(Q28296790)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15581484%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

review article

1 reference

title

The prolyl hydroxylase enzymes that act as oxygen sensors regulating destruction of hypoxia-inducible factor alpha (English)

1 reference

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5 January 2020

0 references

3

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5 January 2020

Chris Pugh

4

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5 January 2020

Patrick H. Maxwell

5

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5 January 2020

author name string

Carsten Willam

1

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5 January 2020

Lynn G Nicholls

2

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5 January 2020

language of work or name

English

0 references

publication date

1 January 2004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15581484%20AND%20SRC:MED&resulttype=core&format=json

Advances in Enzyme Regulation

5 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15581484%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

volume

44

1 reference

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5 January 2020

page(s)

75-92

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15581484%20AND%20SRC:MED&resulttype=core&format=json

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

5 January 2020

cites work

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24 May 2022

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Mutations of the VHL tumour suppressor gene in renal carcinoma

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Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

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Loss of pVHL is sufficient to cause HIF dysregulation in primary cells but does not promote tumor growth

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Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation

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12 October 2022

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Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

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12 October 2022

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HIF activation identifies early lesions in VHL kidneys: evidence for site-specific tumor suppressor function in the nephron

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12 October 2022

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Mapping, characterization, and expression analysis of the SM-20 human homologue, c1orf12, and identification of a novel related gene, SCAND2

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12 October 2022

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

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12 October 2022

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation

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12 October 2022

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Novel estrogen and tamoxifen induced genes identified by SAGE (Serial Analysis of Gene Expression)

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12 October 2022

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Characterization and comparative analysis of the EGLN gene family

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12 October 2022

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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12 October 2022

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Unresponsiveness of erythropoietin-producing cells to cyanide

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Pseudomonas aeruginosa PAO1 kills Caenorhabditis elegans by cyanide poisoning

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

On the Origin of Cancer Cells

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12 October 2022

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Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Activation of the HIF pathway in cancer

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

HIF-1alpha is essential for myeloid cell-mediated inflammation

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Structural and mechanistic studies on 2-oxoglutarate-dependent oxygenases and related enzymes

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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12 October 2022

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Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

The VHL tumour-suppressor gene paradigm

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12 October 2022

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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12 October 2022

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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12 October 2022

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Intracellular localisation of human HIF-1 alpha hydroxylases: implications for oxygen sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex

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12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Identification of the RNA polymerase II subunit hsRPB7 as a novel target of the von Hippel-Lindau protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Lethal paralysis of Caenorhabditis elegans by Pseudomonas aeruginosa

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

An essential role for p300/CBP in the cellular response to hypoxia

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Mammalian EGLN genes have distinct patterns of mRNA expression and regulation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Identification of the von Hippel-Lindau disease tumor suppressor gene

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Regulation of the erythropoietin gene: evidence that the oxygen sensor is a heme protein

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Peptide blockade of HIFalpha degradation modulates cellular metabolism and angiogenesis

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Contrasting effects on HIF-1alpha regulation by disease-causing pVHL mutations correlate with patterns of tumourigenesis in von Hippel-Lindau disease.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

HIF-1-dependent transcriptional activity is required for oxygen-mediated HIF-1alpha degradation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Mesenchymal-epithelial transition in the developing metanephric kidney: gene expression study by differential display

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Falkor, a novel cell growth regulator isolated by a functional genetic screen

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Identification of the renal erythropoietin-producing cells using transgenic mice

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1.

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

EPAS1 trans-activation during hypoxia requires p42/p44 MAPK

1 reference

12 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.ADVENZREG.2003.11.017

Identifiers

DOI

10.1016/J.ADVENZREG.2003.11.017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15581484%20AND%20SRC:MED&resulttype=core&format=json

5 January 2020

1 reference