(Q28296317)

1

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Y Li

2

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H Zhang

3

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F Liu

4

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Z Cheng

5

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D Wang

6

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G Wang

7

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H Xu

8

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Y Zhao

9

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L Cao

10

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F Li

TGF-beta signal transduction

11

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language of work or name

English

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publication date

26 June 2014

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published in

Oncogene

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volume

33

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page(s)

3473-84

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issue

26

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cites work

1 reference

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20 April 2017

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PAK as a therapeutic target in gastric cancer

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p21-activated kinases in cancer

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Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma

20 April 2017

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Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

20 April 2017

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PAK4: a pluripotent kinase that regulates prostate cancer cell adhesion

20 April 2017

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Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element

20 April 2017

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Cloning and characterization of mouse UBPy, a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1

20 April 2017

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

20 April 2017

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3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins

20 April 2017

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Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF

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ELAC2, a putative prostate cancer susceptibility gene product, potentiates TGF-beta/Smad-induced growth arrest of prostate cells

20 April 2017

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Nucleo-cytoplasmic shuttling of PAK4 modulates β-catenin intracellular translocation and signaling

20 April 2017

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LCH-7749944, a novel and potent p21-activated kinase 4 inhibitor, suppresses proliferation and invasion in human gastric cancer cells

20 April 2017

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Downregulation of p21-activated kinase-1 inhibits the growth of gastric cancer cells involving cyclin B1

20 April 2017

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Specificity and versatility in tgf-beta signaling through Smads

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How cells read TGF-beta signals

20 April 2017

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Transcriptional control by the TGF-beta/Smad signaling system

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Dysregulation of cellular signaling in gastric cancer

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Transforming growth factor beta: tumor suppressor or promoter? Are host immune cells the answer?

21 January 2018

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Regulation of TGF-beta signalling by protein phosphatases

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Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment.

21 January 2018

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TGF-β signalling and its role in cancer progression and metastasis

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Concordant repression and aberrant methylation of transforming growth factor-beta signaling pathway genes occurs early in gastric cardia adenocarcinoma

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Systematic analysis of the TGF-beta-Smad signaling pathway in gastrointestinal cancer cells

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No mutations of the Smad2 gene in human sporadic gastric carcinomas

21 January 2018

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Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer.

21 January 2018

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Targeting group II PAKs in cancer and metastasis

21 January 2018

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PAK4-6 in cancer and neuronal development

21 January 2018

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Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer

21 January 2018

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Requirement for PAK4 in the anchorage-independent growth of human cancer cell lines

21 January 2018

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p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients

21 January 2018

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DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK1.

21 January 2018

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PAK4 is activated via PI3K in HGF-stimulated epithelial cells

21 January 2018

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A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest

21 January 2018

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Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

21 January 2018

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Effects of activin and TGFβ on p21 in colon cancer

21 January 2018

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Death receptor-induced activation of initiator caspase 8 is antagonized by serine/threonine kinase PAK4.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.300

PAK4 functions in tumor necrosis factor (TNF) alpha-induced survival pathways by facilitating TRADD binding to the TNF receptor

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.300

A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras

21 January 2018

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CDK2 phosphorylation of Smad2 disrupts TGF-beta transcriptional regulation in resistant primary bone marrow myeloma cells.

21 January 2018

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Phospho-control of TGF-beta superfamily signaling

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.300

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases

21 January 2018

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Hepatocyte growth factor inhibits epithelial to myofibroblast transition in lung cells via Smad7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.300

TGF-beta and HGF transmit the signals through JNK-dependent Smad2/3 phosphorylation at the linker regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.300

p21-Activated kinase 2 (PAK2) inhibits TGF-β signaling in Madin-Darby canine kidney (MDCK) epithelial cells by interfering with the receptor-Smad interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.300

Decreased levels of active SMAD2 correlate with poor prognosis in gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.300

P21-activated kinase 4 overexpression in metastatic gastric cancer patients

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2013.300

A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-beta in pancreatic carcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.300

Ubc9 promotes the stability of Smad4 and the nuclear accumulation of Smad1 in osteoblast-like Saos-2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.300

Growth suppression of human carcinoma cells by reintroduction of the p300 coactivator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.300

Inhibitory machinery for the TGF-β family signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.300

The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.300

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2013.300