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Effects of histone deacetylase inhibitors on HIF-1
scientific article
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instance of
scholarly article
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review article
1 reference
stated in
Europe PubMed Central
title
Effects of histone deacetylase inhibitors on HIF-1
(English)
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main subject
cell biology
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author name string
Dongming Liang
series ordinal
1
0 references
Xianguo Kong
series ordinal
2
0 references
Nianli Sang
series ordinal
3
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language of work or name
English
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publication date
1 November 2006
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published in
Cell Cycle
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volume
5
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issue
21
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page(s)
2430-5
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cites work
Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha
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Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1.
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Purified recombinant hARD1 does not catalyse acetylation of Lys532 of HIF-1alpha fragments in vitro
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Interaction between HIF-1 alpha (ODD) and hARD1 does not induce acetylation and destabilization of HIF-1 alpha
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PubMed Central
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Arrest-defective-1 protein, an acetyltransferase, does not alter stability of hypoxia-inducible factor (HIF)-1alpha and is not induced by hypoxia or HIF
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HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor
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Clinical development of histone deacetylase inhibitors as anticancer agents
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Analysis of ARD1 function in hypoxia response using retroviral RNA interference
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A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73
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Hydroxylation of HIF-1: oxygen sensing at the molecular level
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Histone deacetylase 7 associates with hypoxia-inducible factor 1alpha and increases transcriptional activity
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Hypoxia inducible factor-1alpha as a cancer drug target
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20 March 2017
Targeting HIF-1 for cancer therapy
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20 March 2017
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
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20 March 2017
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
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HDAC6 is a microtubule-associated deacetylase
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Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha
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Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response
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20 March 2017
Carboxyl-terminal transactivation activity of hypoxia-inducible factor 1 alpha is governed by a von Hippel-Lindau protein-independent, hydroxylation-regulated association with p300/CBP.
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20 March 2017
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
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20 March 2017
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
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HIF-1alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
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20 March 2017
Binding and regulation of HIF-1alpha by a subunit of the proteasome complex, PSMA7
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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
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20 March 2017
NuRD and SIN3 histone deacetylase complexes in development
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20 March 2017
Loss of PTEN facilitates HIF-1-mediated gene expression
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PubMed Central
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20 March 2017
Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha
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20 March 2017
Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505804
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20 March 2017
ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505804
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20 March 2017
HDAC-6 interacts with and deacetylates tubulin and microtubules in vivo
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20 March 2017
Requirement for p53 and p21 to sustain G2 arrest after DNA damage
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7 April 2017
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
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7 April 2017
Molecular chaperones and protein quality control
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7 April 2017
Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
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PubMed Central
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7 April 2017
Proteasomal inhibition attenuates transcriptional activity of hypoxia-inducible factor 1 (HIF-1) via specific effect on the HIF-1alpha C-terminal activation domain
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PubMed Central
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29 September 2017
Histone deacetylase inhibitors induce VHL and ubiquitin-independent proteasomal degradation of hypoxia-inducible factor 1alpha
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4505804
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29 September 2017
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.
1 reference
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PubMed Central
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29 September 2017
Both microtubule-stabilizing and microtubule-destabilizing drugs inhibit hypoxia-inducible factor-1alpha accumulation and activity by disrupting microtubule function.
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29 September 2017
The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing
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29 September 2017
Depletion of mutant p53 and cytotoxicity of histone deacetylase inhibitors
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29 September 2017
Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?
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29 September 2017
Accumulation of hypoxia-inducible factor-1alpha is limited by transcription-dependent depletion.
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29 September 2017
Class II histone deacetylases: from sequence to function, regulation, and clinical implication
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29 September 2017
The histone deacetylase inhibitor NVP-LAQ824 inhibits angiogenesis and has a greater antitumor effect in combination with the vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584.
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29 September 2017
Interaction of the PAS B domain with HSP90 accelerates hypoxia-inducible factor-1alpha stabilization.
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29 September 2017
Deacetylase recruitment by the C/H3 domain of the acetyltransferase p300.
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Hypoxia inducible factor as a cancer drug target
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29 September 2017
HIF-1 as a target for drug development
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29 September 2017
Histone deacetylase inhibitors in cancer therapy: is transcription the primary target?
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29 September 2017
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29 September 2017
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29 September 2017
MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300
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Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes
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27 November 2018
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
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Identifiers
DOI
10.4161/CC.5.21.3409
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4608055
OpenCitations bibliographic resource ID
4608055
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4608055
PMC publication ID
4505804
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4608055
PubMed publication ID
17102633
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4608055
ResearchGate publication ID
6694299
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