(Q30383886)

21 June 2017

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title

Fragile histidine triad protein: structure, function, and its association with tumorogenesis. (English)

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21 June 2017

Md Imtaiyaz Hassan

1

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21 June 2017

Abdullah Naiyer

series ordinal

2

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21 June 2017

Faizan Ahmad

series ordinal

3

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21 June 2017

publication date

24 December 2009

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Journal of Cancer Research and Clinical Oncology

21 June 2017

published in

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21 June 2017

volume

136

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21 June 2017

issue

3

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21 June 2017

page(s)

333-350

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Loss of FHIT expression in transitional cell carcinoma of the urinary bladder

21 June 2017

cites work

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https://api.crossref.org/works/10.1007%2FS00432-009-0751-9

Fhit expression protects against HER2-driven breast tumor development: unraveling the molecular interconnections

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-009-0751-9

Aberrant transcripts of the FHIT gene are expressed in normal and leukaemic haemopoietic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-009-0751-9

Beta-catenin takes a HIT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-009-0751-9

Characterization of aberrant FHIT transcripts in gastric adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-009-0751-9

FHIT as tumor suppressor: mechanisms and therapeutic opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-009-0751-9

Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-009-0751-9

Chromosomal fragile sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-009-0751-9

Molecular genetics of small cell lung carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00432-009-0751-9

The Saccharomyces cerevisiae RAD9, RAD17, RAD24 and MEC3 genes are required for tolerating irreparable, ultraviolet-induced DNA damage

21 January 2018

1 reference

12 December 2020

The FHIT gene is alternatively spliced in normal kidney and renal cell carcinoma

1 reference

12 December 2020

DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes

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12 December 2020

Nicotine induces the fragile histidine triad methylation in human esophageal squamous epithelial cells.

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12 December 2020

FRA3B extends over a broad region and contains a spontaneous HPV16 integration site: direct evidence for the coincidence of viral integration sites and fragile sites

1 reference

12 December 2020

Nit1 and Fhit tumor suppressor activities are additive

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12 December 2020

Ubc9-induced inhibition of diadenosine triphosphate hydrolase activity of the putative tumor suppressor protein Fhit

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12 December 2020

Effect of aberrant promoter methylation of FHIT and RASSF1A genes on susceptibility to cervical cancer in a North Indian population

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12 December 2020

Clinicopathological significance of fragile histidine triad transcription protein expression in breast carcinoma.

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12 December 2020

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding

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12 December 2020

A novel method for improving Streptomyces coelicolor A3(2) for production of actinorhodin by introduction of rpsL (encoding ribosomal protein S12) mutations conferring resistance to streptomycin

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12 December 2020

Molecular and cytogenetical alterations induced by environmental cigarette smoke in mice heterozygous for Fhit

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12 December 2020

The FHIT gene at 3p14.2 is abnormal in breast carcinomas

1 reference

12 December 2020

Fez1/lzts1 alterations in gastric carcinoma.

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12 December 2020

Large common fragile site genes and cancer

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12 December 2020

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12 December 2020

Fhit protein expression in lung cancer studied by high-throughput tissue microarray.

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12 December 2020

Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant

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12 December 2020

Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours

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12 December 2020

Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans

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12 December 2020

Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit

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12 December 2020

The FHIT gene is expressed in pancreatic ductular cells and is altered in pancreatic cancers

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12 December 2020

How many tumor suppressor genes are involved in human lung carcinogenesis?

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12 December 2020

Cancer statistics, 1995.

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12 December 2020

A tumor suppressor locus within 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo

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12 December 2020

A domain within the tumor suppressor protein APC shows very similar biochemical properties as the microtubule-associated protein tau.

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12 December 2020

Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5"'-P1,P3-triphosphate hydrolase

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12 December 2020

The DNA sequence, annotation and analysis of human chromosome 3

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12 December 2020

Alterations of the fragile histidine triad gene, FHIT, and its encoded products contribute to testicular germ cell tumorigenesis

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12 December 2020

Fragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic

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12 December 2020

Copy-number variants in patients with a strong family history of pancreatic cancer

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12 December 2020

Structure and specificity of a human valacyclovir activating enzyme: a homology model of BPHL.

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12 December 2020

High resolution analysis of chromosome 3p alterations in cervical carcinoma.

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12 December 2020

The apoptotic pathway triggered by the Fhit protein in lung cancer cell lines is not affected by Bcl-2 or Bcl-x(L) overexpression

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12 December 2020

Frequent deletions of FHIT and FRA3B in Barrett's metaplasia and esophageal adenocarcinomas

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12 December 2020

FHIT gene and the FRA3B region are not involved in the genetics of renal cell carcinomas

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12 December 2020

Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma

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12 December 2020

Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2.

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12 December 2020

Muir-Torre-like syndrome in Fhit-deficient mice

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12 December 2020

Loss of FHIT expression in cervical carcinoma cell lines and primary tumors.

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12 December 2020

Genetics of renal-cell carcinoma and evidence for a critical role for von Hippel-Lindau in renal tumorigenesis.

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12 December 2020

STRING 8--a global view on proteins and their functional interactions in 630 organisms

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12 December 2020

Tumor-specific and HLA-A2-restricted cytolysis by tumor-associated lymphocytes in human metastatic breast cancer

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12 December 2020

Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis

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12 December 2020

Clinical significance of fragile histidine triad gene expression in adult acute lymphoblastic leukemia

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12 December 2020

Abnormal FHIT transcripts in human breast carcinomas: a clinicopathological and epidemiological analysis of 61 Japanese cases.

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12 December 2020

Genome-wide analysis of genetic alterations in Barrett's adenocarcinoma using single nucleotide polymorphism arrays

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12 December 2020

Molecular Pathogenesis of Lung Cancer

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12 December 2020

[FHIT--tumor suppressor protein involved in induction of apoptosis and cell cycle regulation].

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12 December 2020

Frequent aberration of FHIT gene expression in acute leukemias.

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12 December 2020

Hypermethylation of the 5' CpG island of the FHIT gene is associated with hyperdiploid and translocation-negative subtypes of pediatric leukemia

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12 December 2020

Structure and expression of the human FHIT gene in normal and tumor cells.

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12 December 2020

FHIT mutations in human primary gastric cancer

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12 December 2020

Down-regulation of FHIT inhibits apoptosis of colorectal cancer: mechanism and clinical implication.

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12 December 2020

The murine Fhit locus: isolation, characterization, and expression in normal and tumor cells

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12 December 2020

Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers

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12 December 2020

Translocation t(3;8)(p14.2;q24.1) in renal cell carcinoma affects expression of the common fragile site at 3p14(FRA3B) in lymphocytes

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12 December 2020

Fragile gene product, Fhit, in oxidative and replicative stress responses

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12 December 2020

Diadenosine oligophosphates (Ap(n)A), a novel class of signalling molecules?

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12 December 2020

Effects of insulin receptor down-regulation on hexose transport in human erythrocytes

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12 December 2020

The FHIT and PTPRG genes are deleted in benign proliferative breast disease associated with familial breast cancer and cytogenetic rearrangements of chromosome band 3p14

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12 December 2020

Methylation of the 5' CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas

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12 December 2020

[Embryonal carcinoma (Higuchi, Kato) of the ovary, clinical analysis and recent improvement of treatment using alpha FP as a tumor marker]

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12 December 2020

Chasing the cancer demon

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12 December 2020

Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9

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12 December 2020

Induction of apoptosis and inhibition of tumorigenicity and tumor growth by adenovirus vector-mediated fragile histidine triad (FHIT) gene overexpression

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12 December 2020

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

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12 December 2020

The prolactin-inducible protein (PIP/GCDFP-15) gene: cloning, structure and regulation

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12 December 2020

Aberrant FHIT protein expression in classical Hodgkin's lymphoma: a potential marker

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12 December 2020

Inverse correlation of aberrant expression of fragile histidine triad (FHIT) protein with cyclin D1 protein and prognosis in Chinese patients with cholangiocarcinoma

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12 December 2020

Origin and evolution of gene for prolactin-induced protein

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12 December 2020

Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor

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12 December 2020

The candidate tumor suppressor gene, RASSF1A, from human chromosome 3p21.3 is involved in kidney tumorigenesis

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12 December 2020

Analysis of the fragile histidine triad gene in primary gastric carcinomas and gastric carcinoma cell lines

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12 December 2020

Fragile histidine triad protein, WW domain-containing oxidoreductase protein Wwox, and activator protein 2gamma expression levels correlate with basal phenotype in breast cancer

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12 December 2020

Re: Helicobacter pylori and atrophic gastritis: importance of the cagA status

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12 December 2020

5'-CpG island methylation of the FHIT gene is associated with reduced protein expression and higher clinical stage in cervical carcinomas

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12 December 2020

Loss of fhit expression in invasive cervical carcinomas and intraepithelial lesions associated with invasive disease

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12 December 2020

The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.

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12 December 2020

A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma

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12 December 2020

The role of the FHIT/FRA3B locus in cancer

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12 December 2020

Absence of Fhit protein in primary lung tumors and cell lines with FHIT gene abnormalities.

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12 December 2020

FHIT expression in clear cell renal carcinomas: versatility of protein levels and correlation with survival

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12 December 2020

The FHIT gene 3p14.2 is abnormal in lung cancer.

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12 December 2020

Role of 5'-CpG island hypermethylation of the FHIT gene in cervical carcinoma

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12 December 2020

Characterization of a multiple epigenetic marker panel for lung cancer detection and risk assessment in plasma.

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12 December 2020

Genetic abnormalities in pancreatic cancer

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12 December 2020

Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit

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12 December 2020

Aberrant FHIT transcripts in squamous cell carcinoma of the uterine cervix

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12 December 2020

Potential gastrointestinal tumor suppressor locus at the 3p14.2 FRA3B site identified by homozygous deletions in tumor cell lines

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12 December 2020

Fhit interaction with ferredoxin reductase triggers generation of reactive oxygen species and apoptosis of cancer cells

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12 December 2020

Implication of mitochondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy

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12 December 2020

Significance of FHIT expression in chronic myelogenous leukemia

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12 December 2020

FHIT gene expression in human ovarian, endometrial, and cervical cancer cell lines

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12 December 2020

Cancer and the FRA3B/FHIT fragile locus: it's a HIT

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12 December 2020

Effect of FHIT gene replacement on growth, cell cycle and apoptosis in pancreatic cancer cells

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12 December 2020

Expressions of FHIT and cyclin D1/CDK4 in oral cancer and oral precancerous lesions

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12 December 2020

Molecular analysis of the fragile histidine triad (FHIT) tumor suppressor gene in vesical tumors of cattle with chronic enzootic hematuria (CEH).

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12 December 2020

[Correlation of FHIT expression to cell proliferation and metastasis of laryngeal squamous cell carcinoma]

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12 December 2020

FHIT loss of function in human primary breast cancer correlates with advanced stage of the disease

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12 December 2020

Tumor suppressor genes: does FHIT fit?

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12 December 2020

Deletion of the short arm of chromosome 3 in breast tumors

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12 December 2020

Genetic instability in colorectal cancers

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12 December 2020

Prognostic value of FHIT, CTNNB1, and MUC1 expression in non-small cell lung cancer

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12 December 2020

Hint, Fhit, and GalT: function, structure, evolution, and mechanism of three branches of the histidine triad superfamily of nucleotide hydrolases and transferases

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12 December 2020

Aberrant FHIT transcripts in acute myeloid leukaemia.

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12 December 2020

Aberration of the enzymatic activity of Fhit tumor suppressor protein enhances cancer cell death upon photodynamic therapy similarly to that driven by wild-type Fhit.

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12 December 2020

Decreased fragile histidine triad gene protein expression is associated with worse prognosis in oral squamous carcinoma

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12 December 2020

Mutator phenotype may be required for multistage carcinogenesis

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12 December 2020

Pattern of FHIT gene expression in normal and leukaemic cells

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12 December 2020

5' CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer

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12 December 2020

Aberrant FHIT mRNA transcripts are present in malignant and normal haematopoiesis, but absence of FHIT protein is restricted to leukaemia

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12 December 2020

Analysis of the FHIT gene and FRA3B region in sporadic breast cancer, preneoplastic lesions, and familial breast cancer probands

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12 December 2020

Absence or reduction of Fhit expression in most clear cell renal carcinomas.

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12 December 2020

Methylation status of fragile histidine triad (FHIT) gene and its clinical impact on prognosis of patients with multiple myeloma

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12 December 2020

Involvement of multiple loci on chromosome 3 in renal cell cancer development

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12 December 2020

Transforming growth factor beta 1 regulation of c-myc expression, pRB phosphorylation, and cell cycle progression in keratinocytes

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12 December 2020

The tumor-suppressor gene FHIT is involved in the regulation of apoptosis and in cell cycle control

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12 December 2020

Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins

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12 December 2020

Loss of fragile histidine triad gene expression is associated with progression of esophageal squamous cell carcinoma, but not with the patient's prognosis and smoking history

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12 December 2020

Understanding the mechanisms of FHIT inactivation in cervical cancer for biomarker development

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12 December 2020

Cytogenetic studies of 24 renal epithelial tumors with von Hippel-Lindau and fragile histidine triad protein expression correlation

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12 December 2020

Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats

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12 December 2020

The histidine triad superfamily of nucleotide-binding proteins

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12 December 2020

The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer

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12 December 2020

Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer

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12 December 2020

Loss of FHIT protein expression is related to high proliferation, low apoptosis and worse prognosis in non-small-cell lung cancer

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12 December 2020

The HIT protein family: a new family of proteins present in prokaryotes, yeast and mammals

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12 December 2020

Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes.

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12 December 2020

Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions

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12 December 2020

FHIT gene transcript alterations occur frequently in myeloproliferative and myelodysplastic diseases

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12 December 2020

Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein

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12 December 2020

Down-regulation of fragile histidine triad expression in prostate carcinoma

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12 December 2020

Identification of unstable sequences within the common fragile site at 3p14.2: implications for the mechanism of deletions within fragile histidine triad gene/common fragile site at 3p14.2 in tumors

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12 December 2020

The Fragile Histidine Triad gene and breast cancer.

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12 December 2020

Expression and simple, one-step purification of fragile histidine triad (Fhit) tumor suppressor mutant forms in Escherichia coli and their interaction with protoporphyrin IX.

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12 December 2020

Frequent breakpoints in the 3p14.2 fragile site, FRA3B, in pancreatic tumors

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12 December 2020

Molecular cloning of the canine fragile histidine triad (FHIT) gene and Fhit protein expression in canine peripheral blood mononuclear cells

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12 December 2020

MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family

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12 December 2020

Isolation and sequencing of a cDNA clone for a prolactin-inducible protein (PIP). Regulation of PIP gene expression in the human breast cancer cell line, T-47D

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12 December 2020

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers

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12 December 2020

The role of deletions at the FRA3B/FHIT locus in carcinogenesis.

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12 December 2020

Replacement of Fhit in cancer cells suppresses tumorigenicity

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12 December 2020

Loss of FHIT expression in acute lymphoblastic leukemia

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12 December 2020

Divergent evolution of the prolactin-inducible protein gene and related genes in the mouse genome

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12 December 2020

Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus

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12 December 2020

The tumor suppressor protein Fhit. A novel interaction with tubulin

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12 December 2020

Allelic loss determination in chronic lymphocytic leukemia by immunomagnetic bead sorting and microsatellite marker analysis

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12 December 2020

Two breakpoint clusters at fragile site FRA3B form phased nucleosomes

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12 December 2020

Preclinical assessment of FHIT gene replacement therapy in human leukemia using a chimeric adenovirus, Ad5/F35.

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12 December 2020

Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia

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12 December 2020

Wild-type but not mutant APC associates with the microtubule cytoskeleton.

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12 December 2020

FHIT gene alterations in head and neck squamous cell carcinomas

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12 December 2020

Acute lymphoblastic leukaemia.

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12 December 2020

Research directions in epithelial ovarian cancer

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12 December 2020

Differential gene expression in nickel(II)-treated normal rat kidney cells

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12 December 2020

Loss of FHIT expression in gastric carcinoma.

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12 December 2020

DNA methylation and loss of protein expression in esophageal squamous cell carcinogenesis of high-risk area.

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12 December 2020

Fhit and CHK1 have opposing effects on homologous recombination repair

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12 December 2020

Comparative genomic mapping of the bovine Fragile Histidine Triad (FHIT) tumour suppressor gene: characterization of a 2 Mb BAC contig covering the locus, complete annotation of the gene, analysis of cDNA and of physiological expression profiles.

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12 December 2020

Molecular aspects of carcinogenesis in pancreatic cancer.

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12 December 2020

Fhit is a physiological target of the protein kinase Src

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12 December 2020

Decreased or altered expression of the FHIT gene in human leukemias

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12 December 2020

[Combined modality treatment of lung cancer: present and future]

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12 December 2020

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

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12 December 2020

10.1007/S00432-009-0751-9

Identifiers

DOI

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21 June 2017

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