(Q28301859)

2

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F Charles Brunicardi

3

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John Goss

4

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Kaiyi Li

ATM activation in normal human tissues and testicular cancer

5

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language of work or name

English

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publication date

April 2009

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published in

World Journal of Surgery

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volume

33

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issue

4

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page(s)

661-6

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cites work

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00268-008-9840-1

Poly(ADP-ribose) polymerase inhibitors

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00268-008-9840-1

PARP inhibitors for cancer therapy.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS00268-008-9840-1

Evidence for the Direct Binding of Phosphorylated p53 to Sites of DNA BreaksIn vivo

21 January 2018

1 reference

12 December 2020

Rapid destruction of human Cdc25A in response to DNA damage

1 reference

12 December 2020

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

12 December 2020

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

1 reference

12 December 2020

Nucleotide excision repair and cancer

1 reference

12 December 2020

The cellular response to general and programmed DNA double strand breaks

1 reference

12 December 2020

Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

1 reference

12 December 2020

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

1 reference

12 December 2020

Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor

1 reference

12 December 2020

DNA strand break repair and human genetic disease

1 reference

12 December 2020

Initiating cellular stress responses

1 reference

12 December 2020

G2 checkpoint abrogators as anticancer drugs

1 reference

12 December 2020

Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

1 reference

12 December 2020

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

1 reference

12 December 2020

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

1 reference

12 December 2020

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

1 reference

12 December 2020

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

12 December 2020

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

1 reference

12 December 2020

The Fanconi road to cancer

1 reference

12 December 2020

Cell death: critical control points

1 reference

12 December 2020

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

1 reference

12 December 2020

DNA repair deficiency as a therapeutic target in cancer

1 reference

12 December 2020

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

12 December 2020

BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

1 reference

12 December 2020

Cancer in xeroderma pigmentosum and related disorders of DNA repair

1 reference

12 December 2020

Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

1 reference

12 December 2020

Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

1 reference

12 December 2020

Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

1 reference

12 December 2020

Decision making by p53: life, death and cancer

1 reference

12 December 2020

The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

1 reference

12 December 2020

The concept of synthetic lethality in the context of anticancer therapy

1 reference

12 December 2020

Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

1 reference

12 December 2020

The cellular response to DNA double-strand breaks: defining the sensors and mediators

1 reference

12 December 2020

1 reference

12 December 2020

Targeting the checkpoint kinases: chemosensitization versus chemoprotection

1 reference

12 December 2020

1 reference

12 December 2020

Two faces of p53: aging and tumor suppression

1 reference

12 December 2020

The complexity of p53 stabilization and activation

1 reference

12 December 2020

The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity

1 reference

12 December 2020

ATM signaling and 53BP1.

1 reference

12 December 2020

53BP1, an activator of ATM in response to DNA damage

1 reference

12 December 2020

Emerging cancer therapeutic opportunities target DNA-repair systems

1 reference

12 December 2020

Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.

1 reference

12 December 2020

Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology

1 reference

12 December 2020

p53 moves to mitochondria: a turn on the path to apoptosis.

1 reference

12 December 2020

The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

1 reference

12 December 2020

Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

1 reference

12 December 2020

Profiling of UV-induced ATM/ATR signaling pathways.

1 reference

12 December 2020

Instability and decay of the primary structure of DNA

1 reference

12 December 2020

Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

1 reference

12 December 2020

Genotoxic and non-genotoxic pathways of p53 induction

1 reference

12 December 2020

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

1 reference

12 December 2020

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

1 reference

12 December 2020

Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis

1 reference

12 December 2020

DNA double-strand break repair

1 reference

12 December 2020

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

12 December 2020

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

1 reference

12 December 2020

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

1 reference

12 December 2020

Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors

1 reference

12 December 2020

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

1 reference

12 December 2020

Targeted cancer therapies based on the inhibition of DNA strand break repair

1 reference

12 December 2020

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

1 reference

12 December 2020

Mutator pathways unleashed by epigenetic silencing in human cancer

1 reference

12 December 2020

DNA helicases, genomic instability, and human genetic disease

1 reference

12 December 2020

Running interference: pace picks up on synthetic lethality research

1 reference

12 December 2020

Interfaces between the detection, signaling, and repair of DNA damage

1 reference

12 December 2020

Genome maintenance mechanisms for preventing cancer

1 reference

12 December 2020

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

1 reference

12 December 2020

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

1 reference

12 December 2020