(Q28118734)

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UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy

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scholarly article

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4 January 2017

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy (English)

2 references

PubMed publication ID

4 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

ubiquitin-proteasome system

0 references

ubiquitin C-terminal hydrolase L1

1 reference

GOA release 2020-03-11

regulation of macroautophagy

1 reference

GOA release 2020-03-11

1 reference

based on heuristic

inferred from title

0 references

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

author name string

Safia Costes

1

2 references

PubMed publication ID

4 January 2017

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Tatyana Gurlo

2

2 references

PubMed publication ID

4 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

Jacqueline F Rivera

3

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

publication date

1 June 2014

2 references

PubMed publication ID

4 January 2017

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

2 references

PubMed publication ID

4 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

10

2 references

PubMed publication ID

4 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

6

2 references

PubMed publication ID

4 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1004-1014

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

20 March 2017

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

20 March 2017

Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

20 March 2017

Atomic View of a Toxic Amyloid Small Oligomer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

20 March 2017

Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

20 March 2017

Stimulation of autophagy improves endoplasmic reticulum stress-induced diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

20 March 2017

The neuron-specific protein PGP 9.5 is a ubiquitin carboxyl-terminal hydrolase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

20 March 2017

Autophagy: process and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

7 April 2017

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

7 April 2017

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

7 April 2017

A role for ubiquitin in selective autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

7 April 2017

Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

7 April 2017

Recessive loss of function of the neuronal ubiquitin hydrolase UCHL1 leads to early-onset progressive neurodegeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

β-Cell failure in type 2 diabetes: a case of asking too much of too few?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin-proteasome system in pancreatic beta cell dysfunction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Ubiquitin C-terminal hydrolase L1 is required for pancreatic beta cell survival and function in lipotoxic conditions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Endoplasmic reticulum stress and pancreatic β-cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

INS-1 cells undergoing caspase-dependent apoptosis enhance the regenerative capacity of neighboring cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Evidence for proteotoxicity in beta cells in type 2 diabetes: toxic islet amyloid polypeptide oligomers form intracellularly in the secretory pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Beta-cell deterioration during diabetes: what's in the gun?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

p62 at the crossroads of autophagy, apoptosis, and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Prospective cohort study of type 2 diabetes and the risk of Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

CpG hypermethylation of the UCHL1 gene promoter is associated with pathogenesis and poor prognosis in renal cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Aberrant molecular properties shared by familial Parkinson's disease-associated mutant UCH-L1 and carbonyl-modified UCH-L1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Lysine 63-linked ubiquitination promotes the formation and autophagic clearance of protein inclusions associated with neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Induction of endoplasmic reticulum stress-induced beta-cell apoptosis and accumulation of polyubiquitinated proteins by human islet amyloid polypeptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Inhibitory effects of pesticides on proteasome activity: implication in Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

The relationship between diabetes mellitus and Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

29 September 2017

Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

2 June 2018

Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4091165

2 June 2018

Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28478

21 January 2018

UCHL1 is a Parkinson's disease susceptibility gene

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28478

21 January 2018

A dominant role for glucose in beta cell compensation of insulin resistance

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28478

21 January 2018

Biochemical and morphological detection of inclusion bodies in autophagy-deficient mice

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28478

21 January 2018

Autophagy-independent incorporation of GFP-LC3 into protein aggregates is dependent on its interaction with p62/SQSTM1.

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28478

21 January 2018

Type 2 diabetes and the risk of Parkinson's disease.

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28478

21 January 2018

Increased risk of type 2 diabetes in Alzheimer disease

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28478

21 January 2018

Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28478

21 January 2018

Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28478

21 January 2018

Consideration about negative controls for LC3 and expression vectors for four colored fluorescent protein-LC3 negative controls

1 reference

https://api.crossref.org/works/10.4161%2FAUTO.28478

21 January 2018

Evidence for a Role of the Ubiquitin-Proteasome Pathway in Pancreatic Islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/24879150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Insights into links between familial and sporadic Parkinson's disease: physical relationship between UCH-L1 variants and chaperone-mediated autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24879150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of cystic fibrosis transmembrane conductance regulator transcriptional repression during the unfolded protein response

1 reference

https://pubmed.ncbi.nlm.nih.gov/24879150

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/AUTO.28478

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

PubMed publication ID

2 references

PubMed publication ID

4 January 2017

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24879150%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

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