(Q51898177)

17 April 2018

title

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. (English)

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17 April 2018

stem cell differentiation

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7

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17 April 2018

Anett Jandke

object named as

Anett Jandke

2

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author name string

Joerg D Hoeck

1

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17 April 2018

Sophia M Blake

3

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17 April 2018

Emma Nye

4

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17 April 2018

Bradley Spencer-Dene

5

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17 April 2018

Sebastian Brandner

6

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17 April 2018

language of work or name

English

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publication date

10 October 2010

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17 April 2018

published in

Nature Neuroscience

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17 April 2018

volume

13

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17 April 2018

issue

11

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17 April 2018

page(s)

1365-1372

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17 April 2018

https://scigraph.springernature.com/pub.10.1038/nn.2644

exact match

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cites work

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

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12 December 2020

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

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12 December 2020

The AP-1 transcription factor c-Jun is required for efficient axonal regeneration

1 reference

12 December 2020

Glial cell fate specification modulated by the bHLH gene Hes5 in mouse retina

1 reference

12 December 2020

c-Jun N-terminal protein kinase (JNK) 2/3 is specifically activated by stress, mediating c-Jun activation, in the presence of constitutive JNK1 activity in cerebellar neurons.

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12 December 2020

Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells

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12 December 2020

Impaired intervertebral disc formation in the absence of Jun.

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12 December 2020

Radial glia serve as neuronal progenitors in all regions of the central nervous system

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12 December 2020

The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1

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12 December 2020

Radial glial cells defined and major intermediates between embryonic stem cells and CNS neurons

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12 December 2020

Both SCF(Cdc4alpha) and SCF(Cdc4gamma) are required for cyclin E turnover in cell lines that do not overexpress cyclin E.

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12 December 2020

Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development.

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12 December 2020

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

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12 December 2020

Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration.

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12 December 2020

F-box proteins: the key to protein degradation

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12 December 2020

Induction of apoptosis by the transcription factor c-Jun

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12 December 2020

Conservation of the Notch signalling pathway in mammalian neurogenesis

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12 December 2020

Neural stem cells in mammalian development

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12 December 2020

Differential Notch signalling distinguishes neural stem cells from intermediate progenitors.

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12 December 2020

Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells

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12 December 2020

Tumor suppressor activities of the Fbw7 E3 ubiquitin ligase receptor

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12 December 2020

The limited role of NH2-terminal c-Jun phosphorylation in neuronal apoptosis: identification of the nuclear pore complex as a potential target of the JNK pathway.

1 reference

12 December 2020

Targeted deletion of the mitogen-activated protein kinase kinase 4 gene in the nervous system causes severe brain developmental defects and premature death

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12 December 2020

JNK1 Is Required for Maintenance of Neuronal Microtubules and Controls Phosphorylation of Microtubule-Associated Proteins

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12 December 2020

The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling

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12 December 2020

Characterization of CNS precursor subtypes and radial glia

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12 December 2020

Radial glial identity is promoted by Notch1 signaling in the murine forebrain

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12 December 2020

Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release

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12 December 2020

The Fbxw7/hCdc4 tumor suppressor in human cancer

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12 December 2020

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL.

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12 December 2020

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

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12 December 2020

Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms

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12 December 2020

Neural stem cells and neurospheres--re-evaluating the relationship.

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12 December 2020

Regulation of neural progenitor cell development in the nervous system

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12 December 2020

Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development

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12 December 2020

Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation.

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12 December 2020

dp5/HRK is a c-Jun target gene and required for apoptosis induced by potassium deprivation in cerebellar granule neurons

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12 December 2020

Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb

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12 December 2020

Brain lipid-binding protein is a direct target of Notch signaling in radial glial cells

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12 December 2020

Adherent neural stem (NS) cells from fetal and adult forebrain

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12 December 2020

A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size

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12 December 2020

Defective cardiovascular development and elevated cyclin E and Notch proteins in mice lacking the Fbw7 F-box protein

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12 December 2020

Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation

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12 December 2020

Control of hematopoietic stem cell quiescence by the E3 ubiquitin ligase Fbw7

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12 December 2020

Notch signaling in the mammalian central nervous system: insights from mouse mutants

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12 December 2020

Identifiers

DOI

10.1038/NN.2644

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17 April 2018

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17 April 2018