(Q30370390)

16 October 2017

Contributions of ionic interactions and protein dynamics to cytochrome P450 2D6 (CYP2D6) substrate and inhibitor binding. (English)

1 reference

16 October 2017

An Wang

1

1 reference

16 October 2017

C David Stout

series ordinal

2

1 reference

16 October 2017

Qinghai Zhang

series ordinal

3

1 reference

16 October 2017

Eric F Johnson

series ordinal

4

1 reference

16 October 2017

language of work or name

English

0 references

publication date

1 January 2015

1 reference

Journal of Biological Chemistry

16 October 2017

1 reference

16 October 2017

290

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16 October 2017

8

1 reference

16 October 2017

5092-5104

1 reference

describes a project that uses

16 October 2017

PyMOL

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/efetch.fcgi?db=pmc&rettype=xml&id=PMC4335244

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Correlating structure and function of drug-metabolizing enzymes: progress and ongoing challenges.

3 June 2018

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3 June 2018

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Structural diversity of eukaryotic membrane cytochrome p450s

3 June 2018

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Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins

3 June 2018

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Conformational Adaptation of Human Cytochrome P450 2B6 and Rabbit Cytochrome P450 2B4 Revealed upon Binding Multiple Amlodipine Molecules

3 June 2018

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Nicotine and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone Binding and Access Channel in Human Cytochrome P450 2A6 and 2A13 Enzymes

3 June 2018

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Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution

3 June 2018

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Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound

3 June 2018

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Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants

3 June 2018

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3 June 2018

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Prediction of CYP2D6 drug interactions from in vitro data: evidence for substrate-dependent inhibition

3 June 2018

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Data processing and analysis with the autoPROC toolbox

3 June 2018

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Features and development of Coot

3 June 2018

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

3 June 2018

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Crystal Structure of CYP24A1, a Mitochondrial Cytochrome P450 Involved in Vitamin D Metabolism

3 June 2018

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New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme

3 June 2018

1 reference

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Version 1.2 of the Crystallography and NMR system

3 June 2018

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The ins and outs of cytochrome P450s.

3 June 2018

1 reference

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Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.

3 June 2018

1 reference

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Crystal structure of human cytochrome P450 2D6

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335244

Characterization of human cytochrome p450 enzymes involved in the metabolism of the piperidine-type phenothiazine neuroleptic thioridazine

3 June 2018

1 reference

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Likelihood-enhanced fast translation functions

3 June 2018

1 reference

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Detection, delineation, measurement and display of cavities in macromolecular structures

3 June 2018

1 reference

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PRODRG: a tool for high-throughput crystallography of protein-ligand complexes

3 June 2018

1 reference

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An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

3 June 2018

1 reference

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THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335244

Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335244

Plasma levels of the enantiomers of thioridazine, thioridazine 2-sulfoxide, thioridazine 2-sulfone, and thioridazine 5-sulfoxide in poor and extensive metabolizers of dextromethorphan and mephenytoin.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335244

Development of a pharmacophore for inhibition of human liver cytochrome P-450 2D6: molecular modeling and inhibition studies

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335244

Biologically active conformers of phenothiazines and thioxanthenes. Further evidence for a ligand model of dopamine D2 receptor antagonists

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335244

"It's the genes, stupid". Molecular bases and clinical consequences of genetic cytochrome P450 2D6 polymorphism

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335244

Greater potency of mesoridazine and sulforidazine compared with the parent compound, thioridazine, on striatal dopamine autoreceptors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4335244

Metabolic activation of the phenothiazine antipsychotics chlorpromazine and thioridazine to electrophilic iminoquinone species in human liver microsomes and recombinant P450s.

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.627661

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.627661

Change in enantioselectivity in bufuralol 1''-hydroxylation by the substitution of phenylalanine-120 by alanine in cytochrome P450 2D6.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1074%2FJBC.M114.627661

Novel approach to predicting P450-mediated drug metabolism: development of a combined protein and pharmacophore model for CYP2D6

21 January 2018

1 reference

12 December 2020

Xenobiotic and endobiotic inhibitors of cytochrome P-450dbl function, the target of the debrisoquine/sparteine type polymorphism

1 reference

12 December 2020

Measurement of Michaelis constants for cytochrome P450-mediated biotransformation reactions using a substrate depletion approach

1 reference

12 December 2020

Clinical implications of slow sulphoxidation of thioridazine in a poor metabolizer of the debrisoquine type

1 reference

12 December 2020

Plasma levels of thioridazine and metabolites are influenced by the debrisoquin hydroxylation phenotype

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M114.627661

1 reference

16 October 2017

1 reference

16 October 2017

1 reference