(Q37916975)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21839702%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

review article

1 reference

title

Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21839702%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

author name string

Bhagelu Ram Achyut

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21839702%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

Li Yang

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21839702%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

language of work or name

English

0 references

publication date

11 August 2011

1 reference

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10 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21839702%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

volume

141

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21839702%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21839702%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

page(s)

1167-1178

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Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

10 February 2020

cites work

1 reference

12 December 2020

Transforming growth factor betas and their signaling receptors in human hepatocellular carcinoma

1 reference

12 December 2020

Gene mutation of transforming growth factor beta1 type II receptor in hepatocellular carcinoma

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12 December 2020

Smad2 and Smad4 gene mutations in hepatocellular carcinoma

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12 December 2020

Accumulated frameshift mutations at coding nucleotide repeats during the progression of gastric carcinoma with microsatellite instability.

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12 December 2020

Transcriptional repression of the transforming growth factor-beta type I receptor gene by DNA methylation results in the development of TGF-beta resistance in human gastric cancer

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12 December 2020

Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice

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12 December 2020

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

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12 December 2020

Expression of transforming growth factor beta-1 in gastric cancer and in the gastric mucosa of first-degree relatives of patients with gastric cancer

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12 December 2020

Genetic progression in microsatellite instability high (MSI-H) colon cancers correlates with clinico-pathological parameters: A study of the TGRbetaRII, BAX, hMSH3, hMSH6, IGFIIR and BLM genes.

1 reference

12 December 2020

The transforming growth factor-beta signaling pathway in tumorigenesis.

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12 December 2020

Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression

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12 December 2020

TGF-beta signaling in cancer--a double-edged sword

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12 December 2020

c-myc is a downstream target of the Smad pathway

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12 December 2020

TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase

1 reference

12 December 2020

TGF-beta1 acts as a tumor suppressor of human malignant keratinocytes independently of Smad 4 expression and ligand-induced G(1) arrest

1 reference

12 December 2020

Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells

1 reference

12 December 2020

Changes of TGFbeta1 and TGFbetaRII expression in esophageal precancerous and cancerous lesions: a study of a high-risk population in Henan, northern China

1 reference

12 December 2020

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

1 reference

12 December 2020

Metastasis to bone: causes, consequences and therapeutic opportunities

1 reference

12 December 2020

Decreased Smad4 expression in the transforming growth factor-beta signaling pathway during progression of esophageal squamous cell carcinoma

1 reference

12 December 2020

Elimination of colon cancer in germ-free transforming growth factor beta 1-deficient mice

1 reference

12 December 2020

Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta

1 reference

12 December 2020

Soluble type II transforming growth factor-beta receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis.

1 reference

12 December 2020

Reduced expression of transforming growth factor-beta receptors is an unfavorable prognostic factor in human esophageal squamous cell carcinoma

1 reference

12 December 2020

SMAD7 is a prognostic marker in patients with colorectal cancer

1 reference

12 December 2020

BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury

1 reference

12 December 2020

The two faces of transforming growth factor beta in carcinogenesis

1 reference

12 December 2020

Expression of transforming growth factor betas and their signaling receptors in stone-containing intrahepatic bile ducts and cholangiocarcinoma

1 reference

12 December 2020

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

1 reference

12 December 2020

A Failure of Transforming Growth Factor-β1 Negative Regulation Maintains Sustained NF-κB Activation in Gut Inflammation

1 reference

12 December 2020

Transforming Growth Factor-Beta in Osteolytic Breast Cancer Bone Metastases

1 reference

12 December 2020

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

1 reference

12 December 2020

Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer

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12 December 2020

1 reference

12 December 2020

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

1 reference

12 December 2020

Stromal fibroblasts in cancer initiation and progression

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12 December 2020

Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors

1 reference

12 December 2020

A distinct "side population" of cells in human tumor cells: implications for tumor biology and therapy

1 reference

12 December 2020

Altered expression of TGF-beta receptors in hepatocellular carcinoma--effects of a constitutively active TGF-beta type I receptor mutant

1 reference

12 December 2020

Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis

1 reference

12 December 2020

Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

1 reference

12 December 2020

A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers.

1 reference

12 December 2020

VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche

1 reference

12 December 2020

Inhibition of TGFbeta signaling in cancer therapy

1 reference

12 December 2020

Helicobacter infection is required for inflammation and colon cancer in SMAD3-deficient mice

1 reference

12 December 2020

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

1 reference

12 December 2020

Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma

1 reference

12 December 2020

Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice

1 reference

12 December 2020

Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer

1 reference

12 December 2020

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

1 reference

12 December 2020

Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment.

1 reference

12 December 2020

Transforming growth factor-beta promotes invasion in tumorigenic but not in nontumorigenic human prostatic epithelial cells.

1 reference

12 December 2020

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome

1 reference

12 December 2020

Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.

1 reference

12 December 2020

Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression

1 reference

12 December 2020

Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis

1 reference

12 December 2020

High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene

1 reference

12 December 2020

Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling.

1 reference

12 December 2020

Stable Overexpression of Smad7 in Human Melanoma Cells Impairs Bone Metastasis

1 reference

12 December 2020

Molecular definition of breast tumor heterogeneity

1 reference

12 December 2020

Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways

1 reference

12 December 2020

SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

1 reference

12 December 2020

Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression.

1 reference

12 December 2020

Tissue level, activation and cellular localisation of TGF-beta1 and association with survival in gastric cancer patients

1 reference

12 December 2020

Anti-cancer therapies targeting the tumor stroma

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12 December 2020

Transforming growth factor-beta can suppress tumorigenesis through effects on the putative cancer stem or early progenitor cell and committed progeny in a breast cancer xenograft model

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12 December 2020

Basics of TGF-beta and pancreatic cancer

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12 December 2020

Pancreatic cancer-associated stroma production

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12 December 2020

Dynamics of the immune reaction to pancreatic cancer from inception to invasion

1 reference

12 December 2020

Transforming growth factor-beta promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1

1 reference

12 December 2020

Antisense therapeutics for tumor treatment: the TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors.

1 reference

12 December 2020

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

1 reference

12 December 2020

Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability.

1 reference

12 December 2020

HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion

1 reference

12 December 2020

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

1 reference

12 December 2020

LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis

1 reference

12 December 2020

1 reference

12 December 2020

The epithelial-mesenchymal transition generates cells with properties of stem cells

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12 December 2020

Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells.

1 reference

12 December 2020

1 reference

12 December 2020

T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance

1 reference

12 December 2020

Overexpression of interleukin-1beta induces gastric inflammation and cancer and mobilizes myeloid-derived suppressor cells in mice.

1 reference

12 December 2020

Role of Ras signaling in the induction of snail by transforming growth factor-beta.

1 reference

12 December 2020

Smad4 haploinsufficiency: a matter of dosage

1 reference

12 December 2020

TGFbeta-stimulated Smad1/5 phosphorylation requires the ALK5 L45 loop and mediates the pro-migratory TGFbeta switch

1 reference

12 December 2020

Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche

1 reference

12 December 2020

Inducible cutaneous inflammation reveals a protumorigenic role for keratinocyte CXCR2 in skin carcinogenesis

1 reference

12 December 2020

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

1 reference

12 December 2020

Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer

1 reference

12 December 2020

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits

1 reference

12 December 2020

Microenvironmental regulation of metastasis

1 reference

12 December 2020

Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells

1 reference

12 December 2020

The metastatic niche: adapting the foreign soil

1 reference

12 December 2020

A Mutant-p53/Smad complex opposes p63 to empower TGFbeta-induced metastasis

1 reference

12 December 2020

TGF-beta increases glioma-initiating cell self-renewal through the induction of LIF in human glioblastoma.

1 reference

12 December 2020

Overexpression and interactions of interleukin-10, transforming growth factor beta, and vascular endothelial growth factor in esophageal squamous cell carcinoma

1 reference

12 December 2020

Abrogation of TGF-beta signaling enhances chemokine production and correlates with prognosis in human breast cancer

1 reference

12 December 2020

The basics of epithelial-mesenchymal transition

1 reference

12 December 2020

Trabedersen, a TGFbeta2-specific antisense oligonucleotide for the treatment of malignant gliomas and other tumors overexpressing TGFbeta2.

1 reference

12 December 2020

SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer

1 reference

12 December 2020

Inhibition of transforming growth factor beta receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation

1 reference

12 December 2020

Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN

1 reference

12 December 2020

Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation

1 reference

12 December 2020

Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti-transforming growth factor-beta monoclonal antibody

1 reference

12 December 2020

Autocrine TGF-beta signaling maintains tumorigenicity of glioma-initiating cells through Sry-related HMG-box factors.

1 reference

12 December 2020

Autophagy is activated by TGF-beta and potentiates TGF-beta-mediated growth inhibition in human hepatocellular carcinoma cells.

1 reference

12 December 2020

Transforming growth factor-beta: a target for cancer therapy

1 reference

12 December 2020

Application of T cell-based transcriptomics to identify three candidate biomarkers for monitoring anti-TGFβR therapy

1 reference

12 December 2020

Anti-transforming growth factor beta receptor II antibody has therapeutic efficacy against primary tumor growth and metastasis through multieffects on cancer, stroma, and immune cells

1 reference

12 December 2020

Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.

1 reference

12 December 2020

Epigenetic Targeting of Transforming Growth Factor β Receptor II and Implications for Cancer Therapy

1 reference

12 December 2020

TGFbeta and cancer metastasis: an inflammation link.

1 reference

12 December 2020

TGFbeta signalling: a complex web in cancer progression

1 reference

12 December 2020

Constitutively decreased TGFBR1 allelic expression is a common finding in colorectal cancer and is associated with three TGFBR1 SNPs

1 reference

12 December 2020

Tgf-beta signaling alterations and colon cancer

1 reference

12 December 2020

Reduced transforming growth factor-beta receptor II expression in hepatocellular carcinoma correlates with intrahepatic metastasis.

1 reference

12 December 2020

Micro-RNA-21 regulates TGF-β-induced myofibroblast differentiation by targeting PDCD4 in tumor-stroma interaction

1 reference

12 December 2020

TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression

1 reference

12 December 2020

Transforming growth factor-beta induces senescence in hepatocellular carcinoma cells and inhibits tumor growth.

1 reference

12 December 2020

The polarization of immune cells in the tumour environment by TGFbeta

1 reference

12 December 2020

Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lung

1 reference

12 December 2020

Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts

1 reference

12 December 2020

Transforming growth factor β signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity

1 reference

12 December 2020

Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.

1 reference

12 December 2020

Inhibiting TGF-β signaling in hepatocellular carcinoma

1 reference

12 December 2020

Transforming growth factor-β decreases the cancer-initiating cell population within diffuse-type gastric carcinoma cells.

1 reference

12 December 2020

TGF-β Receptor Inhibitors Target the CD44(high)/Id1(high) Glioma-Initiating Cell Population in Human Glioblastoma

1 reference

12 December 2020

A digest on the role of the tumor microenvironment in gastrointestinal cancers

1 reference

12 December 2020

Switching TGFβ from a tumor suppressor to a tumor promoter.

1 reference

12 December 2020

The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts.

1 reference

12 December 2020

Altered TGF-β signaling in a subpopulation of human stromal cells promotes prostatic carcinogenesis.

1 reference

12 December 2020

Dysfunctional transforming growth factor-β signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma

1 reference

12 December 2020

Downregulation of TGF-beta receptor types II and III in oral squamous cell carcinoma and oral carcinoma-associated fibroblasts

1 reference

12 December 2020

Transforming growth factor-beta 2 gene silencing with trabedersen (AP 12009) in pancreatic cancer

1 reference

12 December 2020

Hallmarks of Cancer: The Next Generation

1 reference

12 December 2020

An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition

1 reference

12 December 2020

Deletion of p120-catenin results in a tumor microenvironment with inflammation and cancer that establishes it as a tumor suppressor gene

1 reference

12 December 2020

TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells

1 reference

12 December 2020

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

1 reference

12 December 2020

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer

1 reference

12 December 2020

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

1 reference

12 December 2020

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

12 December 2020

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

1 reference

12 December 2020

Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes

1 reference

12 December 2020

Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.

1 reference

12 December 2020

10.1053/J.GASTRO.2011.07.048

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21839702%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21839702%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

PubMed publication ID

21839702

1 reference