(Q22242850)

PubMed

PubMed publication ID

7 February 2023

F. V. Jacinto

1

Filipe V

Jacinto

1 reference

PubMed

PubMed publication ID

17412712

The emerging role of DNA repair proteins as predictive, prognostic and therapeutic targets in cancer

7 February 2023

language of work or name

English

0 references

publication date

4 April 2007

0 references

published in

Mutagenesis

0 references

volume

22

0 references

issue

4

0 references

page(s)

247-253

0 references

cites work

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Genome maintenance mechanisms for preventing cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

DNA hypermethylation in tumorigenesis: epigenetics joins genetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Epigenetic differences arise during the lifetime of monozygotic twins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Epigenetic stem cell signature in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

The Polycomb group protein EZH2 directly controls DNA methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Association of BRCA1 with Rad51 in mitotic and meiotic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

A targeted disruption of the murine Brca1 gene causes gamma-irradiation hypersensitivity and genetic instability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Cancer susceptibility and the functions of BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Mouse models of BRCA1 and BRCA2 deficiency: past lessons, current understanding and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Somatic mutations in the BRCA1 gene in sporadic ovarian tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Novel p53 mutants selected in BRCA-associated tumours which dissociate transformation suppression from other wild-type p53 functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Collaboration of Brca1 and Chk2 in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Structure and function of the components of the human DNA mismatch repair system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

The multifaceted mismatch-repair system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Clues to the pathogenesis of familial colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Microsatellite instability in cancer of the proximal colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Genetic studies of the lac repressor. III. Additional correlation of mutational sites with specific amino acid residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Methylation of O(6)-methylguanine-DNA methyltransferase gene is associated significantly with K-ras mutation, lymph node invasion, tumor staging, and disease free survival in patients with gastric carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

The IARC TP53 database: new online mutation analysis and recommendations to users

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

5-Methylcytosine as an Endogenous Mutagen in the Human LDL Receptor and p53 Genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1-DNA adducts and p53 mutation in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Lessons from human progeroid syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Positional cloning of the Werner's syndrome gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Junction of RecQ helicase biochemistry and human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Enzymatic mechanism of the WRN helicase/nuclease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Deficient DNA repair in the human progeroid disorder, Werner syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

p53 Modulates the exonuclease activity of Werner syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Highly penetrant hereditary cancer syndromes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Current advances in unraveling the function of the Werner syndrome protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

Frameshift mutator mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

A specific CpG methylation pattern of the MGMT promoter region associated with reduced MGMT expression in primary colorectal cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

7 January 2021

Analysis of helicase gene mutations in Japanese Werner's syndrome patients

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

7 January 2021

Microsatellite instability and mismatch repair defects in cancer

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

7 January 2021

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

7 January 2021

Impaired nuclear localization of defective DNA helicases in Werner's syndrome

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

7 January 2021

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

7 January 2021

p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

7 January 2021

Two novel regions of interstitial deletion on chromosome 8p in colorectal cancer

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

7 January 2021

Methylation of the BRCA1 promoter region in sporadic breast and ovarian cancer: correlation with disease characteristics

1 reference

https://api.crossref.org/works/10.1093%2FMUTAGE%2FGEM009

7 January 2021