(Q30353954)

19 August 2017

Structural determinants of Tau aggregation inhibitor potency (English)

1 reference

19 August 2017

Kelsey N Schafer

1

1 reference

19 August 2017

Katryna Cisek

2

1 reference

19 August 2017

Carol J Huseby

3

1 reference

19 August 2017

Edward Chang

4

1 reference

19 August 2017

Jeff Kuret

5

1 reference

19 August 2017

language of work or name

English

0 references

publication date

26 September 2013

1 reference

Journal of Biological Chemistry

19 August 2017

1 reference

19 August 2017

288

1 reference

19 August 2017

45

1 reference

19 August 2017

32599-32611

1 reference

Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Ligand electronic properties modulate tau filament binding site density

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Aggregation of α-synuclein is kinetically controlled by intramolecular diffusion

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

QSAR studies for prediction of cross-β sheet aggregate binding affinity and selectivity

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Research towards tau imaging

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Structure-activity relationship of cyclic thiacarbocyanine tau aggregation inhibitors.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

The acetylation of tau inhibits its function and promotes pathological tau aggregation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Preparation and characterization of neurotoxic tau oligomers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Amyloid beta 42 peptide (Abeta42)-lowering compounds directly bind to Abeta and interfere with amyloid precursor protein (APP) transmembrane dimerization

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Tau protein and tau aggregation inhibitors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

The mysterious unfoldome: structureless, underappreciated, yet vital part of any given proteome

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Structural and mechanistic basis behind the inhibitory interaction of PcTS on alpha-synuclein amyloid fibril formation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Inhibition of tau polymerization with a cyanine dye in two distinct model systems

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Structure-activity relationship of cyanine tau aggregation inhibitors.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Accurate simulation of optical properties in dyes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Robust cross-validation of linear regression QSAR models

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Pathogenic missense MAPT mutations differentially modulate tau aggregation propensity at nucleation and extension steps

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Structural characteristics of alpha-synuclein oligomers stabilized by the flavonoid baicalein

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Is tau aggregation toxic or protective?

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Tau aggregation and toxicity in tauopathic neurodegenerative diseases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomers

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constants

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Rhodanine-based tau aggregation inhibitors in cell models of tauopathy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Differentiating Alzheimer disease-associated aggregates with small molecules

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Granular tau oligomers as intermediates of tau filaments

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Small molecule inhibitors of alpha-synuclein filament assembly

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Evaluating triggers and enhancers of tau fibrillization.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Pathways of tau fibrillization.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

A static laser light scattering assay for surfactant-induced tau fibrillization

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

The role of tau (MAPT) in frontotemporal dementia and related tauopathies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Casein kinase 1 delta phosphorylates tau and disrupts its binding to microtubules

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Effect of detergent on "promiscuous" inhibitors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Estimation of aqueous solubility of chemical compounds using E-state indices

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Oxidative regulation of fatty acid-induced tau polymerization.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Differential assembly of human tau isoforms in the presence of arachidonic acid

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

The structural basis of monoclonal antibody Alz50's selectivity for Alzheimer's disease pathology.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Functional implications for the microtubule-associated protein tau: localization in oligodendrocytes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Ligand-dependent inhibition and reversal of tau filament formation

3 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Ligand polarizability contributes to tau fibril binding affinity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Inhibition of tau filament formation by conformational modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Adsorption of dyes onto activated carbon cloth: using QSPRs as tools to approach adsorption mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Anionic Micelles and Vesicles Induce Tau Fibrillization in Vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

A survey of Hammett substituent constants and resonance and field parameters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Prediction of n-octanol/water partition coefficients from PHYSPROP database using artificial neural networks and E-state indices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Development of a computational approach to predict blood-brain barrier permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Inhibition of alpha-synuclein fibril assembly by small molecules: analysis using epitope-specific antibodies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Site-specific pseudophosphorylation modulates the rate of tau filament dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Possible role of each repeat structure of the microtubule-binding domain of the tau protein in in vitro aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

Alzheimer's Disease: Insolubility of Partially Purified Paired Helical Filaments in Sodium Dodecyl Sulfate and Urea

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M113.503474

C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3820892

Classifying environmental pollutants: Part 3. External validation of the classification system

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24072703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Color and constitution: one hundred years of research

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24072703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local beta-structure

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24072703

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M113.503474

1 reference

19 August 2017

1 reference

19 August 2017

PubMed publication ID

24072703

1 reference