(Q28485372)

English

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign

scientific article

In more languages

default for all languages

No label defined

No description defined

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign (English)

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

infectious disease

0 references

Trypanosoma brucei

0 references

1

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

3

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

8

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Jean-Robert Ioset

7

object named as

Jean-Robert Ioset

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

author name string

Jonathan B Baell

2

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Eric Chatelain

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Sarah R Moawad

5

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

Danny Ganame

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

language of work or name

0 references

publication date

29 November 2012

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PLoS Neglected Tropical Diseases

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

6

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

11

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

e1896

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

copyright license

Creative Commons Attribution 4.0 International

29 November 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

19 March 2017

A target-based high throughput screen yields Trypanosoma brucei hexokinase small molecule inhibitors with antiparasitic activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

19 March 2017

Do structurally similar molecules have similar biological activity?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

19 March 2017

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

19 March 2017

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

7 April 2017

Can the pharmaceutical industry reduce attrition rates?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

7 April 2017

Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

7 April 2017

Opportunities and Challenges in Antiparasitic Drug Discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

9 May 2017

The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Diamidines for human African trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Discovery of novel orally bioavailable oxaborole 6-carboxamides that demonstrate cure in a murine model of late-stage central nervous system african trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Trypanocidal drugs: mechanisms, resistance and new targets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

NECT trial: more than a small victory over sleeping sickness

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

The burden of human African trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

High failure rates of melarsoprol for sleeping sickness, Democratic Republic of Congo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

The mitochondrion is a site of trypanocidal action of the aromatic diamidine DB75 in bloodstream forms of Trypanosoma brucei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Eflornithine is safer than melarsoprol for the treatment of second-stage Trypanosoma brucei gambiense human African trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Synthesis and antileishmanial activities of novel 3-substituted quinolines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Assessment of the consistency of medicinal chemists in reviewing sets of compounds.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Cloning and analysis of Trypanosoma cruzi lanosterol 14alpha-demethylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Arsenicals (melarsoprol), pentamidine and suramin in the treatment of human African trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

The big and small of drug discovery. Biotech versus pharma: advantages and drawbacks in drug development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

The Alamar Blue assay to determine drug sensitivity of African trypanosomes (T.b. rhodesiense and T.b. gambiense) in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

The treatment of human African trypanosomiasis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Susceptibility of Plasmodium falciparum to five drugs: an in vitro study of isolates mainly from Thailand

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei, T. equiperdum, T. evansi, T. rhodesiense and T. gambiense

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

Differential expression of the oligomycin-sensitive ATPase in bloodstream forms of Trypanosoma brucei brucei

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

29 September 2017

A new rapid and simple non-radioactive assay to monitor and determine the proliferation of lymphocytes: an alternative to [3H]thymidine incorporation assay

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

2 June 2018

Cultivation of Trypanosoma brucei sspp. in semi-defined and defined media

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

2 June 2018

Continuous cultivation of Trypanosoma brucei blood stream forms in a medium containing a low concentration of serum protein without feeder cell layers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

2 June 2018

New culture medium for maintenance of tsetse tissues and growth of trypanosomatids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

2 June 2018

Nifurtimox-eflornithine combination therapy for second-stage Trypanosoma brucei gambiense sleeping sickness: a randomized clinical trial in Congo

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001896

21 January 2018

Development of an Alamar Blue viability assay in 384-well format for high throughput whole cell screening of Trypanosoma brucei brucei bloodstream form strain 427.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001896

21 January 2018

Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001896

21 January 2018

A simple colorimetric method to screen drug cytotoxicity against Leishmania using the dye Alamar Blue.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001896

21 January 2018

Leishmania inactivation in human pheresis platelets by a psoralen (amotosalen HCl) and long-wavelength ultraviolet irradiation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001896

21 January 2018

Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001896

21 January 2018

In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001896

21 January 2018

Discovery of oxazolo[4,5-b]pyridines and related heterocyclic analogs as novel SIRT1 activators

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PNTD.0001896

21 January 2018

A new fluorometric assay for cytotoxicity measurements in-vitro.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510080

27 November 2018

Acetylation-dependent ADP-ribosylation by Trypanosoma brucei Sir2

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical shift assignment and conformational analysis of monoalkylated acylguanidines

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antibiotics as tools for metabolic studies. I. A survey of toxic antibiotics in respiratory, phosphorylative and glycolytic systems

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of suramin on the function and structure of the adrenal cortex in the cynomolgus monkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mediation sans litigation in malpractice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trypanosome and animal lanosterol synthases use different catalytic motifs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23209849

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PNTD.0001896

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23209849%20AND%20SRC:MED&resulttype=core&format=json

19 February 2020

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28485372&oldid=2088625228"