(Q35207883)

7 August 2017

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title

Drug discovery in the ubiquitin regulatory pathway (English)

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7 August 2017

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Brian R Wong

1

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7 August 2017

Francesco Parlati

2

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7 August 2017

Kunbin Qu

3

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7 August 2017

Susan Demo

4

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7 August 2017

Todd Pray

5

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7 August 2017

Jianing Huang

6

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7 August 2017

Donald G Payan

7

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7 August 2017

Mark K Bennett

8

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7 August 2017

publication date

1 August 2003

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7 August 2017

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7 August 2017

volume

8

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7 August 2017

issue

16

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7 August 2017

page(s)

746-754

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Mechanisms underlying ubiquitination

7 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Themes and variations on ubiquitylation

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Divergent N-terminal sequences target an inducible testis deubiquitinating enzyme to distinct subcellular structures

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

A ubiquitin mutant with specific defects in DNA repair and multiubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Receptor downregulation and multivesicular-body sorting

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

SCF and APC: the Yin and Yang of cell cycle regulated proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

The anaphase-promoting complex: proteolysis in mitosis and beyond

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Ubiquitin, E6-AP, and their role in p53 inactivation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Skp2 is oncogenic and overexpressed in human cancers

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Protein ISGylation modulates the JAK-STAT signaling pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

UBP43 (USP18) specifically removes ISG15 from conjugated proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Lipopolysaccharide activates the expression of ISG15-specific protease UBP43 via interferon regulatory factor 3.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Identification of ubiquitin ligases required for skeletal muscle atrophy

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

A highly conserved signal controls degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase in eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

PHD domains and E3 ubiquitin ligases: viruses make the connection

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Rare genetic mutations shed light on the pathogenesis of Parkinson disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

The ubiquitin pathway in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Case-control study of the ubiquitin carboxy-terminal hydrolase L1 gene in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Latest developments in crystallography and structure-based design of protein kinase inhibitors as drug candidates

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https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

A specific inhibitor of the ubiquitin activating enzyme: synthesis and characterization of adenosyl-phospho-ubiquitinol, a nonhydrolyzable ubiquitin adenylate analogue

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Panepophenanthrin, from a Mushroom Strain, a Novel Inhibitor of the Ubiquitin-Activating Enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Structure of a conjugating enzyme-ubiquitin thiolester intermediate reveals a novel role for the ubiquitin tail

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Pairs of dipeptides synergistically activate the binding of substrate by ubiquitin ligase through dissociation of its autoinhibitory domain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Efficient electrostatic solvation model for protein-fragment docking

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Isolation and structure elucidation of Chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Chalcone derivatives antagonize interactions between the human oncoprotein MDM2 and p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

The initial evaluation of non-peptidic small-molecule HDM2 inhibitors based on p53-HDM2 complex structure

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

A small molecule ubiquitination inhibitor blocks NF-kappa B-dependent cytokine expression in cells and rats

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Differentiation of Hdm2-mediated p53 ubiquitination and Hdm2 autoubiquitination activity by small molecular weight inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Structural basis for the specificity of ubiquitin C-terminal hydrolases

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Ulp1-SUMO crystal structure and genetic analysis reveal conserved interactions and a regulatory element essential for cell growth in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Thiol-dependent enzymes and their inhibitors: a review

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Cyclopentenone prostaglandins of the J series inhibit the ubiquitin isopeptidase activity of the proteasome pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Pharmacophore model for novel inhibitors of ubiquitin isopeptidases that induce p53-independent cell death

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Positive and negative regulation of APP amyloidogenesis by sumoylation.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

A mutant deubiquitinating enzyme (Ubp-M) associates with mitotic chromosomes and blocks cell division

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

The IAP family: endogenous caspase inhibitors with multiple biological activities

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

New tricks for ubiquitin and friends

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

Resistance is futile: assimilation of cellular machinery by HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2803%2902780-6

7 January 2021

10.1016/S1359-6446(03)02780-6

Identifiers

DOI

1 reference

7 August 2017

1 reference