(Q30268449)

13 June 2017

title

Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights (English)

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13 June 2017

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Christoph von Ballmoos

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Povilas Uzdavinys

4

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Oliver Beckstein

8

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David L Dotson

object named as

David L Dotson

3

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David Drew

object named as

David Drew

9

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Alexander Cameron

object named as

Alexander D Cameron

10

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author name string

Chiara Lee

1

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13 June 2017

Shoko Yashiro

2

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13 June 2017

So Iwata

5

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13 June 2017

Mark S P Sansom

6

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13 June 2017

publication date

1 December 2014

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The Journal of General Physiology

13 June 2017

published in

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13 June 2017

volume

144

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13 June 2017

issue

6

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13 June 2017

page(s)

529-544

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

13 June 2017

cites work

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Arginine residues at internal positions in a protein are always charged

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Transmembrane segment II of NhaA Na+/H+ antiporter lines the cation passage, and Asp65 is critical for pH activation of the antiporter

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21 January 2018

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Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH.

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21 January 2018

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Relationship between ion pair geometries and electrostatic strengths in proteins

21 January 2018

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Model structure of the Na+/H+ exchanger 1 (NHE1): functional and clinical implications

21 January 2018

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Revealing the ligand binding site of NhaA Na+/H+ antiporter and its pH dependence

21 January 2018

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Transport mechanism and pH regulation of the Na+/H+ antiporter NhaA from Escherichia coli: an electrophysiological study

21 January 2018

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21 January 2018

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21 January 2018

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Combined computational and biochemical study reveals the importance of electrostatic interactions between the "pH sensor" and the cation binding site of the sodium/proton antiporter NhaA of Escherichia coli.

21 January 2018

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Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

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The enlightening encounter between structure and function in the NhaA Na+-H+ antiporter

21 January 2018

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NhaA of Escherichia coli, as a model of a pH-regulated Na+/H+antiporter

21 January 2018

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NhaA crystal structure: functional-structural insights

21 January 2018

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21 January 2018

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21 January 2018

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Mechanism of the lamellar/inverse hexagonal phase transition examined by high resolution x-ray diffraction

21 January 2018

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Monomers of the NhaA Na+/H+ antiporter of Escherichia coli are fully functional yet dimers are beneficial under extreme stress conditions at alkaline pH in the presence of Na+ or Li+.

21 January 2018

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Model-guided mutagenesis drives functional studies of human NHA2, implicated in hypertension

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

21 January 2018

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Considerations for the refinement of low-resolution crystal structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201411219

Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli

21 January 2018

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Molecular dynamics with coupling to an external bath

21 January 2018

1 reference

https://api.crossref.org/works/10.1085%2FJGP.201411219

Electron-density map interpretation

21 January 2018

1 reference

PubMed Central

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Proton-sodium stoichiometry of NhaA, an electrogenic antiporter from Escherichia coli

26 November 2018

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Evidence that Na+/H+ exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers.

26 November 2018

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Overproduction and purification of a functional Na+/H+ antiporter coded by nhaA (ant) from Escherichia coli

26 November 2018

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12 December 2020

Structure of fully hydrated fluid phase lipid bilayers with monounsaturated chains

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12 December 2020

Beta-sheet-dependent dimerization is essential for the stability of NhaA Na+/H+ antiporter

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12 December 2020

Mechanism and kinetics of peptide partitioning into membranes from all-atom simulations of thermostable peptides

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12 December 2020

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Halide, Ammonium, and Alkali Metal Ion Parameters for Modeling Aqueous Solutions

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12 December 2020

Essential aspartic acid residues, Asp-133, Asp-163 and Asp-164, in the transmembrane helices of a Na+/H+ antiporter (NhaA) from Escherichia coli

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12 December 2020

Identifiers

DOI

10.1085/JGP.201411219

1 reference

13 June 2017

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