(Q53280053)

12 May 2018

title

Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription. (English)

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12 May 2018

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Spiros Efthimiopoulos

5

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12 May 2018

author name string

Loukia Parisiadou

1

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12 May 2018

Angeliki Fassa

2

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12 May 2018

Angeliki Fotinopoulou

3

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12 May 2018

Ioanna Bethani

4

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12 May 2018

publication date

1 January 2004

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12 May 2018

Neurodegenerative Diseases

published in

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12 May 2018

volume

1

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12 May 2018

page(s)

184-191

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12 May 2018

issue

4-5

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12 May 2018

The Alzheimer family of diseases: many etiologies, one pathogenesis?

cites work

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Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production

21 January 2018

1 reference

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

21 January 2018

1 reference

Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease

21 January 2018

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Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells

21 January 2018

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

21 January 2018

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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Presenilin Proteins Undergo Heterogeneous Endoproteolysis between Thr291and Ala299and Occur as Stable N- and C-Terminal Fragments in Normal and Alzheimer Brain Tissue

21 January 2018

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The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

21 January 2018

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

21 January 2018

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

21 January 2018

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Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

21 January 2018

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

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APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

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aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

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γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2

21 January 2018

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The role of presenilin cofactors in the gamma-secretase complex

21 January 2018

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Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor.

21 January 2018

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Reconstitution of gamma-secretase activity

21 January 2018

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Amyloid beta-peptide is produced by cultured cells during normal metabolism

21 January 2018

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Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

21 January 2018

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

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A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

21 January 2018

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Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts

21 January 2018

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Expression and analysis of presenilin 1 in a human neuronal system: localization in cell bodies and dendrites

21 January 2018

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Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

21 January 2018

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Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex

21 January 2018

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A novel role for p120 catenin in E-cadherin function

21 January 2018

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A core function for p120-catenin in cadherin turnover

21 January 2018

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Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cells

21 January 2018

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Presenilin 1 is involved in maturation and trafficking of N‐cadherin to the plasma membrane

21 January 2018

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Effects of PS1 deficiency on membrane protein trafficking in neurons.

21 January 2018

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N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane

21 January 2018

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Biogenesis of N-cadherin-dependent cell-cell contacts in living fibroblasts is a microtubule-dependent kinesin-driven mechanism

21 January 2018

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Cleavage and shedding of E-cadherin after induction of apoptosis

21 January 2018

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Truncation of the beta-catenin binding domain of E-cadherin precedes epithelial apoptosis during prostate and mammary involution

21 January 2018

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Functional interaction of beta-catenin with the transcription factor LEF-1

21 January 2018

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Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling

21 January 2018

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Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

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Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4.

21 January 2018

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Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

21 January 2018

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A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

21 January 2018

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Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain

21 January 2018

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Function and regulation of CREB family transcription factors in the nervous system

21 January 2018

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A RIP tide in neuronal signal transduction

21 January 2018

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Involvement of amyloid as a central step in the development of Alzheimer's disease

21 January 2018

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Alzheimer's disease: a re-examination of the amyloid hypothesis

21 January 2018

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An Alzheimer's disease hypothesis based on transcriptional dysregulation

21 January 2018

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Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

21 January 2018

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Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein

21 January 2018

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Neurobiology: double trouble for neurons

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000080984

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12 May 2018

PubMed ID

16908988

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12 May 2018