(Q28534702)

English

Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin

scientific article (publication date: 2013)

In more languages

Statements

scholarly article

0 references

Expanding the druggable space of the LSD1/CoREST epigenetic target: new potential binding regions for drug-like molecules, peptides, protein partners, and chromatin (English)

0 references

object named as

A Ganesan

7

0 references

object named as

Andrea Mattevi

8

0 references

author name string

James C Robertson

1

0 references

Nate C Hurley

2

0 references

Marcello Tortorici

3

0 references

Giuseppe Ciossani

4

0 references

Maria Teresa Borrello

5

0 references

Nadeem A Vellore

6

0 references

Riccardo Baron

9

0 references

language of work or name

0 references

publication date

2013

0 references

PLOS Computational Biology

0 references

9

0 references

7

0 references

e1003158

0 references

copyright license

Creative Commons Attribution 4.0 International

18 July 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Protein recognition by short peptide reversible inhibitors of the chromatin-modifying LSD1/CoREST lysine demethylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

LSD1 inhibition: a therapeutic strategy in cancer?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

LSD1/CoREST is an allosteric nanoscale clamp regulated by H3-histone-tail molecular recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Protein flexibility in docking and surface mapping

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Overview of the CCP4 suite and current developments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase LSD1-CoREST Complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Structural basis of LSD1-CoREST selectivity in histone H3 recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Integrated Modeling Program, Applied Chemical Theory (IMPACT)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

GROMACS: fast, flexible, and free

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Regulation of LSD1 histone demethylase activity by its associated factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

6 April 2017

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Coordinated histone modifications mediated by a CtBP co-repressor complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

CoREST is an integral component of the CoREST- human histone deacetylase complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

VMD: visual molecular dynamics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Gene duplications in the structural evolution of chymotrypsin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

19 March 2017

Epigenetic protein families: a new frontier for drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

7 April 2017

A biomolecular force field based on the free enthalpy of hydration and solvation: the GROMOS force-field parameter sets 53A5 and 53A6

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

7 April 2017

Druggable protein interaction sites are more predisposed to surface pocket formation than the rest of the protein surface

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Relationship between hot spot residues and ligand binding hot spots in protein-protein interfaces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

FTMAP: extended protein mapping with user-selected probe molecules

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

LSD1/CoREST reversible opening-closing dynamics: discovery of a nanoscale clamp for chromatin and protein binding.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

FTSite: high accuracy detection of ligand binding sites on unbound protein structures

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Lysine demethylases inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Targeting Histone Demethylases: A New Avenue for the Fight against Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Romidepsin: a novel histone deacetylase inhibitor for cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Predictive power of molecular dynamics receptor structures in virtual screening

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Total syntheses of the histone deacetylase inhibitors largazole and 2-epi-largazole: application of N-heterocyclic carbene mediated acylations in complex molecule synthesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Full protein flexibility is essential for proper hot-spot mapping.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Identifying and characterizing binding sites and assessing druggability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Development of vorinostat: current applications and future perspectives for cancer therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Fragment-based identification of druggable 'hot spots' of proteins using Fourier domain correlation techniques

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Novel druggable hot spots in avian influenza neuraminidase H5N1 revealed by computational solvent mapping of a reduced and representative receptor ensemble.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3715402

29 September 2017

Human histone demethylase LSD1 reads the histone code

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003158

21 January 2018

Structural basis for CoREST-dependent demethylation of nucleosomes by the human LSD1 histone demethylase.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003158

21 January 2018

On the use of molecular dynamics receptor conformations for virtual screening

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003158

21 January 2018

Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003158

21 January 2018

Transient Pockets on Protein Surfaces Involved in Protein−Protein Interaction

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1003158

21 January 2018

Target watch: Drugging the epigenome

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874194

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein-protein interaction at crystal contacts

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874194

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New method for fast and accurate binding-site identification and analysis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874194

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Folding-unfolding thermodynamics of a beta-heptapeptide from equilibrium simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874194

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PCBI.1003158

0 references

DBLP publication ID

journals/ploscb/RobertsonHTCBVGMB13

1 reference

DBLP Dataset 2021-01-02

28 January 2021

0 references

0 references

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q28534702&oldid=1864400044"