(Q30421643)

English

Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Small-molecule structure correctors target abnormal protein structure and function: structure corrector rescue of apolipoprotein E4-associated neuropathology (English)

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

protein structure

0 references

author name string

Robert W Mahley

1

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Yadong Huang

2

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

language of work or name

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publication date

5 October 2012

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Europe PubMed Central

PMC publication ID

17 August 2017

Journal of Medicinal Chemistry

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Europe PubMed Central

PMC publication ID

17 August 2017

55

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

21

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

8997-9008

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

Alzheimer mechanisms and therapeutic strategies

1 reference

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Haploinsufficiency of human APOE reduces amyloid deposition in a mouse model of amyloid-β amyloidosis

1 reference

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Small molecule structure correctors abolish detrimental effects of apolipoprotein E4 in cultured neurons.

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Human apoE isoforms differentially regulate brain amyloid-β peptide clearance

1 reference

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Structure-dependent impairment of intracellular apolipoprotein E4 trafficking and its detrimental effects are rescued by small-molecule structure correctors

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Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening

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Abeta-independent roles of apolipoprotein E4 in the pathogenesis of Alzheimer's disease

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Influence of cell background on pharmacological rescue of mutant CFTR.

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1 reference

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The role of apolipoprotein E in Alzheimer's disease

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Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

Apolipoprotein E modulates clearance of apoptotic bodies in vitro and in vivo, resulting in a systemic proinflammatory state in apolipoprotein E-deficient mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

Six-month recovery from mild to moderate Traumatic Brain Injury: the role of APOE-epsilon4 allele.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

Apolipoprotein E controls the risk and age at onset of Parkinson disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

Lower levels of N-acetylaspartate in multiple sclerosis patients with the apolipoprotein E epsilon4 allele

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

APOE genotype influences acquisition and recall following traumatic brain injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

Parkinson's disease and apolipoprotein E: possible association with dementia but not age at onset

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

Apolipoprotein E epsilon 4 is associated with rapid progression of multiple sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4904786

26 November 2018

N-octyl-beta-valienamine up-regulates activity of F213I mutant beta-glucosidase in cultured cells: a potential chemical chaperone therapy for Gaucher disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical chaperones improve transport and enhance stability of mutant alpha-glucosidases in glycogen storage disease type II

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ApoE genotype and survival from intracerebral haemorrhage

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Fabry's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of apolipoprotein E structure by domain interaction: differences in lipid-bound and lipid-free forms

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Accelerated transport and maturation of lysosomal α–galactosidase A in Fabry lymphoblasts by an enzyme inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell-Based Screening of Active-Site Specific Chaperone for the Treatment of Fabry Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacological rescue of mutant p53 conformation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/23013167

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JM3008618

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

17 August 2017

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