(Q40523596)

English

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc

scientific article published on 20 August 2004

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scholarly article

1 reference

Europe PubMed Central

21 September 2017

Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc (English)

1 reference

Europe PubMed Central

21 September 2017

phosphorylation

1 reference

based on heuristic

inferred from title

author name string

Faith M Harris

1

1 reference

Europe PubMed Central

21 September 2017

Walter J Brecht

2

1 reference

Europe PubMed Central

21 September 2017

Qin Xu

3

1 reference

Europe PubMed Central

21 September 2017

Robert W Mahley

4

1 reference

Europe PubMed Central

21 September 2017

Yadong Huang

5

1 reference

Europe PubMed Central

21 September 2017

language of work or name

0 references

publication date

20 August 2004

1 reference

Europe PubMed Central

21 September 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

21 September 2017

279

1 reference

Europe PubMed Central

21 September 2017

44795-44801

1 reference

Europe PubMed Central

21 September 2017

43

1 reference

Europe PubMed Central

21 September 2017

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

The molecular pathology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E affects the rate of Alzheimer disease expression: beta-amyloid burden is a secondary consequence dependent on APOE genotype and duration of disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E: far more than a lipid transport protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E: diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E receptors: linking brain development and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Truncated apoE forms tangle-like structures in a neuronal cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Neurofibrillary tangles and β-amyloid deposits in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Neurodegenerative tauopathies

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

The multifaceted roles of glycogen synthase kinase 3beta in cellular signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Regulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

A decade of CDK5.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Activation of neuronal extracellular receptor kinase (ERK) in Alzheimer disease links oxidative stress to abnormal phosphorylation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Tau phosphorylation in transgenic mice expressing glycogen synthase kinase-3beta transgenes.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Phosphorylation of tau by fyn: implications for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Zinc induces a Src family kinase-mediated up-regulation of NMDA receptor activity and excitotoxicity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Up-regulation of phosphorylated/activated p70 S6 kinase and its relationship to neurofibrillary pathology in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Effect of zinc on calmodulin-stimulated protein kinase II and protein phosphorylation in rat cerebral cortex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

p42 mitogen-activated protein kinase in brain: prominent localization in neuronal cell bodies and dendrites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Structure, microtubule interactions, and phosphorylation of tau protein

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Up-regulation of mitogen-activated protein kinases ERK1/2 and MEK1/2 is associated with the progression of neurofibrillary degeneration in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Stress-induced tau phosphorylation in mouse strains with different brain Erk 1 + 2 immunoreactivity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

p42 map kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1Implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Extracellular signal-regulated kinase (MAP kinase) immunoreactivity in the rhesus monkey brain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

The inhibition of single N-methyl-D-aspartate-activated channels by zinc ions on cultured rat neurones

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

The actions of synaptically released zinc at hippocampal mossy fiber synapses.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Zn(2+): a novel ionic mediator of neural injury in brain disease.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Zinc neurotoxicity in cortical cell culture

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Possible role of zinc in the selective degeneration of dentate hilar neurons after cerebral ischemia in the adult rat.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Copper, iron and zinc in Alzheimer's disease senile plaques.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Rapid induction of Alzheimer A beta amyloid formation by zinc.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Release of endogenous Zn2+ from brain tissue during activity.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Stimulation-induced uptake and release of zinc in hippocampal slices

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M408127200

21 January 2018

Identifiers

10.1074/JBC.M408127200

1 reference

Europe PubMed Central

21 September 2017

1 reference

Europe PubMed Central

21 September 2017

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