(Q28578526)

31 January 2017

title

Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain (English)

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31 January 2017

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Yifan Lu

1

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31 January 2017

Tong Li

2

1 reference

31 January 2017

Hamid Y. Qureshi

3

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31 January 2017

Dong Han

4

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31 January 2017

Hemant K. Paudel

5

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31 January 2017

language of work or name

English

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publication date

10 June 2011

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Journal of Biological Chemistry

31 January 2017

published in

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31 January 2017

volume

286

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31 January 2017

issue

23

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31 January 2017

page(s)

20569–20581

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Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation

31 January 2017

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Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

29 September 2017

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Inducible packaging cells for large-scale production of lentiviral vectors in serum-free suspension culture

29 September 2017

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Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.

29 September 2017

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Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles

29 September 2017

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p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

29 September 2017

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Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism

29 September 2017

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29 September 2017

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The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin.

29 September 2017

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Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways

29 September 2017

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Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo

29 September 2017

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29 September 2017

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Curcumin, the active constituent of turmeric, inhibits amyloid peptide-induced cytochemokine gene expression and CCR5-mediated chemotaxis of THP-1 monocytes by modulating early growth response-1 transcription factor

29 September 2017

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29 September 2017

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Early growth response 1 protein, an upstream gatekeeper of the p53 tumor suppressor, controls replicative senescence

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Physical interaction between p53 and primary response gene Egr-1.

29 September 2017

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29 September 2017

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Are cerebrovascular factors involved in Alzheimer's disease?

29 September 2017

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Interaction of neuronal Cdc2-like protein kinase with microtubule-associated protein tau.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121503

Curcumin causes the growth arrest and apoptosis of B cell lymphoma by downregulation of egr-1, c-myc, bcl-XL, NF-kappa B, and p53.

29 September 2017

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Phosphorylation by neuronal cdc2-like protein kinase promotes dimerization of Tau protein in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121503

Egr transcription factors in the nervous system

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121503

Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.

29 September 2017

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Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121503

Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121503

Inhibitory phosphorylation of PP1alpha catalytic subunit during the G(1)/S transition

3 June 2018

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Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.

3 June 2018

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Changes of p53 in the brains of patients with Alzheimer's disease.

3 June 2018

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Proline-directed and non-proline-directed phosphorylation of PHF-tau.

3 June 2018

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Expression of Fos, Jun, and Krox family proteins in Alzheimer's disease.

3 June 2018

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Lack of pathology in a triple transgenic mouse model of Alzheimer's disease after overexpression of the anti-apoptotic protein Bcl-2.

21 January 2018

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TGF-beta1 promotes microglial amyloid-beta clearance and reduces plaque burden in transgenic mice.

21 January 2018

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Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

21 January 2018

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Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling.

21 January 2018

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EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells.

21 January 2018

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ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1.

21 January 2018

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Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain.

21 January 2018

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Caspase dependent DNA fragmentation might be associated with excitotoxicity in Alzheimer disease

21 January 2018

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Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT).

21 January 2018

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Familial FTDP-17 missense mutations inhibit microtubule assembly-promoting activity of tau by increasing phosphorylation at Ser202 in vitro

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111.220962

Glycogen synthase kinase-3beta is complexed with tau protein in brain microtubules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.220962

Cyclin-dependent protein kinase 5 primes microtubule-associated protein tau site-specifically for glycogen synthase kinase 3beta

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111.220962

Detection of phosphorylated Ser262 in fetal tau, adult tau, and paired helical filament tau.

21 January 2018

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Reconstitution of neuronal Cdc2-like kinase from bacteria-expressed Cdk5 and an active fragment of the brain-specific activator. Kinase activation in the absence of Cdk5 phosphorylation.

21 January 2018

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Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease.

21 January 2018

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Protein phosphatase 1 is targeted to microtubules by the microtubule-associated protein Tau.

21 January 2018

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Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies.

21 January 2018

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Does lithium therapy protect against the onset of dementia?

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M111.220962

Transforming growth factor-beta 1 is in plaques in Alzheimer and Down pathologies.

21 January 2018

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Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer's paired helical filaments.

27 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3121503

Immunohistochemical evidence for apoptosis in Alzheimer's disease.

27 November 2018

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Egr-1-induced endothelial gene expression: a common theme in vascular injury

27 November 2018

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12 December 2020

Inhibition of tissue factor gene activation in cultured endothelial cells by curcumin. Suppression of activation of transcription factors Egr-1, AP-1, and NF-kappa B

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12 December 2020

Suppression of human fibrosarcoma cell growth by transcription factor, Egr-1, involves down-regulation of Bcl-2

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12 December 2020

Curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor Egr-1

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12 December 2020

Suppression of transcription factor Egr-1 by curcumin

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12 December 2020