(Q37893455)

24 August 2017

1 reference

title

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death (English)

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24 August 2017

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Domagoj Vucic

1

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PubMed ID

21697901

24 August 2017

Vishva M Dixit

series ordinal

2

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PubMed ID

21697901

24 August 2017

Ingrid E Wertz

series ordinal

3

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24 August 2017

23 June 2011

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Nature Reviews Molecular Cell Biology

24 August 2017

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24 August 2017

12

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24 August 2017

439-452

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24 August 2017

7

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https://scigraph.springernature.com/pub.10.1038/nrm3143

24 August 2017

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cites work

RING domain E3 ubiquitin ligases

1 reference

Mechanisms underlying ubiquitination

31 March 2020

1 reference

SCF and Cullin/Ring H2-based ubiquitin ligases

31 March 2020

1 reference

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

31 March 2020

1 reference

Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation

31 March 2020

1 reference

Catalysis of lysine 48-specific ubiquitin chain assembly by residues in E2 and ubiquitin.

31 March 2020

1 reference

The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2

31 March 2020

1 reference

Role of ubiquitin- and Ubl-binding proteins in cell signaling

31 March 2020

1 reference

Ubiquitin as a central cellular regulator.

31 March 2020

1 reference

Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies

31 March 2020

1 reference

Alterations in the apoptotic machinery and their potential role in anticancer drug resistance

31 March 2020

1 reference

The BCL-2 protein family: opposing activities that mediate cell death

31 March 2020

1 reference

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

31 March 2020

1 reference

Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

31 March 2020

1 reference

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

31 March 2020

1 reference

The apoptosome: signalling platform of cell death

31 March 2020

1 reference

Death receptors: signaling and modulation

31 March 2020

1 reference

Life and death by death receptors

31 March 2020

1 reference

The many roles of FAS receptor signaling in the immune system

31 March 2020

1 reference

Inhibition of fas death signals by FLIPs

31 March 2020

1 reference

IAP proteins: blocking the road to death's door

31 March 2020

1 reference

Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

31 March 2020

1 reference

Blinded by the Light: The Growing Complexity of p53

31 March 2020

1 reference

RIP kinases at the crossroads of cell death and survival

31 March 2020

1 reference

Regulation of death receptor signaling by the ubiquitin system

31 March 2020

1 reference

Regulation of apoptosis proteins in cancer cells by ubiquitin

31 March 2020

1 reference

Regulation of apoptosis in Drosophila

31 March 2020

1 reference

Drosophila IAP antagonists form multimeric complexes to promote cell death

31 March 2020

1 reference

Temporal regulation of Drosophila IAP1 determines caspase functions in sensory organ development.

31 March 2020

1 reference

Systematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligases

31 March 2020

1 reference

Inactivation of effector caspases through nondegradative polyubiquitylation

31 March 2020

1 reference

A novel F-box protein is required for caspase activation during cellular remodeling in Drosophila

31 March 2020

1 reference

Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family

31 March 2020

1 reference

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

31 March 2020

1 reference

Regulation of apoptosis by XIAP ubiquitin-ligase activity

31 March 2020

1 reference

The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing

31 March 2020

1 reference

Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO

31 March 2020

1 reference

Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro

31 March 2020

1 reference

Posttranscriptional downregulation of c-IAP2 by the ubiquitin protein ligase c-IAP1 in vivo

31 March 2020

1 reference

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

31 March 2020

1 reference

X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility

31 March 2020

1 reference

c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1.

31 March 2020

1 reference

TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2

31 March 2020

1 reference

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

31 March 2020

1 reference

The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

31 March 2020

1 reference

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

31 March 2020

1 reference

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

31 March 2020

1 reference

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

31 March 2020

1 reference

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

31 March 2020

1 reference

What Determines the Specificity and Outcomes of Ubiquitin Signaling?

31 March 2020

1 reference

Linear ubiquitination prevents inflammation and regulates immune signalling

31 March 2020

1 reference

A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta.

31 March 2020

1 reference

Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction

31 March 2020

1 reference

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

31 March 2020

1 reference

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

31 March 2020

1 reference

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

31 March 2020

1 reference

Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling

31 March 2020

1 reference

IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

31 March 2020

1 reference

IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

31 March 2020

1 reference

Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK.

31 March 2020

1 reference

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha.

31 March 2020

1 reference

The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development

31 March 2020

1 reference

(Un)expected roles of c-IAPs in apoptotic and NFkappaB signaling pathways

31 March 2020

1 reference

Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

31 March 2020

1 reference

Deletion of cIAP1 and cIAP2 in murine B lymphocytes constitutively activates cell survival pathways and inactivates the germinal center response

31 March 2020

1 reference

Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis

31 March 2020

1 reference

Molecular mechanisms of necroptosis: an ordered cellular explosion

31 March 2020

1 reference

Non-canonical NF-κB activation and abnormal B cell accumulation in mice expressing ubiquitin protein ligase-inactive c-IAP2.

31 March 2020

1 reference

Tumor suppressive functions of p53

31 March 2020

1 reference

Making sense of ubiquitin ligases that regulate p53.

31 March 2020

1 reference

31 March 2020

1 reference

The p53 orchestra: Mdm2 and Mdmx set the tone

31 March 2020

1 reference

Regulation of FOXO protein stability via ubiquitination and proteasome degradation

31 March 2020

1 reference

Mdm2-mediated ubiquitylation: p53 and beyond.

31 March 2020

1 reference

MDM2 regulates dihydrofolate reductase activity through monoubiquitination

31 March 2020

1 reference

Ribosomal protein S7 is both a regulator and a substrate of MDM2

31 March 2020

1 reference

Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation

31 March 2020

1 reference

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

31 March 2020

1 reference

p53 ubiquitination: Mdm2 and beyond

31 March 2020

1 reference

The ubiquitin-protein ligase Itch regulates p73 stability

31 March 2020

1 reference

Degradation of p63 by Itch.

31 March 2020

1 reference

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

31 March 2020

1 reference

Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.

31 March 2020

1 reference

ARTS and Siah collaborate in a pathway for XIAP degradation

31 March 2020

1 reference

The mitochondrial ARTS protein promotes apoptosis through targeting XIAP

31 March 2020

1 reference

Siah: new players in the cellular response to hypoxia.

31 March 2020

1 reference

Proline hydroxylation and gene expression

31 March 2020

1 reference

SnapShot: F Box Proteins II

31 March 2020

1 reference

Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer

31 March 2020

1 reference

Can't live without them, can live with them: roles of caspases during vital cellular processes

31 March 2020

1 reference

SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box

31 March 2020

1 reference

Control of meiotic and mitotic progression by the F box protein beta-Trcp1 in vivo

31 March 2020

1 reference

Impaired degradation of inhibitory subunit of NF-kappa B (I kappa B) and beta-catenin as a result of targeted disruption of the beta-TrCP1 gene

31 March 2020

1 reference

Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage

31 March 2020

1 reference

betaTrCP- and Rsk1/2-mediated degradation of BimEL inhibits apoptosis

31 March 2020

1 reference

SAG/ROC-SCF beta-TrCP E3 ubiquitin ligase promotes pro-caspase-3 degradation as a mechanism of apoptosis protection

31 March 2020

1 reference

SCF TrCP1 activates and ubiquitylates TAp63gamma

31 March 2020

1 reference

Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.

31 March 2020

1 reference

ERK and the F-box protein betaTRCP target STAT1 for degradation

31 March 2020

1 reference

S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

31 March 2020

1 reference

Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization

31 March 2020

1 reference

Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases

31 March 2020

1 reference

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

31 March 2020

1 reference

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

31 March 2020

1 reference

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.

31 March 2020

1 reference

The ubiquitous nature of cancer: the role of the SCF(Fbw7) complex in development and transformation

31 March 2020

1 reference

The Notch signaling pathway: molecular basis of cell context dependency

31 March 2020

1 reference

A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy

31 March 2020

1 reference

The Drosophila F box protein archipelago regulates dMyc protein levels in vivo

31 March 2020

1 reference

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

31 March 2020

1 reference

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

31 March 2020

1 reference

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

31 March 2020

1 reference

31 March 2020

A convoluted way to die.

1 reference

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

31 March 2020

1 reference

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7.

31 March 2020

1 reference

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

31 March 2020

1 reference

Phosphorylation of Mcl-1 by CDK1-cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest.

31 March 2020

1 reference

Signaling to NF-kappaB: regulation by ubiquitination

31 March 2020

1 reference

IAPs, RINGs and ubiquitylation

31 March 2020

1 reference

Ubiquitin binding to A20 ZnF4 is required for modulation of NF-κB signaling

31 March 2020

1 reference

A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions

31 March 2020

1 reference

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

31 March 2020

1 reference

A20: from ubiquitin editing to tumour suppression

31 March 2020

1 reference

Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice

31 March 2020

1 reference

Expression, biological activities and mechanisms of action of A20 (TNFAIP3).

31 March 2020

1 reference

Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase

31 March 2020

1 reference

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor-induced toxicity and experimental colitis

31 March 2020

1 reference

Ubiquitin makes its mark on immune regulation

31 March 2020

1 reference

Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling

31 March 2020

1 reference

Identification of the familial cylindromatosis tumour-suppressor gene

31 March 2020

1 reference

CYLD mutations in familial skin appendage tumours

31 March 2020

1 reference

CYLD: a tumor suppressor deubiquitinase regulating NF-kappaB activation and diverse biological processes

31 March 2020

1 reference

The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

31 March 2020

1 reference

Cyld inhibits tumor cell proliferation by blocking Bcl-3-dependent NF-kappaB signaling

31 March 2020

1 reference

Impaired regulation of NF-kappaB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

31 March 2020

1 reference

Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.

31 March 2020

1 reference

TNF-alpha induces two distinct caspase-8 activation pathways

31 March 2020

1 reference

cIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species production

31 March 2020

1 reference

Transgenic rescue of ataxia mice reveals a male-specific sterility defect

31 March 2020

1 reference

Ubiquitin and synaptic dysfunction: ataxic mice highlight new common themes in neurological disease

31 March 2020

1 reference

Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14

31 March 2020

1 reference

Enhancement of proteasome activity by a small-molecule inhibitor of USP14

31 March 2020

1 reference

Ubiquitin becomes ubiquitous in cancer: emerging roles of ubiquitin ligases and deubiquitinases in tumorigenesis and as therapeutic targets

31 March 2020

1 reference

FAM deubiquitylating enzyme is essential for preimplantation mouse embryo development

31 March 2020

1 reference

USP9X enhances the polarity and self-renewal of embryonic stem cell-derived neural progenitors

31 March 2020

1 reference

31 March 2020

The secret life of Smad4

1 reference

Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival

31 March 2020

1 reference

Ubiquitin-like sequence in ASK1 plays critical roles in the recognition and stabilization by USP9X and oxidative stress-induced cell death.

31 March 2020

1 reference

A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein

31 March 2020

1 reference

USP7 counteracts SCFbetaTrCP- but not APCCdh1-mediated proteolysis of Claspin

31 March 2020

1 reference

Hallmarks of Cancer: The Next Generation

31 March 2020

1 reference

Antiapoptotic drugs: a therapautic strategy for the prevention of neurodegenerative diseases.

31 March 2020

1 reference

Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas

31 March 2020

1 reference

The inhibitors of apoptosis (IAPs) as cancer targets

31 March 2020

1 reference

31 March 2020

Update on MALT lymphomas

1 reference

Constitutive NF-kappaB activation by the t(11;18)(q21;q21) product in MALT lymphoma is linked to deregulated ubiquitin ligase activity

31 March 2020

1 reference

Targeting inhibitor of apoptosis proteins for therapeutic intervention.

31 March 2020

1 reference

Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

31 March 2020

1 reference

The ubiquitin-editing enzyme A20 (TNFAIP3) is a central regulator of immunopathology

31 March 2020

1 reference

T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20

31 March 2020

1 reference

A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains.

31 March 2020

1 reference

A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme

31 March 2020

1 reference

Antagonists of IAP proteins as cancer therapeutics

31 March 2020

1 reference

Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls

31 March 2020

1 reference

The role of NF-kappaB in lymphoid malignancies

31 March 2020

1 reference

Generation and characterization of LymphoStat‐B, a human monoclonal antibody that antagonizes the bioactivities of B lymphocyte stimulator

31 March 2020

1 reference

Denosumab for prevention of fractures in postmenopausal women with osteoporosis

31 March 2020

1 reference

ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor

31 March 2020

1 reference

The IkappaB kinase - a bridge between inflammation and cancer

31 March 2020

1 reference

Translating p53 into the clinic.

31 March 2020

1 reference

Restoring p53 function in cancer: novel therapeutic approaches for applying the brakes to tumorigenesis

31 March 2020

1 reference

The p53 pathway as a target in cancer therapeutics: obstacles and promise

31 March 2020

1 reference

Reactivation of p53: from peptides to small molecules.

31 March 2020

1 reference

The ubiquitin system, disease, and drug discovery

31 March 2020

1 reference

Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells

31 March 2020

1 reference

Deubiquitinating enzymes as novel anticancer targets

31 March 2020

1 reference

Development of the proteasome inhibitor Velcade (Bortezomib).

31 March 2020

1 reference

Mechanisms of proteasome inhibitor action and resistance in cancer

31 March 2020

1 reference

Therapeutic strategies within the ubiquitin proteasome system.

31 March 2020

1 reference

Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer

31 March 2020

1 reference

The multiple levels of regulation by p53 ubiquitination

31 March 2020

1 reference

Tumour suppression: disruption of HAUSP gene stabilizes p53

31 March 2020

1 reference

Inactivation of HAUSP in vivo modulates p53 function

31 March 2020

1 reference

Roles of HAUSP-mediated p53 regulation in central nervous system development

31 March 2020

1 reference

ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation

31 March 2020

1 reference

Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes

31 March 2020

1 reference

12 December 2020

The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas

1 reference

12 December 2020

Emerging roles of deubiquitinases in cancer-associated pathways

1 reference

12 December 2020

Small-molecule inhibitors of the p53-MDM2 interaction

1 reference

12 December 2020

Cancer chemoprevention by targeting the epigenome.

1 reference

12 December 2020

Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements

1 reference

12 December 2020

Inhibition of homologue of Slimb (HOS) function sensitizes human melanoma cells for apoptosis

1 reference

12 December 2020

Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin

1 reference

12 December 2020

Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM3143

1 reference

24 August 2017

1 reference

PubMed ID

21697901