(Q40168518)

18 September 2017

title

Amyloid precursor protein and Presenilin1 interact with the adaptor GRB2 and modulate ERK 1,2 signaling (English)

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18 September 2017

12

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18 September 2017

Maria Cristina Gagliani

Maria Cristina Gagliani

6

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Raffaella Magrassi

Raffaella Magrassi

5

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Emanuela Repetto

Emanuela Repetto

3

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Claudio Russo

Claudio Russo

13

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Tommaso Russo

Tommaso Russo

11

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Carlo Tacchetti

Carlo Tacchetti

10

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Tullio Florio

Tullio Florio

8

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author name string

Mario Nizzari

1

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18 September 2017

Valentina Venezia

2

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18 September 2017

Valentina Caorsi

4

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18 September 2017

Pia Carlo

7

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18 September 2017

Gennaro Schettini

9

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18 September 2017

language of work or name

English

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publication date

21 February 2007

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Journal of Biological Chemistry

18 September 2017

published in

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18 September 2017

volume

282

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18 September 2017

issue

18

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18 September 2017

page(s)

13833-13844

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Twenty years of the Alzheimer's disease amyloid hypothesis: a genetic perspective

18 September 2017

cites work

1 reference

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21 January 2018

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Alzheimer disease therapy: can the amyloid cascade be halted?

21 January 2018

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The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus

21 January 2018

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A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

21 January 2018

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Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

21 January 2018

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Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610146200

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide

21 January 2018

1 reference

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

21 January 2018

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Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610146200

Involvement of presenilins in cell-survival signalling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilin 1: more than just gamma-secretase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Protein phosphorylation and APP metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Signal transduction through tyrosine-phosphorylated C-terminal fragments of amyloid precursor protein via an enhanced interaction with Shc/Grb2 adaptor proteins in reactive astrocytes of Alzheimer's disease brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Interaction of Grb2 via its Src homology 3 domains with synaptic proteins including synapsin I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Grb2 dominantly associates with dynamin II in human hepatocellular carcinoma HepG2 cells

21 January 2018

1 reference

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Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle movement depends on N-WASP and involves Nck, WIP, and Grb2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Centrosome control of the cell cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The beta-amyloid precursor protein APP is tyrosine-phosphorylated in cells expressing a constitutively active form of the Abl protoncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

BACE1 Suppression by RNA Interference in Primary Cortical Neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Alsin is partially associated with centrosome in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Recruitment of the gamma-tubulin ring complex to Drosophila salt-stripped centrosome scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

γ-Tubulin is a highly conserved component of the centrosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Imaging protein-protein interactions using fluorescence resonance energy transfer microscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Subcellular localization of presenilins during mouse preimplantation development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Phosphorylation of amyloid precursor carboxy-terminal fragments enhances their processing by a gamma-secretase-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Heterogeneity of water-soluble amyloid beta-peptide in Alzheimer's disease and Down's syndrome brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Opposite roles of apolipoprotein E in normal brains and in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

MEK, ERK, and p90RSK are present on mitotic tubulin in Swiss 3T3 cells: a role for the MAP kinase pathway in regulating mitotic exit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Mitotic mechanisms in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Ligand-dependent G protein coupling function of amyloid transmembrane precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Platelet-derived growth factor induces the beta-gamma-secretase-mediated cleavage of Alzheimer's amyloid precursor protein through a Src-Rac-dependent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

A scaffold protein JIP-1b enhances amyloid precursor protein phosphorylation by JNK and its association with kinesin light chain 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Apoptotic cell death influences the signaling activity of the amyloid precursor protein through ShcA and Grb2 adaptor proteins in neuroblastoma SH-SY5Y cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The roles of signaling by the p42/p44 mitogen-activated protein (MAP) kinase pathway; a potential route to radio- and chemo-sensitization of tumor cells resulting in the induction of apoptosis and loss of clonogenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Centrosome amplification, chromosome instability and cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Dual control of caveolar membrane traffic by microtubules and the actin cytoskeleton

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Rab11 regulates recycling through the pericentriolar recycling endosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Notch oncoproteins depend on gamma-secretase/presenilin activity for processing and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610146200

21 January 2018

Identifiers

DOI

10.1074/JBC.M610146200

1 reference

18 September 2017

1 reference