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Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions
scientific article
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instance of
scholarly article
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
title
Targeting mutants of PTEN reveal distinct subsets of tumour suppressor functions
(English)
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
author
Nick R. Leslie
series ordinal
1
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
Alexander Gray
series ordinal
3
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
author name string
D Bennett
series ordinal
2
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
I Pass
series ordinal
4
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
K Hoang-Xuan
series ordinal
5
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
C P Downes
series ordinal
6
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
language of work or name
English
0 references
publication date
1 July 2001
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
number of pages
9
1 reference
based on heuristic
inferred from page(s)
published in
Biochemical Journal
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
volume
357
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
issue
Pt 2
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
page(s)
427-435
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
cites work
The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
Localized Rac activation dynamics visualized in living cells
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PubMed Central
reference URL
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20 March 2017
Phosphorylation of the PTEN tail regulates protein stability and function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
The PI3K-PDK1 connection: more than just a road to PKB
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20 March 2017
Threonine phosphorylation of the MMAC1/PTEN PDZ binding domain both inhibits and stimulates PDZ binding
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
The lipid phosphatase activity of PTEN is critical for its tumor supressor function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
retrieved
20 March 2017
Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
retrieved
20 March 2017
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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20 March 2017
A role for nuclear PTEN in neuronal differentiation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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7 April 2017
New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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7 April 2017
Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
Mutations of the human PTEN gene
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
PTEN, a unique tumor suppressor gene
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
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stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
Analysis of the cellular functions of PTEN using catalytic domain and C-terminal mutations: differential effects of C-terminal deletion on signalling pathways downstream of phosphoinositide 3-kinase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
ERBB-2 overexpression confers PI 3' kinase-dependent invasion capacity on human mammary epithelial cells
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29 September 2017
Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
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29 September 2017
Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
Functional roles for fatty acylated amino-terminal domains in subcellular localization
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
PTEN: a tumour suppressor that functions as a phospholipid phosphatase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
A requirement for phosphatidylinositol 3-kinase in pseudopod extension
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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29 September 2017
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
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29 September 2017
Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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2 June 2018
Mutational analysis of the PTEN gene in gliomas: molecular and pathological correlations.
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2 June 2018
Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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2 June 2018
A novel, rapid, and highly sensitive mass assay for phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) and its application to measure insulin-stimulated PtdIns(3,4,5)P3 production in rat skeletal muscle in vivo
1 reference
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reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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2 June 2018
The inhibition of phosphoinositide synthesis and muscarinic-receptor-mediated phospholipase C activity by Li+ as secondary, selective, consequences of inositol depletion in 1321N1 cells
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2 June 2018
Activation of phosphoinositide 3-kinase is required for PDGF-stimulated membrane ruffling
1 reference
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PubMed Central
reference URL
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2 June 2018
PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase
1 reference
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PubMed Central
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2 June 2018
Stabilization and productive positioning roles of the C2 domain of PTEN tumor suppressor.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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27 November 2018
Tumor suppressor PTEN inhibition of cell invasion, migration, and growth: differential involvement of focal adhesion kinase and p130Cas.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1221969
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27 November 2018
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11439092
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Activation of phosphoinositide 3-OH kinase by the alpha6beta4 integrin promotes carcinoma invasion
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/11439092
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1042/0264-6021:3570427
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
Fatcat ID
release_nnksmiikcbg6diqvbpstmlgg24
0 references
PMC publication ID
1221969
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
PubMed publication ID
11439092
1 reference
stated in
Europe PubMed Central
PMC publication ID
1221969
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11439092%20AND%20SRC:MED&resulttype=core&format=json
retrieved
9 November 2019
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