(Q28742454)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

title

PPAR-gamma agonist ameliorates kidney and liver disease in an orthologous rat model of human autosomal recessive polycystic kidney disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

autosomal recessive polycystic kidney

18 January 2020

main subject

0 references

1 reference

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

2

Hiroki Kurahashi

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

author name string

Daisuke Yoshihara

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Miwa Morita

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Masanori Kugita

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Yoshiyuki Hiki

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Tamio Yamaguchi

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

James P Calvet

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Darren P Wallace

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

Shizuko Nagao

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

language of work or name

English

0 references

publication date

8 December 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

American Journal of Physiology - Renal Physiology

18 January 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

volume

300

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

page(s)

F465-74

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

Autosomal dominant polycystic kidney disease: the last 3 years

18 January 2020

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Role of peroxisome proliferator-activated receptor-gamma (PPARgamma) during liver regeneration in rats

17 March 2017

1 reference

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Activation of the MEK5/ERK5 cascade is responsible for biliary dysgenesis in a rat model of Caroli's disease

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

The autosomal recessive polycystic kidney disease protein is localized to primary cilia, with concentration in the basal body area

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

The organization, promoter analysis, and expression of the human PPARgamma gene

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Rapamycin ameliorates PKD resulting from conditional inactivation of Pkd1.

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Effect of pioglitazone on survival and renal function in a mouse model of polycystic kidney disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

ERK1/2-dependent vascular endothelial growth factor signaling sustains cyst growth in polycystin-2 defective mice

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Effects of a PPAR-gamma agonist, on growth factor and insulin stimulated endothelial cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Cyst formation in kidney via B-Raf signaling in the PKD2 transgenic mice.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Autosomal recessive polycystic kidney disease and congenital hepatic fibrosis (ARPKD/CHF).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Thiazolidinediones as anti-cancer agents

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Cyst formation and activation of the extracellular regulated kinase pathway after kidney specific inactivation of Pkd1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Sirolimus reduces polycystic liver volume in ADPKD patients

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Fibrocystin/polyductin, found in the same protein complex with polycystin-2, regulates calcium responses in kidney epithelia.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Peroxisome proliferator-activated receptor-gamma and retinoic acid X receptor alpha represses the TGFbeta1 gene via PTEN-mediated p70 ribosomal S6 kinase-1 inhibition: role for Zf9 dephosphorylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Biliary dysgenesis in the PCK rat, an orthologous model of autosomal recessive polycystic kidney disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Lillian Jean Kaplan International Prize for advancement in the understanding of polycystic kidney disease. Understanding polycystic kidney disease: a systems biology approach

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Clinical profile of autosomal dominant polycystic liver disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Molecular basis of polycystic kidney disease: PKD1, PKD2 and PKHD1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Liver involvement in autosomal-dominant polycystic kidney disease: therapeutic dilemma.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Peroxisome proliferator-activated receptor gamma ligands inhibit retinoblastoma phosphorylation and G1--> S transition in vascular smooth muscle cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Renal accumulation and excretion of cyclic adenosine monophosphate in a murine model of slowly progressive polycystic kidney disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3044004

Rosiglitazone attenuates development of polycystic kidney disease and prolongs survival in Han:SPRD rats

3 June 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Activation of the AKT/mTOR pathway in autosomal recessive polycystic kidney disease (ARPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Late progression of renal pathology and cyst enlargement is reduced by rapamycin in a mouse model of nephronophthisis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Pioglitazone attenuates cardiac hypertrophy in rats with salt-sensitive hypertension: role of activation of AMP-activated protein kinase and inhibition of Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

PPAR-gamma agonist attenuates renal interstitial fibrosis and inflammation through reduction of TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Pioglitazone treatment enlarges subcutaneous adipocytes in insulin-resistant patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Pioglitazone improves the phenotype and molecular defects of a targeted Pkd1 mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Renal activation of extracellular signal-regulated kinase in rats with autosomal-dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Calcium channel inhibition accelerates polycystic kidney disease progression in the Cy/+ rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Inhibition of mTOR with sirolimus does not attenuate progression of liver and kidney disease in PCK rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Sirolimus and kidney growth in autosomal dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Effect of pioglitazone on the early stage of type 2 diabetic nephropathy in KK/Ta mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Rapamycin markedly slows disease progression in a rat model of polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Mitotic activation of Akt signalling pathway in Han:SPRD rats with polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Everolimus in patients with autosomal dominant polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

mTOR inhibitors in polycystic kidney disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist inhibits transforming growth factor-beta1 and matrix production in human dermal fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPRENAL.00460.2010

Increased water intake decreases progression of polycystic kidney disease in the PCK rat

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21147840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Secretion of cytokines and growth factors into autosomal dominant polycystic kidney disease liver cyst fluid

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21147840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Polycystic liver disease: new insights into disease pathogenesis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21147840

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1152/AJPRENAL.00460.2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21147840%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

1 reference