(Q36735417)

16 August 2017

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title

In search of partners: linking extracellular proteases to substrates (English)

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16 August 2017

1

Christopher M Overall

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16 August 2017

Carl P Blobel

2

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16 August 2017

publication date

14 February 2007

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Nature Reviews Molecular Cell Biology

16 August 2017

published in

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16 August 2017

volume

8

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16 August 2017

issue

3

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16 August 2017

page(s)

245-257

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https://scigraph.springernature.com/pub.10.1038/nrm2120

16 August 2017

exact match

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31 March 2020

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Ectodomain shedding of TGF-alpha and other transmembrane proteins is induced by receptor tyrosine kinase activation and MAP kinase signaling cascades

31 March 2020

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A proteomic approach to identify substrates of matrix metalloproteinase-14 in human plasma.

31 March 2020

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Identification of caspase-3 degradome by two-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization-time of flight analysis

31 March 2020

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31 March 2020

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31 March 2020

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Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis

31 March 2020

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31 March 2020

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A proteomic approach to characterize protein shedding

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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New functions for the matrix metalloproteinases in cancer progression

31 March 2020

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31 March 2020

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Cathepsin cysteine proteases are effectors of invasive growth and angiogenesis during multistage tumorigenesis

31 March 2020

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MMP-7 promotes prostate cancer-induced osteolysis via the solubilization of RANKL.

31 March 2020

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Control of peripheral nerve myelination by the beta-secretase BACE1

31 March 2020

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Analysis of host- and tumor-derived proteinases using a custom dual species microarray reveals a protective role for stromal matrix metalloproteinase-12 in non-small cell lung cancer

31 March 2020

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ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression.

31 March 2020

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Potential role for ADAM15 in pathological neovascularization in mice

31 March 2020

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31 March 2020

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

31 March 2020

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

31 March 2020

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Mice with defects in HB-EGF ectodomain shedding show severe developmental abnormalities.

31 March 2020

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Membrane-bound TNF supports secondary lymphoid organ structure but is subservient to secreted TNF in driving autoimmune inflammation.

31 March 2020

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BMP1 controls TGFbeta1 activation via cleavage of latent TGFbeta-binding protein

31 March 2020

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A point mutation in the juxtamembrane stalk of human angiotensin I-converting enzyme invokes the action of a distinct secretase

31 March 2020

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Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling

31 March 2020

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Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin

31 March 2020

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De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent

31 March 2020

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Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

31 March 2020

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Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase

31 March 2020

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Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand

31 March 2020

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The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis

31 March 2020

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Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

31 March 2020

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Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury.

31 March 2020

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

31 March 2020

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

31 March 2020

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Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

31 March 2020

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ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

31 March 2020

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Human and mouse proteases: a comparative genomic approach

31 March 2020

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Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes.

31 March 2020

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The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

31 March 2020

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Specific sequence elements are required for the expression of functional tumor necrosis factor-alpha-converting enzyme (TACE).

31 March 2020

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X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design

31 March 2020

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Inhibitory antibodies against endopeptidase activity of human adamalysin 19

31 March 2020

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Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha

31 March 2020

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Role of TIMPs (tissue inhibitors of metalloproteinases) in pericellular proteolysis: the specificity is in the detail

31 March 2020

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Inhibition of the tumor necrosis factor-alpha-converting enzyme by its pro domain

31 March 2020

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Aptamers as tools for target validation

31 March 2020

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Gene discovery by ribozyme and siRNA libraries

31 March 2020

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Dilating the degradome: matrix metalloproteinase 2 (MMP-2) cuts to the heart of the matter

31 March 2020

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inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRM2120

1 reference

16 August 2017

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