumor Effects after Cyclophosphamide Injection of Tumor-Bearing Mice and Enhances Adoptive Immunotherapy: The Potential Role of NK Cell Subpopulations
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25736261
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation. Daclizumab Triple Therapy Study Group
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25736261
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1158/2326-6066.CIR-15-0009
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3340703
OpenCitations bibliographic resource ID
3340703
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3340703
PMC publication ID
4351780
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3340703
PubMed publication ID
25736261
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3340703
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