(Q36515727)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16793395%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

Enzymatic mechanism of the WRN helicase/nuclease (English)

1 reference

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25 December 2019

2

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25 December 2019

3

Vilhelm A Bohr

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16793395%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

author name string

Robert M Brosh

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16793395%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

language of work or name

English

0 references

publication date

1 January 2006

1 reference

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25 December 2019

published in

Methods in Enzymology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16793395%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

volume

409

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16793395%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

page(s)

52-85

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16793395%20AND%20SRC:MED&resulttype=core&format=json

Regulation of WRN helicase activity in human base excision repair

25 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

WRN interacts physically and functionally with the recombination mediator protein RAD52

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Single-turnover kinetics of helicase-catalyzed DNA unwinding monitored continuously by fluorescence energy transfer.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

DNA damage-induced translocation of the Werner helicase is regulated by acetylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Unwinding of a DNA triple helix by the Werner and Bloom syndrome helicases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

p53 Modulates the exonuclease activity of Werner syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Functional and physical interaction between WRN helicase and human replication protein A

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Biochemical characterization of the DNA substrate specificity of Werner syndrome helicase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Roles of the Werner syndrome protein in pathways required for maintenance of genome stability

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Linkage between Werner syndrome protein and the Mre11 complex via Nbs1.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Werner syndrome protein phosphorylation by abl tyrosine kinase regulates its activity and distribution

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Biochemical and kinetic characterization of the DNA helicase and exonuclease activities of werner syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Characterization of the DNA-unwinding activity of human RECQ1, a helicase specifically stimulated by human replication protein A.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Demonstration of unidirectional single-stranded DNA translocation by PcrA helicase: measurement of step size and translocation speed

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Physical and functional mapping of the replication protein a interaction domain of the werner and bloom syndrome helicases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Inhibition of Werner syndrome helicase activity by benzo[c]phenanthrene diol epoxide dA adducts in DNA is both strand-and stereoisomer-dependent

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

DNA double-strand break repair

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

The Werner syndrome protein is a DNA helicase

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Characterization of the human and mouse WRN 3'-->5' exonuclease

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

The 3′-tail of a forked-duplex sterically determines whether one or two DNA strands pass through the central channel of a replication-fork helicase 1 1Edited by M. Gottesman

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Covalent modification of the Werner's syndrome gene product with the ubiquitin-related protein, SUMO-1

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Pathways and functions of the Werner syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Functional interaction between Ku and the werner syndrome protein in DNA end processing

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Requirements for the nucleolytic processing of DNA ends by the Werner syndrome protein-Ku70/80 complex

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Selective blockage of the 3'-->5' exonuclease activity of WRN protein by certain oxidative modifications and bulky lesions in DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

DNA helicases: enzymes with essential roles in all aspects of DNA metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5'-biotinylated oligonucleotides but not from 3'-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

DNA helicases displace streptavidin from biotin-labeled oligonucleotides

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Enzymatic and DNA binding properties of purified WRN protein: high affinity binding to single-stranded DNA but not to DNA damage induced by 4NQO.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Current advances in unraveling the function of the Werner syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Werner's syndrome protein is phosphorylated in an ATR/ATM-dependent manner following replication arrest and DNA damage induced during the S phase of the cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Homologous recombination resolution defect in werner syndrome

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

The N-terminal domain of the large subunit of human replication protein A binds to Werner syndrome protein and stimulates helicase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

p53 modulates RPA-dependent and RPA-independent WRN helicase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

The Bloom's syndrome helicase unwinds G4 DNA

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

DNA helicase activity in Werner's syndrome gene product synthesized in a baculovirus system

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Interactions of DNA helicases with damaged DNA: possible biological consequences

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Werner syndrome protein contains three structure-specific DNA binding domains

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

The processing of Holliday junctions by BLM and WRN helicases is regulated by p53

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

RecQ family members combine strand pairing and unwinding activities to catalyze strand exchange

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Junction of RecQ helicase biochemistry and human disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Biochemical analysis of the DNA unwinding and strand annealing activities catalyzed by human RECQ1.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

Positional cloning of the Werner's syndrome gene

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2805%2909004-X

7 January 2021

10.1016/S0076-6879(05)09004-X

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16793395%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference