(Q28237347)

1

0 references

Min Xu

2

0 references

Qian Huang

3

0 references

Craig A Coburn

4

0 references

Kristen L G Jones

5

0 references

Marc Ferrer

6

0 references

Paul D Zuck

7

0 references

Eric A Price

9

0 references

Guoxin Wu

10

0 references

Abigail L Wolfe

11

0 references

Janet E Lineberger

12

0 references

Mohinder Sardana

13

0 references

Katherine Tugusheva

14

0 references

Beth L Pietrak

15

0 references

Ming-Chih Crouthamel

16

0 references

Ming-Tain Lai

17

0 references

Elizabeth Chen Dodson

18

0 references

Renzo Bazzo

19

0 references

Xiao-Ping Shi

20

0 references

Adam J Simon

21

0 references

Yueming Li

22

0 references

Daria J Hazuda

Journal of Biological Chemistry

23

0 references

language of work or name

English

0 references

publication date

6 May 2005

0 references

published in

0 references

volume

280

0 references

issue

18

0 references

page(s)

17792-7

0 references

cites work

Alzheimer Disease in the US Population

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Alzheimer's disease: the amyloid cascade hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Synaptic targeting by Alzheimer's-related amyloid beta oligomers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Inhibition of Receptor-mediated Endocytosis Demonstrates Generation of Amyloid β-Protein at the Cell Surface

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Amyloid-beta oligomers: their production, toxicity and therapeutic inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Therapeutic strategies for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Peptide inhibitors of beta amyloid aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Approaches to discovery and characterization of inhibitors of amyloid beta-peptide polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Design and synthesis of statine-containing BACE inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Design and Synthesis of Statine-Based Cell-Permeable Peptidomimetic Inhibitors of Human β-Secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Design of substrate-based inhibitors of human beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Structure-based design: potent inhibitors of human brain memapsin 2 (beta-secretase).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Design and synthesis of hydroxyethylene-based peptidomimetic inhibitors of human beta-secretase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

P3 cap modified Phe*-Ala series BACE inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Rational design and synthesis of selective BACE-1 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Identification of a small molecule nonpeptide active site beta-secretase inhibitor that displays a nontraditional binding mode for aspartyl proteases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Catalytic site-directed gamma-secretase complex inhibitors do not discriminate pharmacologically between Notch S3 and beta-APP cleavages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Design and synthesis of highly potent benzodiazepine gamma-secretase inhibitors: preparation of (2S,3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by us

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

A common enzyme connects notch signaling and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Adipsin, a biomarker of gastrointestinal toxicity mediated by a functional gamma-secretase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

gamma-Secretase: characterization and implication for Alzheimer disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Selected non-steroidal anti-inflammatory drugs and their derivatives target gamma-secretase at a novel site. Evidence for an allosteric mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Benzofuran derivatives as Abeta-aggregate-specific imaging agents for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß 42 by Inhibiting Rho

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200

Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414331200