(Q28564846)

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Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver--comparison with phase II xenobiotic metabolism

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PubMed publication ID

31 January 2017

Coffee and its chemopreventive components Kahweol and Cafestol increase the activity of O6-methylguanine-DNA methyltransferase in rat liver--comparison with phase II xenobiotic metabolism (English)

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PubMed publication ID

31 January 2017

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Wolfgang W. Huber

1

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PubMed publication ID

31 January 2017

Gerlinde Scharf

2

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PubMed publication ID

31 January 2017

Georg Nagel

3

1 reference

PubMed publication ID

31 January 2017

Sonja Prustomersky

4

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PubMed publication ID

31 January 2017

Rolf Schulte-Hermann

5

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PubMed publication ID

31 January 2017

Bernd Kaina

6

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PubMed publication ID

31 January 2017

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publication date

28 January 2003

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PubMed publication ID

31 January 2017

Mutation Research

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PubMed publication ID

31 January 2017

522

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PubMed publication ID

31 January 2017

1-2

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PubMed publication ID

31 January 2017

57–68

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PubMed publication ID

31 January 2017

Analysis of the content of the diterpenes cafestol and kahweol in coffee brews

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Levels of the Cholesterol-Elevating Diterpenes Cafestol and Kahweol in Various Coffee Brews

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The coffee-specific diterpenes cafestol and kahweol protect against aflatoxin B1-induced genotoxicity through a dual mechanism

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Kahweol and cafestol: inhibitors of hamster buccal pouch carcinogenesis

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Protective effects of coffee diterpenes against aflatoxin B1-induced genotoxicity: mechanisms in rat and human cells

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Placental glutathione S-transferase (GST-P) induction as a potential mechanism for the anti-carcinogenic effect of the coffee-specific components cafestol and kahweol.

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Effects of derivatives of kahweol and cafestol on the activity of glutathione S-transferase in mice

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Enhancement of the chemoprotective enzymes glucuronosyl transferase and glutathione transferase in specific organs of the rat by the coffee components kahweol and cafestol

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The coffee components kahweol and cafestol induce gamma-glutamylcysteine synthetase, the rate limiting enzyme of chemoprotective glutathione synthesis, in several organs of the rat.

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Transgenic systems in studies on genotoxicity of alkylating agents: critical lesions, thresholds and defense mechanisms.

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The prevention of thymic lymphomas in transgenic mice by human O6-alkylguanine-DNA alkyltransferase

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Reduced lung tumorigenesis in human methylguanine DNA--methyltransferase transgenic mice achieved by expression of transgene within the target cell.

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Transgenic expression of human MGMT protects against azoxymethane-induced aberrant crypt foci and G to A mutations in the K-ras oncogene of mouse colon

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O6-methylguanine-DNA methyltransferase protects against nitrosamine-induced hepatocarcinogenesis

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High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase.

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Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

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Low O6-alkylguanine DNA-alkyltransferase activity in normal colorectal tissue is associated with colorectal tumours containing a GC-->AT transition in the K-ras oncogene.

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O6-methylguanine-DNA methyltransferase activity in breast and brain tumors.

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A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

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Detoxication of base propenals and other alpha, beta-unsaturated aldehyde products of radical reactions and lipid peroxidation by human glutathione transferases

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Glutathione transferase activities in renal carcinomas and adjacent normal renal tissues: factors influencing renal carcinogenesis induced by xenobiotics

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A methodology for analysis of tissue sulfhydryl components

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Assay of gamma-glutamylcysteine synthetase and glutathione synthetase in erythrocytes by high-performance liquid chromatography with fluorimetric detection

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UDP-Glucuronosyltransferases

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Glucuronidation of N-hydroxy heterocyclic amines by human and rat liver microsomes.

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Alkyltransferase transgenic mice: probes of chemical carcinogenesis

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Spontaneous hepatocellular carcinoma is reduced in transgenic mice overexpressing human O6- methylguanine-DNA methyltransferase

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Fast repair of O6-ethylguanine, but not O6-methylguanine, in transcribed genes prevents mutation of H-ras in rat mammary tumorigenesis induced by ethylnitrosourea in place of methylnitrosourea

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Transfection and expression of human O6-methylguanine-DNA methyltransferase (MGMT) cDNA in Chinese hamster cells: the role of MGMT in protection against the genotoxic effects of alkylating agents

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Contribution of O6-alkylguanine and N-alkylpurines to the formation of sister chromatid exchanges, chromosomal aberrations, and gene mutations: new insights gained from studies of genetically engineered mammalian cell lines

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Protective effect of O6-methylguanine-DNA methyltransferase (MGMT) on the cytotoxic and recombinogenic activity of different antineoplastic drugs

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Suppression of human DNA alkylation-repair defects by Escherichia coli DNA-repair genes

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DNA repair methyltransferase (Mgmt) knockout mice are sensitive to the lethal effects of chemotherapeutic alkylating agents

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Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent

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Ionizing radiation induces O6-alkylguanine-DNA-alkyltransferase mRNA and activity in mouse tissues

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O6-Methylguanine methyltransferase activity is increased in rat tissues by ionising radiation

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10.1016/S0027-5107(02)00264-6

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PubMed publication ID

1 reference

PubMed publication ID

31 January 2017

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