(Q37945451)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

title

Deubiquitinases in cancer: new functions and therapeutic options (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Carlos López Otín

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

David Rodríguez

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

Jose M Freije

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

author name string

J M Fraile

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

language of work or name

English

0 references

publication date

26 September 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

volume

31

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

page(s)

2373-2388

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

issue

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1038/onc.2011.443

14 February 2020

exact match

0 references

cites work

CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The ubiquitous role of ubiquitin in the DNA damage response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Mechanism and function of deubiquitinating enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A screen for deubiquitinating enzymes involved in the G₂/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The role of deubiquitinating enzymes in chromatin regulation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Cytokine-regulated protein degradation by the ubiquitination system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Otubains: a new family of cysteine proteases in the ubiquitin pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitin-like protein conjugation and the ubiquitin-proteasome system as drug targets

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deciphering histone 2A deubiquitination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Endocytosis: the DUB version

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The therapeutic potential of deubiquitinating enzyme inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

K63-specific deubiquitination by two JAMM/MPN+ complexes: BRISC-associated Brcc36 and proteasomal Poh1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Proteasome inhibitors in cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Harnessing synthetic lethal interactions in anticancer drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitin-recognition protein Ufd1 couples the endoplasmic reticulum (ER) stress response to cell cycle control.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Polyubiquitin linkage profiles in three models of proteolytic stress suggest the etiology of Alzheimer disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Targeting ubiquitin specific proteases for drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Emerging principles in protease-based drug discovery

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Usp18 regulates epidermal growth factor (EGF) receptor expression and cancer cell survival via microRNA-7.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

FAM/USP9x, a deubiquitinating enzyme essential for TGFbeta signaling, controls Smad4 monoubiquitination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

An emerging model for BAP1's role in regulating cell cycle progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Hydrogen peroxide prolongs nuclear localization of NF-kappaB in activated cells by suppressing negative regulatory mechanisms.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP4 targets TAK1 to downregulate TNFα-induced NF-κB activation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The human UNP locus at 3p21.31 encodes two tissue-selective, cytoplasmic isoforms with deubiquitinating activity that have reduced expression in small cell lung carcinoma cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Protease addiction and synthetic lethality in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

CYLD regulates angiogenesis by mediating vascular endothelial cell migration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Histone deacetylase inhibition attenuates diabetes-associated kidney growth: potential role for epigenetic modification of the epidermal growth factor receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Death-from-cancer signatures and stem cell contribution to metastatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The isopeptidase USP2a regulates the stability of fatty acid synthase in prostate cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Patented small molecule inhibitors in the ubiquitin proteasome system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP1 deubiquitinase maintains phosphorylated CHK1 by limiting its DDB1-dependent degradation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Complementary roles for Rpn11 and Ubp6 in deubiquitination and proteolysis by the proteasome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinating enzymes are IN/(trinsic to proteasome function).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Frequent mutation of BAP1 in metastasizing uveal melanomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinases in the regulation of NF-κB signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The p53 pathway: positive and negative feedback loops

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Integrating genetic approaches into the discovery of anticancer drugs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Reduced expression of CYLD in human colon and hepatocellular carcinomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Identification of novel chemical inhibitors for ubiquitin C-terminal hydrolase-L3 by virtual screening

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Structure and mechanisms of the proteasome-associated deubiquitinating enzyme USP14

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The COP9 signalosome mediates beta-catenin degradation by deneddylation and blocks adenomatous polyposis coli destruction via USP15.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A20: from ubiquitin editing to tumour suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Cloning of a novel signaling molecule, AMSH-2, that potentiates transforming growth factor beta signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

UCH-L1 promotes cancer metastasis in prostate cancer cells through EMT induction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Analysis of cis-acting sequences and trans-acting factors regulating the interleukin-3 response element of the DUB-1 gene

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Gene mapping and expression analysis of 16q loss of heterozygosity identifies WWOX and CYLD as being important in determining clinical outcome in multiple myeloma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Regulation of cell cycle progression and gene expression by H2A deubiquitination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The concept of synthetic lethality in the context of anticancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinase inhibition by small-molecule WP1130 triggers aggresome formation and tumor cell apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

PTMs in conversation: activity and function of deubiquitinating enzymes regulated via post-translational modifications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinating enzyme USP36 contains the PEST motif and is polyubiquitinated

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Wnt signalling and its impact on development and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Breaking the chains: structure and function of the deubiquitinases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The structure of the CYLD USP domain explains its specificity for Lys63-linked polyubiquitin and reveals a B box module

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Inactivation of HAUSP in vivo modulates p53 function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

GLI1-dependent transcriptional repression of CYLD in basal cell carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated, polyneddylated, and dimerized

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1alpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-kappaB signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Regulation of ErbB2 receptor status by the proteasomal DUB POH1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

JTV1 co-activates FBP to induce USP29 transcription and stabilize p53 in response to oxidative stress

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Proteases: multifunctional enzymes in life and disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The regulatory crosstalk between kinases and proteases in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Protease degradomics: a new challenge for proteomics

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Mechanisms, biology and inhibitors of deubiquitinating enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Identification of distinctive patterns of USP19-mediated growth regulation in normal and malignant cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

An atlas of altered expression of deubiquitinating enzymes in human cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A novel superfamily of predicted cysteine proteases from eukaryotes, viruses and Chlamydia pneumoniae

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinating function of ataxin-3: insights from the solution structure of the Josephin domain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Proteolytic networks in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Down-regulation of CYLD expression by Snail promotes tumor progression in malignant melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ataxin-3 is subject to autolytic cleavage.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

AMSH is an endosome-associated ubiquitin isopeptidase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

DJ-1 enhances cell survival through the binding of Cezanne, a negative regulator of NF-kappaB

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Reversible monoubiquitination regulates the Parkinson disease-associated ubiquitin hydrolase UCH-L1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

An RNAi screen identifies USP2 as a factor required for TNF-α-induced NF-κB signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Derailed endocytosis: an emerging feature of cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Pharmacophore model for novel inhibitors of ubiquitin isopeptidases that induce p53-independent cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The USP1/UAF1 complex promotes double-strand break repair through homologous recombination

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Regulation of mitochondrial morphology by USP30, a deubiquitinating enzyme present in the mitochondrial outer membrane

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The 26 S proteasome: from basic mechanisms to drug targeting

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Control of AIF-mediated cell death by antagonistic functions of CHIP ubiquitin E3 ligase and USP2 deubiquitinating enzyme

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The ubiquitin-specific protease USP28 is required for MYC stability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

NF-kappaB and cancer: how intimate is this relationship

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The isopeptidase USP2a protects human prostate cancer from apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A genomic analysis of rat proteases and protease inhibitors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Human and mouse proteases: a comparative genomic approach

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The Degradome database: mammalian proteases and diseases of proteolysis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Dysregulated TRK signalling is a therapeutic target in CYLD defective tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The role of deubiquitinating enzymes in apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Synthetic lethal approaches to breast cancer therapy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Negative regulation of JNK signaling by the tumor suppressor CYLD.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

CYLD mutations in familial skin appendage tumours

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

BRCA2 is ubiquitinated in vivo and interacts with USP11, a deubiquitinating enzyme that exhibits prosurvival function in the cellular response to DNA damage

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

CSN controls NF-kappaB by deubiquitinylation of IkappaBalpha

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Suppression of cancer cell growth by promoting cyclin D1 degradation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Non-oncogene addiction and the stress phenotype of cancer cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Defining the human deubiquitinating enzyme interaction landscape

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The tumor suppressor CYLD regulates entry into mitosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Characterization of selective ubiquitin and ubiquitin-like protease inhibitors using a fluorescence-based multiplex assay format

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Trabid, a new positive regulator of Wnt-induced transcription with preference for binding and cleaving K63-linked ubiquitin chains

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Targeting proteases: successes, failures and future prospects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Protein partners of deubiquitinating enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Cancer genes and the pathways they control

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Regulation of ubiquitin-dependent processes by deubiquitinating enzymes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP15 plays an essential role for caspase-3 activation during Paclitaxel-induced apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin-remodeling complex

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

CSN5/Jab1 controls multiple events in the mammalian cell cycle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for toll-like receptor 2 signaling via negative cross-talk with TRAF6 AND TRAF7.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Epigenetic identification of ubiquitin carboxyl-terminal hydrolase L1 as a functional tumor suppressor and biomarker for hepatocellular carcinoma and other digestive tumors.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP10 regulates p53 localization and stability by deubiquitinating p53

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Synergistic antitumor activity of gemcitabine and ABT-737 in vitro and in vivo through disrupting the interaction of USP9X and Mcl-1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

The putative cancer stem cell marker USP22 is a subunit of the human SAGA complex required for activated transcription and cell-cycle progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

Transcriptional regulation by histone ubiquitination and deubiquitination.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

A histone H2A deubiquitinase complex coordinating histone acetylation and H1 dissociation in transcriptional regulation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

High incidence of ubiquitin-like domains in human ubiquitin-specific proteases

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2011.443

31 March 2020

Identifiers

DOI

10.1038/ONC.2011.443

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21996736%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference