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The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing
scientific article published on 3 March 2009
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scholarly article
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
title
The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing
(English)
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
main subject
protein ubiquitination
1 reference
based on heuristic
inferred from title
author name string
Young Eun Choi
series ordinal
1
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
Michael Butterworth
series ordinal
2
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
Srinivas Malladi
series ordinal
3
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
Colin S Duckett
series ordinal
4
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
Gerald M Cohen
series ordinal
5
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
Shawn B Bratton
series ordinal
6
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
language of work or name
English
0 references
publication date
3 March 2009
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
published in
Journal of Biological Chemistry
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
volume
284
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stated in
Q5412157
PMCID
2676007
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14 November 2017
page(s)
12772-12782
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stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
issue
19
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Q5412157
PMCID
2676007
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14 November 2017
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Executioner caspase-3 and caspase-7 are functionally distinct proteases
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Targeted peptidecentric proteomics reveals caspase-7 as a substrate of the caspase-1 inflammasomes
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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
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TNF-alpha induces two distinct caspase-8 activation pathways
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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
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Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma.
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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
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The apoptosome activates caspase-9 by dimerization
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The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases
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Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
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Nuclear substructure reorganization during late-stage erythropoiesis is selective and does not involve caspase cleavage of major nuclear substructural proteins
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cIAP1 Localizes to the nuclear compartment and modulates the cell cycle
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25 May 2018
XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.
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25 May 2018
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms
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The protein structures that shape caspase activity, specificity, activation and inhibition
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25 May 2018
Nuclear shuttling and TRAF2-mediated retention in the cytoplasm regulate the subcellular localization of cIAP1 and cIAP2.
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PubMed Central
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25 May 2018
Molecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitination
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25 May 2018
Death receptors leave a caspase footprint that Smacs of XIAP.
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25 May 2018
A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes.
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25 May 2018
Mechanism of XIAP-mediated inhibition of caspase-9
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A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO
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25 May 2018
Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy
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IAP proteins: blocking the road to death's door
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25 May 2018
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25 May 2018
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
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PubMed Central
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25 May 2018
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
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PubMed Central
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25 May 2018
The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Structural basis for the inhibition of caspase-3 by XIAP
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Structural basis of caspase-7 inhibition by XIAP
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Detecting and measuring cotranslational protein degradation in vivo
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
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PubMed Central
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25 May 2018
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
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PubMed Central
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25 May 2018
The inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7
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PubMed Central
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25 May 2018
Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis
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25 May 2018
The Drosophila caspase DRONC is regulated by DIAP1
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Caspase-9 and APAF-1 form an active holoenzyme
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7.
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PubMed Central
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25 May 2018
Caspases: preparation and characterization
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PubMed Central
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25 May 2018
IAP family proteins--suppressors of apoptosis
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Inhibition of human caspases by peptide-based and macromolecular inhibitors
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
A role for caspases in lens fiber differentiation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control
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PubMed Central
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25 May 2018
Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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25 May 2018
Role of the executioner caspases during lens development.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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15 August 2018
The canonical intrinsic mitochondrial death pathway has a non-apoptotic role in signaling lens cell differentiation
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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15 August 2018
Preservation of caspase-3 subunits from degradation contributes to apoptosis evoked by lactacystin: any single lysine or lysine pair of the small subunit is sufficient for ubiquitination
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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15 August 2018
Human caspase-7 activity and regulation by its N-terminal peptide.
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15 August 2018
XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2676007
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15 August 2018
Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/19258326
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Neural stem cell differentiation is dependent upon endogenous caspase 3 activity
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19258326
retrieved
12 December 2020
based on heuristic
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Purification and catalytic properties of human caspase family members
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/19258326
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1074/JBC.M807550200
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
PMCID
2676007
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
PubMed ID
19258326
1 reference
stated in
Q5412157
PMCID
2676007
retrieved
14 November 2017
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