(Q30160092)

8 June 2017

title

Cdc42 induces activation loop phosphorylation and membrane targeting of mixed lineage kinase 3. (English)

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8 June 2017

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Yan Du

1

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8 June 2017

Barbara C Böck

2

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8 June 2017

Karen A Schachter

3

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8 June 2017

Mary Chao

4

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8 June 2017

Kathleen A Gallo

5

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8 June 2017

language of work or name

English

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publication date

27 October 2005

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Journal of Biological Chemistry

8 June 2017

number of pages

10

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based on heuristic

inferred from page(s)

published in

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8 June 2017

volume

280

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8 June 2017

issue

52

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8 June 2017

page(s)

42984-42993

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The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.

8 June 2017

cites work

1 reference

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Mixed-lineage kinase control of JNK and p38 MAPK pathways

21 January 2018

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Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper

21 January 2018

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The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis

21 January 2018

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Mixed-lineage kinases: a target for the prevention of neurodegeneration

21 January 2018

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Activation of the Drosophila MLK by ceramide reveals TNF-alpha and ceramide as agonists of mammalian MLK3.

21 January 2018

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Hsp90/p50cdc37 is required for mixed-lineage kinase (MLK) 3 signaling

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M502671200

Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade

21 January 2018

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Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M502671200

Mixed lineage kinase 3 (MLK3)-activated p38 MAP kinase mediates transforming growth factor-beta-induced apoptosis in hepatoma cells

21 January 2018

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MLK3 is required for mitogen activation of B-Raf, ERK and cell proliferation

21 January 2018

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A novel role for mixed lineage kinase 3 (MLK3) in B-Raf activation and cell proliferation

21 January 2018

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Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3

21 January 2018

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Zipper-mediated oligomerization of the mixed lineage kinase SPRK/MLK-3 is not required for its activation by the GTPase cdc 42 but Is necessary for its activation of the JNK pathway. Monomeric SPRK L410P does not catalyze the activating phosphorylat

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Autoinhibition of mixed lineage kinase 3 through its Src homology 3 domain

21 January 2018

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The kinase activation loop is the key to mixed lineage kinase-3 activation via both autophosphorylation and hematopoietic progenitor kinase 1 phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M502671200

Negative regulation of mixed lineage kinase 3 by protein kinase B/AKT leads to cell survival

21 January 2018

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Identification of in vivo phosphorylation sites of MLK3 by mass spectrometry and phosphopeptide mapping

21 January 2018

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Cdc42: new roads to travel

21 January 2018

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Human RAS superfamily proteins and related GTPases

21 January 2018

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Rho-family GTPases: it's not only Rac and Rho (and I like it).

21 January 2018

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Cell migration: Rho GTPases lead the way

21 January 2018

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Multiple roles for Cdc42 in cell regulation

21 January 2018

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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

21 January 2018

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Protein prenyltransferases

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M502671200

All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Cdc42-induced activation of the mixed-lineage kinase SPRK in vivo. Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation

21 January 2018

1 reference

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Activation of Raf as a result of recruitment to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Mutational analysis of CDC42Sc, a Saccharomyces cerevisiae gene that encodes a putative GTP-binding protein involved in the control of cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

The gamma-subunit of the coatomer complex binds Cdc42 to mediate transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Phosphorylation of golgin-160 by mixed lineage kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

A new identity for MLK3 as an NIMA-related, cell cycle-regulated kinase that is localized near centrosomes and influences microtubule organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

The conformational plasticity of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Crystal structure of the TAO2 kinase domain: activation and specificity of a Ste20p MAP3K

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Active and inactive protein kinases: structural basis for regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Regulation of protein kinases; controlling activity through activation segment conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Activation of endogenous Cdc42 visualized in living cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Imaging activation of two Ras isoforms simultaneously in a single cell.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Association of Cdc42/N-WASP/Arp2/3 signaling pathway with Golgi membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Biology of the p21-activated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Mixed lineage kinase-dependent JNK activation is governed by interactions of scaffold protein JIP with MAPK module components

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

The complexity of Raf-1 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Physical association with ras enhances activation of membrane-bound raf (RafCAAX).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

The RAF proteins take centre stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Positive and negative regulation of Raf kinase activity and function by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Differential regulation of Raf-1, A-Raf, and B-Raf by oncogenic ras and tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Signaling by the germinal center kinase family of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

In its active form, the GTP-binding protein rab8 interacts with a stress-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M502671200

21 January 2018

Identifiers

DOI

10.1074/JBC.M502671200

1 reference

8 June 2017

1 reference