(Q37714303)

22 August 2017

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title

The regulatory crosstalk between kinases and proteases in cancer (English)

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22 August 2017

1

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22 August 2017

Tony Hunter

2

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PubMed ID

20300104

22 August 2017

language of work or name

English

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publication date

19 March 2010

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22 August 2017

Nature Reviews Cancer

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22 August 2017

10

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22 August 2017

278-292

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22 August 2017

4

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https://scigraph.springernature.com/pub.10.1038/nrc2823

22 August 2017

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cites work

Oncogenic kinase signalling

1 reference

Proteases: multifunctional enzymes in life and disease

31 March 2020

1 reference

The protein kinase complement of the human genome

31 March 2020

1 reference

Human and mouse proteases: a comparative genomic approach

31 March 2020

1 reference

The Degradome database: mammalian proteases and diseases of proteolysis

31 March 2020

1 reference

The ADAMs: signalling scissors in the tumour microenvironment

31 March 2020

1 reference

31 March 2020

1 reference

Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.

31 March 2020

1 reference

Src kinase phosphorylates Caspase-8 on Tyr380: a novel mechanism of apoptosis suppression

31 March 2020

1 reference

Mutual inhibition of separase and Cdk1 by two-step complex formation

31 March 2020

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Caspases and kinases in a death grip

31 March 2020

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Direct cleavage of ROCK II by granzyme B induces target cell membrane blebbing in a caspase-independent manner.

31 March 2020

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Apoptosis: controlled demolition at the cellular level

31 March 2020

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ADAMs: key components in EGFR signalling and development

31 March 2020

1 reference

Presenilin: running with scissors in the membrane

31 March 2020

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How proteolysis drives the cell cycle

31 March 2020

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Proteolysis: from the lysosome to ubiquitin and the proteasome

31 March 2020

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Degradation of activated protein kinases by ubiquitination

31 March 2020

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Derailed endocytosis: an emerging feature of cancer

31 March 2020

1 reference

A quantitative atlas of mitotic phosphorylation

31 March 2020

1 reference

The COP9 signalosome: more than a protease

31 March 2020

1 reference

The Jab1/COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression.

31 March 2020

1 reference

The emerging role of the COP9 signalosome in cancer

31 March 2020

1 reference

CSN5 isopeptidase activity links COP9 signalosome activation to breast cancer progression

31 March 2020

1 reference

Breaking the chains: structure and function of the deubiquitinases

31 March 2020

1 reference

Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo

31 March 2020

1 reference

UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation

31 March 2020

1 reference

An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme

31 March 2020

1 reference

AMSH is an endosome-associated ubiquitin isopeptidase

31 March 2020

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RNA interference screen identifies Usp18 as a regulator of epidermal growth factor receptor synthesis

31 March 2020

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Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

31 March 2020

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A role for the deubiquitinating enzyme USP28 in control of the DNA-damage response

31 March 2020

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The deubiquitinating enzyme USP11 controls an IkappaB kinase alpha (IKKalpha)-p53 signaling pathway in response to tumor necrosis factor alpha (TNFalpha)

31 March 2020

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Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B.

31 March 2020

1 reference

CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes

31 March 2020

1 reference

The tumor suppressor CYLD regulates entry into mitosis

31 March 2020

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Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization

31 March 2020

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Regulation of cell cycle progression and gene expression by H2A deubiquitination

31 March 2020

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Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities

31 March 2020

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

31 March 2020

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A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.

31 March 2020

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IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway

31 March 2020

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Phosphorylation of the tumor suppressor CYLD by the breast cancer oncogene IKKepsilon promotes cell transformation

31 March 2020

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Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation

31 March 2020

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14-3-3-dependent inhibition of the deubiquitinating activity of UBPY and its cancellation in the M phase.

31 March 2020

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Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1

31 March 2020

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Global, in vivo, and site-specific phosphorylation dynamics in signaling networks

31 March 2020

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Phospho.ELM: a database of phosphorylation sites--update 2008.

31 March 2020

1 reference

PHOSIDA (phosphorylation site database): management, structural and evolutionary investigation, and prediction of phosphosites

31 March 2020

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Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner

31 March 2020

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Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis

31 March 2020

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Dual inhibition of sister chromatid separation at metaphase.

31 March 2020

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Overexpression of Separase induces aneuploidy and mammary tumorigenesis

31 March 2020

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Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers

31 March 2020

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Caspase-dependent cleavage of c-Abl contributes to apoptosis

31 March 2020

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Cleavage-mediated activation of Chk1 during apoptosis

31 March 2020

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Unique and overlapping substrate specificities of caspase-8 and caspase-10.

31 March 2020

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Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

31 March 2020

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Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

31 March 2020

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Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase

31 March 2020

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Sustained JNK signaling by proteolytically processed HPK1 mediates IL-3 independent survival during monocytic differentiation.

31 March 2020

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Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes

31 March 2020

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p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB

31 March 2020

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Cleavage of focal adhesion kinase by caspases during apoptosis

31 March 2020

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Caspases-dependent cleavage of mitotic checkpoint proteins in response to microtubule inhibitor.

31 March 2020

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Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis.

31 March 2020

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Differential requirements for caspase-8 activity in the mechanism of phosphorylation of eIF2alpha, cleavage of eIF4GI and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells

31 March 2020

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Cleavage and inactivation of ATM during apoptosis.

31 March 2020

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DNA-dependent protein kinase is a target for a CPP32-like apoptotic protease

31 March 2020

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Proteolytic cleavages give receptor tyrosine kinases the gift of ubiquity.

31 March 2020

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Caspase cleavage of HER-2 releases a Bad-like cell death effector

31 March 2020

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Regulation of cell death protease caspase-9 by phosphorylation

31 March 2020

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Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK.

31 March 2020

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The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development

31 March 2020

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p38alpha- and DYRK1A-dependent phosphorylation of caspase-9 at an inhibitory site in response to hyperosmotic stress

31 March 2020

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Phosphorylation of murine caspase-9 by the protein kinase casein kinase 2 regulates its cleavage by caspase-8.

31 March 2020

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Protein kinase A regulates caspase-9 activation by Apaf-1 downstream of cytochrome c.

31 March 2020

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Phosphorylation of caspase-9 by CDK1/cyclin B1 protects mitotic cells against apoptosis

31 March 2020

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Caspase-8 interacts with the p85 subunit of phosphatidylinositol 3-kinase to regulate cell adhesion and motility

31 March 2020

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Dynamic regulation of neutrophil survival through tyrosine phosphorylation or dephosphorylation of caspase-8

31 March 2020

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p38-MAPK signals survival by phosphorylation of caspase-8 and caspase-3 in human neutrophils

31 March 2020

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Identification of CARDIAK, a RIP-like kinase that associates with caspase-1

31 March 2020

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Regulation of monocyte apoptosis by the protein kinase Cdelta-dependent phosphorylation of caspase-3.

31 March 2020

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c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage

31 March 2020

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DNA-PKcs-PIDDosome: a nuclear caspase-2-activating complex with role in G2/M checkpoint maintenance

31 March 2020

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Cleavage of focal adhesion kinase by different proteases during SRC-regulated transformation and apoptosis. Distinct roles for calpain and caspases.

31 March 2020

1 reference

Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis

31 March 2020

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Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosis

31 March 2020

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Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide.

31 March 2020

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RETRACTED: Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212

31 March 2020

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Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis

31 March 2020

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Suppression of cancer cell migration and invasion by protein phosphatase 2A through dephosphorylation of mu- and m-calpains

31 March 2020

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ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis

31 March 2020

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Identification of a critical tyrosine residue in caspase 8 that promotes cell migration

31 March 2020

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Critical role for caspase-8 in epidermal growth factor signaling

31 March 2020

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Regulating cell migration: calpains make the cut.

31 March 2020

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Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion

31 March 2020

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Neuronal nitric oxide synthase and calmodulin-dependent protein kinase IIalpha undergo neurotoxin-induced proteolysis.

31 March 2020

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N-terminal cleavage of GSK-3 by calpain: a new form of GSK-3 regulation.

31 March 2020

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Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation

31 March 2020

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Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains

31 March 2020

1 reference

Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain

31 March 2020

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Capn4 overexpression underlies tumor invasion and metastasis after liver transplantation for hepatocellular carcinoma

31 March 2020

1 reference

Cyclin E both regulates and is regulated by calpain 2, a protease associated with metastatic breast cancer phenotype

31 March 2020

1 reference

Furin at the cutting edge: from protein traffic to embryogenesis and disease

31 March 2020

1 reference

Selective inhibition of proprotein convertases represses the metastatic potential of human colorectal tumor cells

31 March 2020

1 reference

Intramembrane proteolysis by gamma-secretase

31 March 2020

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gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase

31 March 2020

1 reference

The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells

31 March 2020

1 reference

The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis.

31 March 2020

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Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase.

31 March 2020

1 reference

Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.

31 March 2020

1 reference

Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion

31 March 2020

1 reference

Pharmacoproteomics of a metalloproteinase hydroxamate inhibitor in breast cancer cells: dynamics of membrane type 1 matrix metalloproteinase-mediated membrane protein shedding

31 March 2020

1 reference

MT-SP1 proteolysis and regulation of cell-microenvironment interactions

31 March 2020

1 reference

The epidermal growth factor receptor (EGFR) is proteolytically modified by the Matriptase-Prostasin serine protease cascade in cultured epithelial cells

31 March 2020

1 reference

A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.

31 March 2020

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Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10

31 March 2020

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ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity

31 March 2020

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Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases

31 March 2020

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Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer

31 March 2020

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Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding.

31 March 2020

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Regulation of matrix metalloproteinase-2 (MMP-2) activity by phosphorylation

31 March 2020

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Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and tumor cell migration

31 March 2020

1 reference

Epidermal growth factor receptor-mediated membrane type 1 matrix metalloproteinase endocytosis regulates the transition between invasive versus expansive growth of ovarian carcinoma cells in three-dimensional collagen

31 March 2020

1 reference

GSK3beta activity modifies the localization and function of presenilin 1.

31 March 2020

1 reference

A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling

31 March 2020

1 reference

Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin

31 March 2020

1 reference

Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis

31 March 2020

1 reference

Phosphorylation of presenilin 1 at the caspase recognition site regulates its proteolytic processing and the progression of apoptosis

31 March 2020

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Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis

31 March 2020

1 reference

VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling.

31 March 2020

1 reference

Novel anticancer targets: revisiting ERBB2 and discovering ERBB3.

31 March 2020

1 reference

Targeting cancer with small molecule kinase inhibitors

31 March 2020

1 reference

Proteasome inhibitors in cancer therapy: lessons from the first decade

31 March 2020

1 reference

Strategies for MMP inhibition in cancer: innovations for the post-trial era.

31 March 2020

1 reference

The emerging roles of human tissue kallikreins in cancer

31 March 2020

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Cysteine cathepsin proteases as pharmacological targets in cancer

31 March 2020

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Emerging roles of proteases in tumour suppression

31 March 2020

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Expression of p95HER2, a truncated form of the HER2 receptor, and response to anti-HER2 therapies in breast cancer.

31 March 2020

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Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer

31 March 2020

1 reference

Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor

31 March 2020

1 reference

TACE/ADAM-17: a component of the epidermal growth factor receptor axis and a promising therapeutic target in colorectal cancer

31 March 2020

1 reference

ADAM9 is involved in pathological retinal neovascularization

31 March 2020

1 reference

DUBs and cancer: the role of deubiquitinating enzymes as oncogenes, non-oncogenes and tumor suppressors

31 March 2020

1 reference

Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib.

31 March 2020

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Bortezomib inhibits cell-cell adhesion and cell migration and enhances epidermal growth factor receptor inhibitor-induced cell death in squamous cell cancer

31 March 2020

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Synergistic anti-proliferative and pro-apoptotic activity of combined therapy with bortezomib, a proteasome inhibitor, with anti-epidermal growth factor receptor (EGFR) drugs in human cancer cells

31 March 2020

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Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated Akt.

31 March 2020

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Down-regulation of phospho-Akt is a major molecular determinant of bortezomib-induced apoptosis in hepatocellular carcinoma cells

31 March 2020

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Proteasome inhibition activates epidermal growth factor receptor (EGFR) and EGFR-independent mitogenic kinase signaling pathways in pancreatic cancer cells

31 March 2020

1 reference

Inhibition of p38alpha MAPK enhances proteasome inhibitor-induced apoptosis of myeloma cells by modulating Hsp27, Bcl-X(L), Mcl-1 and p53 levels in vitro and inhibits tumor growth in vivo

31 March 2020

1 reference

ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor

31 March 2020

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

31 March 2020

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Targeting inhibitor of apoptosis proteins in combination with ErbB antagonists in breast cancer

31 March 2020

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Resistance of human glioblastoma multiforme cells to growth factor inhibitors is overcome by blockade of inhibitor of apoptosis proteins

31 March 2020

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Kinomics: methods for deciphering the kinome

31 March 2020

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In search of partners: linking extracellular proteases to substrates

31 March 2020

1 reference

Protease degradomics: a new challenge for proteomics

31 March 2020

1 reference

Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPK and its substrate caspase 3.

31 March 2020

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Identification of PP1alpha as a caspase-9 regulator in IL-2 deprivation-induced apoptosis

31 March 2020

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A caspase-dependent cleavage of CDC25A generates an active fragment activating cyclin-dependent kinase 2 during apoptosis.

31 March 2020

1 reference

Phosphorylation-regulated cleavage of the tumor suppressor PTEN by caspase-3: implications for the control of protein stability and PTEN-protein interactions

31 March 2020

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Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B

31 March 2020

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Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity

31 March 2020

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Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration

31 March 2020

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Downregulation of PP2A(Cdc55) phosphatase by separase initiates mitotic exit in budding yeast.

31 March 2020

1 reference

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

31 March 2020

1 reference

The ubiquitin specific protease 4 (USP4) is a new player in the Wnt signalling pathway

31 March 2020

1 reference

12 December 2020

NH2-terminally truncated HER-2/neu protein: relationship with shedding of the extracellular domain and with prognostic factors in breast cancer

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12 December 2020

Conversion of phosphorylase b to phosphorylase a in muscle extracts

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12 December 2020

Limited proteolysis of protein kinase C subspecies by calcium-dependent neutral protease (calpain)

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12 December 2020

Metabolic control of proteasome function

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12 December 2020

Identifiers

DOI

10.1038/NRC2823

1 reference

22 August 2017

1 reference

PubMed ID

20300104