(Q28251868)

1

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N J Bradshaw

2

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D C Soares

3

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D J Porteous

4

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J K Millar

Association within a family of a balanced autosomal translocation with major mental illness

5

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language of work or name

English

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publication date

January 2008

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published in

Molecular Psychiatry

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volume

13

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issue

1

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page(s)

36-64

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cites work

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Schizophrenia and affective disorders--cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family.

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Disruption of two novel genes by a translocation co-segregating with schizophrenia

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Genome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Chromosome 1 loci in Finnish schizophrenia families

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

A frameshift mutation in Disrupted in Schizophrenia 1 in an American family with schizophrenia and schizoaffective disorder

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Evolutionary constraints on the Disrupted in Schizophrenia locus

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Trax (translin-associated factor X), a primarily cytoplasmic protein, inhibits the binding of TB-RBP (translin) to RNA

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Disrupted in Schizophrenia 1 (DISC1) is a multicompartmentalized protein that predominantly localizes to mitochondria

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

A schizophrenia-associated mutation of DISC1 perturbs cerebral cortex development

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

The PSIPRED protein structure prediction server

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

DISC1 localizes to the centrosome by binding to kendrin

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

DISC1 regulates neurotrophin-induced axon elongation via interaction with Grb2

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

PC12 cell model of inducible expression of mutant DISC1: new evidence for a dominant-negative mechanism of abnormal neuronal differentiation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Yeast two-hybrid screens implicate DISC1 in brain development and function

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Rolipram: a specific phosphodiesterase 4 inhibitor with potential antipsychotic activity.

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Isolation of a Miller-Dieker lissencephaly gene containing G protein beta-subunit-like repeats

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Point mutations and an intragenic deletion in LIS1, the lissencephaly causative gene in isolated lissencephaly sequence and Miller-Dieker syndrome

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Graded reduction of Pafah1b1 (Lis1) activity results in neuronal migration defects and early embryonic lethality

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

A LIS1/NUDEL/cytoplasmic dynein heavy chain complex in the developing and adult nervous system

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Mitotic spindle regulation by Nde1 controls cerebral cortical size

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Complete loss of Ndel1 results in neuronal migration defects and early embryonic lethality

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Recruitment of katanin p60 by phosphorylated NDEL1, an LIS1 interacting protein, is essential for mitotic cell division and neuronal migration

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Reduction of microtubule catastrophe events by LIS1, platelet-activating factor acetylhydrolase subunit.

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Human Nudel and NudE as regulators of cytoplasmic dynein in poleward protein transport along the mitotic spindle

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

NudE-L, a novel Lis1-interacting protein, belongs to a family of vertebrate coiled-coil proteins

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Regulation of cytoplasmic dynein behaviour and microtubule organization by mammalian Lis1

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Miller-Dieker lissencephaly gene encodes a subunit of brain platelet-activating factor acetylhydrolase [corrected]

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Inhibition of NUDEL (nuclear distribution element-like)-oligopeptidase activity by disrupted-in-schizophrenia 1

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

14-3-3zeta is an effector of tau protein phosphorylation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

14-3-3epsilon is important for neuronal migration by binding to NUDEL: a molecular explanation for Miller-Dieker syndrome

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

SH3 ligands in the dopamine D3 receptor

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

SH3 domain-dependent association of huntingtin with epidermal growth factor receptor signaling complexes

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

The unique N-terminal domain of the cAMP phosphodiesterase PDE4D4 allows for interaction with specific SH3 domains

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Neuregulin 1-erbB signaling and the molecular/cellular basis of schizophrenia

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

The Caenorhabditis elegans gene unc-76 and its human homologs define a new gene family involved in axonal outgrowth and fasciculation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

The GABA(B) receptor subunits R1 and R2 interact differentially with the activation transcription factor ATF4 in mouse brain during the postnatal development

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

The metabotropic GABAB receptor directly interacts with the activating transcription factor 4

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

21 April 2017

All roads lead to ATF4

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Brain‐specific expression of human microtubule‐associated protein 1A (MAP1A) gene and its assignment to human chromosome 15

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Human microtubule-associated protein 1a (MAP1A) gene: genomic organization, cDNA sequence, and developmental- and tissue-specific expression

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Microtubule associated protein MAP1A is an actin-binding and crosslinking protein

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Centrosomal proteins Nde1 and Su48 form a complex regulated by phosphorylation

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Do natural antisense transcripts make sense in eukaryotes?

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Huntingtin and its role in neuronal degeneration

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain

21 April 2017

1 reference

https://api.crossref.org/works/10.1038/SJ.MP.4002106

A "silent" polymorphism in the MDR1 gene changes substrate specificity

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Identification of genes from a schizophrenia-linked translocation breakpoint region

21 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Genomic structure and localisation within a linkage hotspot of Disrupted In Schizophrenia 1, a gene disrupted by a translocation segregating with schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

A genomewide screen for schizophrenia genes in an isolated Finnish subpopulation, suggesting multiple susceptibility loci

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Replication of 1q42 linkage in Finnish schizophrenia pedigrees

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Genomewide Linkage Scan in Schizoaffective Disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Linkage of schizophrenia with chromosome 1q loci in Taiwanese families.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Identification of polymorphisms within Disrupted in Schizophrenia 1 and Disrupted in Schizophrenia 2, and an investigation of their association with schizophrenia and bipolar affective disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

A haplotype within the DISC1 gene is associated with visual memory functions in families with a high density of schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Positive association of the Disrupted-in-Schizophrenia-1 gene (DISC1) with schizophrenia in the Chinese Han population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Association between the TRAX/DISC locus and both bipolar disorder and schizophrenia in the Scottish population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Case-control association study of Disrupted-in-Schizophrenia-1 (DISC1) gene and schizophrenia in the Chinese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Association study of polymorphisms in the 5' upstream region of human DISC1 gene with schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Association study of the DISC1/TRAX locus with schizophrenia in a Japanese population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Evidence that a DISC1 frame-shift deletion associated with psychosis in a single family may not be a pathogenic mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

DISC1 and neurocognitive function in schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Association of DISC1/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Genetic linkage and association between chromosome 1q and working memory function in schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Association between genotype at an exonic SNP in DISC1 and normal cognitive aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

A single nucleotide polymorphism fine mapping study of chromosome 1q42.1 reveals the vulnerability genes for schizophrenia, GNPAT and DISC1: Association with impairment of sustained attention.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Search for cognitive trait components of schizophrenia reveals a locus for verbal learning and memory on 4q and for visual working memory on 2q.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Modeling madness in mice: one piece at a time

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

A review of Disrupted-In-Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for gene-targeting studies of brain function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Multi-phenotype behavioral characterization of inbred strains derived from wild stocks of Mus musculus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Molecular characterization of ENU mouse mutagenesis and archives

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Behavioral phenotypes of Disc1 missense mutations in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Dominant-negative DISC1 transgenic mice display schizophrenia-associated phenotypes detected by measures translatable to humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Primate disrupted-in-schizophrenia-1 (DISC1): high divergence of a gene for major mental illnesses in recent evolutionary history.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Cloning and characterization of Disc1, the mouse ortholog of DISC1 (Disrupted-in-Schizophrenia 1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Expression of DISC1 binding partners is reduced in schizophrenia and associated with DISC1 SNPs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Chromosomal location and genomic structure of the human translin-associated factor X gene (TRAX; TSNAX) revealed by intergenic splicing to DISC1, a gene disrupted by a translocation segregating with schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

BC1 RNA protein particles in mouse brain contain two y-,h-element-binding proteins, translin and a 37 kDa protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

A functional link between Disrupted-In-Schizophrenia 1 and the eukaryotic translation initiation factor 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

A form of DISC1 enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Disrupted in schizophrenia 1 (DISC1): subcellular targeting and induction of ring mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

PROMALS: towards accurate multiple sequence alignments of distantly related proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Expression of disrupted in schizophrenia 1 (DISC1) protein in the adult and developing mouse brain indicates its role in neurodevelopment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

DISC1 (Disrupted in Schizophrenia-1) is expressed in limbic regions of the primate brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

The hippocampus in schizophrenia: a review of the neuropathological evidence and its pathophysiological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Memory and socioemotional behavior in monkeys after hippocampal damage incurred in infancy or in adulthood.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Neonatal lesions of the ventral hippocampus in rats lead to prefrontal cognitive deficits at two maturational stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Expression of Disrupted-In-Schizophrenia-1, a schizophrenia-associated gene, is prominent in the mouse hippocampus throughout brain development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Subcellular targeting of DISC1 is dependent on a domain independent from the Nudel binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

DISC1 immunoreactivity at the light and ultrastructural level in the human neocortex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Differential expression of disrupted-in-schizophrenia (DISC1) in bipolar disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Effects of the novel PDE4 inhibitors MEM1018 and MEM1091 on memory in the radial-arm maze and inhibitory avoidance tests in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Rolipram reverses scopolamine-induced and time-dependent memory deficits in object recognition by different mechanisms of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

The PDE4 inhibitor rolipram reverses object memory impairment induced by acute tryptophan depletion in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Effects of rolipram on scopolamine-induced impairment of working and reference memory in the radial-arm maze tests in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Regulation of the phosphodiesterase PDE4B3-isotype during long-term potentiation in the area dentata in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Changes in NMDA receptor-induced cyclic nucleotide synthesis regulate the age-dependent increase in PDE4A expression in primary cortical cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Activity of cyclic AMP phosphodiesterases and adenylyl cyclase in peripheral nerve after crush and permanent transection injuries

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

The PDE4B gene confers sex-specific protection against schizophrenia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Signaling networks in the pathophysiology and treatment of mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Signaling pathways regulating gene expression, neuroplasticity, and neurotrophic mechanisms in the action of antidepressants: a critical overview.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Pathophysiology of depression: the concept of synaptic plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Synaptic plasticity and mood disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Antipsychotic profile of rolipram: efficacy in rats and reduced sensitivity in mice deficient in the phosphodiesterase-4B (PDE4B) enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Identification, characterization and regional distribution in brain of RPDE-6 (RNPDE4A5), a novel splice variant of the PDE4A cyclic AMP phosphodiesterase family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Regulation of cAMP-specific phosphodiesterases type 4B and 4D (PDE4) splice variants by cAMP signaling in primary cortical neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Regulation of cAMP phosphodiesterase mRNAs expression in rat brain by acute and chronic fluoxetine treatment. An in situ hybridization study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Regulation of phosphodiesterase-4 (PDE4) expression in mouse brain by repeated antidepressant treatment: comparison with rolipram

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Identification of lithium-regulated genes in cultured lymphoblasts of lithium responsive subjects with bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Chronic nicotine doses down-regulate PDE4 isoforms that are targets of antidepressants in adolescent female rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Sub-family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP-specific phosphodiesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Lissencephaly and the molecular basis of neuronal migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Granule cell dispersion and aberrant neurogenesis in the adult hippocampus of an LIS1 mutant mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

NudF, a nuclear migration gene in Aspergillus nidulans, is similar to the human LIS-1 gene required for neuronal migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

The "8-kD" cytoplasmic dynein light chain is required for nuclear migration and for dynein heavy chain localization in Aspergillus nidulans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Cytoplasmic dynein is involved in nuclear migration in Aspergillus nidulans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Isolation of a new set of Aspergillus nidulans mutants defective in nuclear migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

The centrosome in human genetic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Nucleokinesis in neuronal migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Par6alpha signaling controls glial-guided neuronal migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Interaction between LIS1 and doublecortin, two lissencephaly gene products

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Drosophila Lis1 is required for neuroblast proliferation, dendritic elaboration and axonal transport.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Live imaging of Drosophila brain neuroblasts reveals a role for Lis1/dynactin in spindle assembly and mitotic checkpoint control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Expression of endo-oligopeptidase A in the rat central nervous system: a non-radioactive in situ hybridization study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Degradation of neurotensin by rabbit brain endo-oligopeptidase A and endo-oligopeptidase B (proline-endopeptidase)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Preparation, assay, and partial characterization of a neutral endopeptidase from rabbit brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Variations in genes regulating neuronal migration predict reduced prefrontal cognition in schizophrenia and bipolar subjects from mediterranean Spain: A preliminary study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Families with the risk allele of DISC1 reveal a link between schizophrenia and another component of the same molecular pathway, NDE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

14-3-3 connects glycogen synthase kinase-3 beta to tau within a brain microtubule-associated tau phosphorylation complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Identification and characterization of the gene causing type 1 spinocerebellar ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Unlocking the code of 14-3-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

14-3-3 protein eta chain gene (YWHAH) polymorphism and its genetic association with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Identification of candidate genes for psychosis in rat models, and possible association between schizophrenia and the 14-3-3eta gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

An association study between polymorphisms in three genes of 14-3-3 (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein) family and paranoid schizophrenia in northern Chinese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Altered expression of 14-3-3 genes in the prefrontal cortex of subjects with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Proteomic analysis of rat cortical neurons after fluoxetine treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

SH3 binding domains in the dopamine D4 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Apoptotic cell death and amyloid precursor protein signaling in neuroblastoma SH-SY5Y cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Expression of fasciculation and elongation protein zeta-1 (FEZ1) in the developing rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Fasciculation and elongation protein zeta-1 (FEZ1) participates in the polarization of hippocampal neuron by controlling the mitochondrial motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Two binding partners cooperate to activate the molecular motor Kinesin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Failure to confirm the association between the FEZ1 gene and schizophrenia in a Japanese population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

The FEZ1 gene shows no association to schizophrenia in Caucasian or African American populations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

GABA(B) receptors couple directly to the transcription factor ATF4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

cAMP response element-binding protein, activating transcription factor-4, and upstream stimulatory factor differentially control hippocampal GABABR1a and GABABR1b subunit gene expression through alternative promoters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Memory suppressor genes: inhibitory constraints on the storage of long-term memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Inducible enhancement of memory storage and synaptic plasticity in transgenic mice expressing an inhibitor of ATF4 (CREB-2) and C/EBP proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

ATF5 regulates the proliferation and differentiation of oligodendrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Regulation of asparagine synthetase gene transcription by the basic region leucine zipper transcription factors ATF5 and CHOP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Amino acid limitation induces expression of ATF5 mRNA at the post-transcriptional level

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Association analysis of ATF4 and ATF5, genes for interacting-proteins of DISC1, in bipolar disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

The MAP1 family of microtubule-associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

The guanylate kinase domain of the MAGUK PSD-95 binds dynamically to a conserved motif in MAP1a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Infantile Autism and Associated Autosomal Chromosome Abnormalities: A Register-based Study and a Literature Survey

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Chromosomal fragile site expression in Turkish psychiatric patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

The evolution of controlled multitasked gene networks: the role of introns and other noncoding RNAs in the development of complex organisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Overlapping transcripts, double-stranded RNA and antisense regulation: a genomic perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Non-coding RNAs: new players in eukaryotic biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23-q24, and suggests the presence of additional loci on 1p and 1q

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

Clinical phenotypes associated with DISC1, a candidate gene for schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Direct microdissection and microcloning of a translocation breakpoint region, t(1;11)(q42.2;q21), associated with schizophrenia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

A Contiguous Clone Map over 3 Mb on the Long Arm of Chromosome 11 across a Balanced Translocation Associated with Schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Novel transcribed sequences neighbouring a translocation breakpoint associated with schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

A long-range restriction map across 3 Mb of the chromosome 11 breakpoint region of a translocation linked to schizophrenia: localization of the breakpoint and the search for neighbouring genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Association of DISC1 with autism and Asperger syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Neurobiology of schizophrenia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Inducible expression of mutant human DISC1 in mice is associated with brain and behavioral abnormalities reminiscent of schizophrenia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

BLAST 2 Sequences, a new tool for comparing protein and nucleotide sequences

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

BLAT—The BLAST-Like Alignment Tool

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

The stanley foundation brain collection and neuropathology consortium

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Physiology and biochemistry of Drosophila learning mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Reduced growth cone motility in cultured neurons from Drosophila memory mutants with a defective cAMP cascade.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Outward currents in Drosophila larval neurons: dunce lacks a maintained outward current component downregulated by cAMP.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Alterations in frequency coding and activity dependence of excitability in cultured neurons of Drosophila memory mutants.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

cAMP-dependent plasticity at excitatory cholinergic synapses in Drosophila neurons: alterations in the memory mutant dunce.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Inhibition of cyclic AMP phosphodiesterase (PDE4) reverses memory deficits associated with NMDA receptor antagonism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

The induction of cyclic nucleotide phosphodiesterase 4 gene (PDE4D) impairs memory in a water maze task

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Therapeutic potential of phosphodiesterase type 4 inhibition in chronic autoimmune demyelinating disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Characterization of the rolipram-sensitive, cyclic AMP-specific phosphodiesterases: identification and differential expression of immunologically distinct forms in the rat brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Differential changes in the expression of cyclic nucleotide phosphodiesterase isoforms in rat brains by chronic treatment with electroconvulsive shock

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Multiple dose-dependent effects of Lis1 on cerebral cortical development

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Ndel1 operates in a common pathway with LIS1 and cytoplasmic dynein to regulate cortical neuronal positioning

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Lissencephaly gene (LIS1) expression in the CNS suggests a role in neuronal migration

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Neurofibrillary tangles of Alzheimer's disease brains contain 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Signal transduction through tyrosine-phosphorylated carboxy-terminal fragments of APP via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Regulated expression of ATF5 is required for the progression of neural progenitor cells to neurons

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Infantile autism and associated autosomal chromosome abnormalities: a register-based study and a literature survey

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

Evidence for a putative bipolar disorder locus on 2p13-16 and other potential loci on 4q31, 7q34, 8q13, 9q31, 10q21-24, 13q32, 14q21 and 17q11-12

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

A genome-wide linkage search for bipolar disorder susceptibility loci in a large and complex pedigree from the eastern part of Cuba

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

The neuregulin-I/ErbB signaling system in development and disease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.MP.4002106

7 January 2021