(Q29347540)

11 April 2017

G2385R and I2020T Mutations Increase LRRK2 GTPase Activity (English)

1 reference

11 April 2017

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Hyemyung Seo

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

4

Ilhong Son

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Jihoon Jang

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Eun-Hye Joe

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Wongi Seol

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

language of work or name

English

0 references

publication date

25 May 2016

1 reference

BioMed Research International

11 April 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

volume

2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

page(s)

7917128

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

9 June 2020

copyright license

start time

1 January 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

1 reference

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An early endosome regulator, Rab5b, is an LRRK2 kinase substrate

11 April 2017

1 reference

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The role of the LRRK2 gene in Parkinsonism

11 April 2017

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Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain

11 April 2017

1 reference

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Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain

11 April 2017

1 reference

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GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

11 April 2017

1 reference

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The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

11 April 2017

1 reference

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Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

11 April 2017

1 reference

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

11 April 2017

1 reference

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LRRK2 regulates synaptic vesicle endocytosis

11 April 2017

1 reference

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The R1441C mutation of LRRK2 disrupts GTP hydrolysis

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Identification of a common genetic risk variant (LRRK2 Gly2385Arg) in Parkinson's disease

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Localization of LRRK2 to membranous and vesicular structures in mammalian brain

11 April 2017

1 reference

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LRRK2 in Parkinson's disease: protein domains and functional insights

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

11 April 2017

1 reference

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

11 April 2017

1 reference

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Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

11 April 2017

1 reference

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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

11 April 2017

1 reference

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Sar1 GTPase Activity Is Regulated by Membrane Curvature.

11 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

LRRK2 autophosphorylation enhances its GTPase activity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

LRRK2 Pathways Leading to Neurodegeneration

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Chemical Biology of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors

3 June 2018

1 reference

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Cellular processes associated with LRRK2 function and dysfunction

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Contribution of GTPase activity to LRRK2-associated Parkinson disease

3 June 2018

1 reference

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Impaired inflammatory responses in murine Lrrk2-knockdown brain microglia

3 June 2018

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Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form

3 June 2018

1 reference

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Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation

3 June 2018

1 reference

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Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study

3 June 2018

1 reference

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LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Biochemical and molecular features of LRRK2 and its pathophysiological roles in Parkinson's disease

3 June 2018

1 reference

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GTPase activity plays a key role in the pathobiology of LRRK2.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

The WD40 domain is required for LRRK2 neurotoxicity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4897664

The G2019S LRRK2 mutation is uncommon in an Asian cohort of Parkinson's disease patients.

3 June 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F7917128

Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F7917128

The LRRK2 G2385R variant is a risk factor for sporadic Parkinson's disease in the Korean population

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F7917128

Multiple LRRK2 variants modulate risk of Parkinson disease: a Chinese multicenter study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F7917128

CNF1 exploits the ubiquitin-proteasome machinery to restrict Rho GTPase activation for bacterial host cell invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F7917128

LRRK2 I2020T mutation is associated with tau pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F7917128

Lrrk2 pathogenic substitutions in Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F7917128

LRRK2G2019S as a Cause of Parkinson's Disease in North African Arabs

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2016%2F7917128

A common missense variant in the LRRK2 gene, Gly2385Arg, associated with Parkinson's disease risk in Taiwan

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27314038

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1155/2016/7917128

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27314038%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

2 references