(Q28546170)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

title

Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

0 references

1 reference

Rasheduzzaman Chowdhury

6

1 reference

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18 February 2020

Christopher J. Schofield

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Ivanhoe K. H. Leung

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Anna M Rydzik

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Akane Kawamura

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Chris Pugh

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Peter J. Ratcliffe

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

13

Timothy D W Claridge

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

4

Anthony Tumber

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

1

Mun Chiang Chan

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

8

Marina Demetriades

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

10

James Holt-Martyn

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

12

Tammie Bishop

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

author name string

Onur Atasoylu

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Emma Hodson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Verónica Gómez-Pérez

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

Ya-Min Tian

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

language of work or name

English

0 references

publication date

6 July 2015

1 reference

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18 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

volume

10

1 reference

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18 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

page(s)

e0132004

1 reference

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Creative Commons Attribution 4.0 International

18 February 2020

copyright license

start time

6 July 2015

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases

1 reference

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Structural basis for inhibition of the fat mass and obesity associated protein (FTO)

19 March 2017

1 reference

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Development and application of a fluoride-detection-based fluorescence assay for γ-butyrobetaine hydroxylase

19 March 2017

1 reference

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Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

19 March 2017

1 reference

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Overview of the CCP4 suite and current developments

19 March 2017

1 reference

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Inhibition of 2-oxoglutarate dependent oxygenases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor

19 March 2017

1 reference

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

19 March 2017

1 reference

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Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Phasercrystallographic software

19 March 2017

1 reference

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MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH)

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Asparagine beta-hydroxylation stabilizes the ankyrin repeat domain fold

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

HIF prolyl hydroxylase inhibition results in endogenous erythropoietin induction, erythrocytosis, and modest fetal hemoglobin expression in rhesus macaques

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2)

19 March 2017

1 reference

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Coot: model-building tools for molecular graphics

19 March 2017

1 reference

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

19 March 2017

1 reference

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Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

19 March 2017

1 reference

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A conserved family of prolyl-4-hydroxylases that modify HIF

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

19 March 2017

1 reference

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

19 March 2017

1 reference

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

19 March 2017

1 reference

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Solution structure and peptide binding of the SH3 domain from human Fyn

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

JmjC-domain-containing proteins and histone demethylation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Oxygen sensing by HIF hydroxylases

7 April 2017

1 reference

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5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

7 April 2017

1 reference

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Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Inhibition of hypoxia-inducible factor prolyl hydroxylase domain oxygen sensors: tricking the body into mounting orchestrated survival and repair responses

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Role of the jelly-roll fold in substrate binding by 2-oxoglutarate oxygenases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Hypoxia-inducible factor prolyl hydroxylase inhibition: robust new target or another big bust for stroke therapeutics?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

What has polar surface area ever done for drug discovery?

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Differential sensitivity of hypoxia inducible factor hydroxylation sites to hypoxia and hydroxylase inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Prolyl hydroxylase domain-containing protein inhibitors as stabilizers of hypoxia-inducible factor: small molecule-based therapeutics for anemia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Prolyl hydroxylase domain inhibitors: a route to HIF activation and neuroprotection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Water-based ligand screening for paramagnetic metalloproteins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected].

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4492579

Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function.

29 September 2017

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0132004

Monoclonal antibody-based screening assay for factor inhibiting hypoxia-inducible factor inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0132004

Carotid body hyperplasia and enhanced ventilatory responses to hypoxia in mice with heterozygous deficiency of PHD2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0132004

Target gene selectivity of hypoxia-inducible factor-alpha in renal cancer cells is conveyed by post-DNA-binding mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0132004

Estimation of blood-brain barrier crossing of drugs using molecular size and shape, and H-bonding descriptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0132004

10.1371/JOURNAL.PONE.0132004

21 January 2018

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

0 references

release_sct3rhtifvghda4utc3be42d5a

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/sct3rhtifvghda4utc3be42d5a

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

PubMed publication ID

26147748

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26147748%20AND%20SRC:MED&resulttype=core&format=json