(Q28834608)

2

0 references

Joseph O Nwankwo

3

0 references

Richard T Arkwright

4

0 references

Boris Cvek

5

0 references

Jinbao Liu

6

0 references

Q Ping Dou

Expert Opinion on Therapeutic Patents

7

0 references

language of work or name

English

0 references

publication date

2015

0 references

published in

0 references

volume

25

0 references

issue

10

0 references

page(s)

1191-208

0 references

cites work

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A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistance

16 March 2017

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Modification by ubiquitin-like proteins: significance in apoptosis and autophagy pathways

16 March 2017

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Antiviral activity of a small molecule deubiquitinase inhibitor occurs via induction of the unfolded protein response

16 March 2017

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Crystal structure of the catalytic domain of UCHL5, a proteasome-associated human deubiquitinating enzyme, reveals an unproductive form of the enzyme

16 March 2017

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Mechanism, specificity and structure of the deubiquitinases

16 March 2017

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Breaking the chains: structure and function of the deubiquitinases

16 March 2017

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Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

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Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation

16 March 2017

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Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection

16 March 2017

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Ubiquitin-specific protease 14 expression in colorectal cancer is associated with liver and lymph node metastases

16 March 2017

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A genomic and functional inventory of deubiquitinating enzymes

16 March 2017

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A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14

16 March 2017

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Loss of PTEN facilitates HIF-1-mediated gene expression

16 March 2017

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Regulation of ubiquitin-dependent processes by deubiquitinating enzymes

16 March 2017

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Mechanism of the Antimicrobial Action of Pyrithione: Effects on Membrane Transport, ATP Levels, and Protein Synthesis

16 March 2017

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Recognition and processing of ubiquitin-protein conjugates by the proteasome

16 March 2017

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Ubiquitin-binding domains

7 April 2017

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DUBs, the regulation of cell identity and disease

7 April 2017

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Deubiquitinases and the new therapeutic opportunities offered to cancer

3 June 2018

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The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages

3 June 2018

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Deubiquitinase inhibition as a cancer therapeutic strategy

3 June 2018

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NMR spectroscopy-based metabolic profiling of drug-induced changes in vitro can discriminate between pharmacological classes

3 June 2018

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Overview of proteasome inhibitor-based anti-cancer therapies: perspective on bortezomib and second generation proteasome inhibitors versus future generation inhibitors of ubiquitin-proteasome system.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Deubiquitinating enzyme inhibitors and their potential in cancer therapy

3 June 2018

1 reference

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Ubiquitin pathways in neurodegenerative disease

3 June 2018

1 reference

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Mechanisms of generating polyubiquitin chains of different topology

3 June 2018

1 reference

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Clinically used antirheumatic agent auranofin is a proteasomal deubiquitinase inhibitor and inhibits tumor growth

3 June 2018

1 reference

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A novel proteasome inhibitor suppresses tumor growth via targeting both 19S proteasome deubiquitinases and 20S proteolytic peptidases

3 June 2018

1 reference

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The deubiquitinase A20 in immunopathology of autoimmune diseases

3 June 2018

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Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Proteasome inhibitors exert cytotoxicity and increase chemosensitivity via transcriptional repression of Notch1 in T-cell acute lymphoblastic leukemia

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Usp16 contributes to somatic stem-cell defects in Down's syndrome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Induction of tumor cell apoptosis by a proteasome deubiquitinase inhibitor is associated with oxidative stress

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

A novel crosstalk between two major protein degradation systems: regulation of proteasomal activity by autophagy.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

USP8 is a novel target for overcoming gefitinib resistance in lung cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Relationship between the proteasomal system and autophagy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

From bortezomib to other inhibitors of the proteasome and beyond

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Deubiquitinating enzymes as therapeutic targets in cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

UCHL1 S18Y variant is a risk factor for Parkinson's disease in Japan

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Proteasome deubiquitinases as novel targets for cancer therapy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

The hallmarks of cancer: a long non-coding RNA point of view.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

New targeted approaches against the ubiquitin-proteasome system in gastrointestinal malignancies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Regulation of KLF4 turnover reveals an unexpected tissue-specific role of pVHL in tumorigenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Toward understanding Machado-Joseph disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Metal complexes as inhibitors of the 26S proteasome in tumor cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Deubiquitinases in cancer: new functions and therapeutic options.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Intrinsic protein kinase activity in mitochondrial oxidative phosphorylation complexes.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Deubiquitinases in the regulation of NF-κB signaling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

The role of deubiquitinating enzymes in chromatin regulation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Isopeptidases in anticancer therapy: looking for inhibitors.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

The therapeutic potential of deubiquitinating enzyme inhibitors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

A new map to understand deubiquitination

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Ubiquitinated proteins activate the proteasome by binding to Usp14/Ubp6, which causes 20S gate opening

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Association between the ubiquitin carboxyl-terminal esterase L1 gene (UCHL1) S18Y variant and Parkinson's Disease: a HuGE review and meta-analysis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

The emerging complexity of protein ubiquitination

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

IFN-alpha and bortezomib overcome Bcl-2 and Mcl-1 overexpression in melanoma cells by stimulating the extrinsic pathway of apoptosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Ubiquitin and ubiquitin-like specific proteases targeted by infectious pathogens: Emerging patterns and molecular principles

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Ni(II), Cu(II), and Zn(II) diethyldithiocarbamate complexes show various activities against the proteasome in breast cancer cells.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

DUBs and disease: activity assays for inhibitor development.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Pyrrolidine dithiocarbamate-zinc(II) and -copper(II) complexes induce apoptosis in tumor cells by inhibiting the proteasomal activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Mechanisms, biology and inhibitors of deubiquitinating enzymes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Deubiquitinating enzymes as novel anticancer targets

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Clioquinol, a therapeutic agent for Alzheimer's disease, has proteasome-inhibitory, androgen receptor-suppressing, apoptosis-inducing, and antitumor activities in human prostate cancer cells and xenografts

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Riding the DUBway: regulation of protein trafficking by deubiquitylating enzymes.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from Bortezomib

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Proteasome inhibitor therapy in multiple myeloma

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Organic copper complexes as a new class of proteasome inhibitors and apoptosis inducers in human cancer cells

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Drug discovery in the ubiquitin regulatory pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Conjugation and deconjugation of ubiquitin regulating the destiny of proteins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Production of vascular endothelial growth factor by murine macrophages: regulation by hypoxia, lactate, and the inducible nitric oxide synthase pathway

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

In vivo disassembly of free polyubiquitin chains by yeast Ubp14 modulates rates of protein degradation by the proteasome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4834700

Chaperone-assisted assembly of the proteasome core particle

3 June 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1056737

Linear ubiquitin chains: NF-κB signalling, cell death and beyond.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1056737

Expression and clinical significance of UCH37 in human esophageal squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1056737

Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543776.2015.1056737

Evaluation of the in vivo antitumor activity and in vitro cytotoxic properties of auranofin, a coordinated gold compound, in murine tumor models

21 January 2018

1 reference

12 December 2020

The dissolution rate of zinc pyrithione

1 reference

12 December 2020

The ubiquitin proteasome system and its involvement in cell death pathways

1 reference

12 December 2020

Targeting the ubiquitin-proteasome system for cancer therapy

1 reference

12 December 2020

Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1

1 reference

12 December 2020

Correlation of the in vitro cytotoxic and in vivo antitumor activities of gold(I) coordination complexes

1 reference

12 December 2020

Ubiquitin and the control of protein fate in the secretory and endocytic pathways

1 reference

12 December 2020

10.1517/13543776.2015.1056737

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

26077642

1 reference