(Q28265290)

12 December 2020

Astrocytes down-regulate neuronal beta-amyloid precursor protein expression and modify its processing in an apolipoprotein E isoform-specific manner.

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12 December 2020

Regionally specific neuronal expression of human APOE gene in transgenic mice.

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12 December 2020

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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12 December 2020

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms

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12 December 2020

Differential distribution of apolipoprotein E isoforms in human plasma lipoproteins

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12 December 2020

Apolipoprotein E is localized to the cytoplasm of human cortical neurons: a light and electron microscopic study

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12 December 2020

Alzheimer Disease in the US Population

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12 December 2020

Denervated sheath cells secrete a new protein after nerve injury

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12 December 2020

Expression of apolipoprotein E during nerve degeneration and regeneration

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12 December 2020

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Expression of apolipoprotein E in normal and diverse neurodegenerative disease brain.

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12 December 2020

Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.

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12 December 2020

ApoE synthesis in human neuroblastoma cells.

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12 December 2020

Expression of the apolipoprotein E gene in the skin is controlled by a unique downstream enhancer

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12 December 2020

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease

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12 December 2020

Expression of human apolipoprotein E4 in neurons causes hyperphosphorylation of protein tau in the brains of transgenic mice

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12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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12 December 2020

Acceleration of Alzheimer's fibril formation by apolipoprotein E in vitro

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12 December 2020

Lipoprotein uptake by neuronal growth cones in vitro

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12 December 2020

Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

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12 December 2020

Apolipoprotein E: from atherosclerosis to Alzheimer's disease and beyond

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12 December 2020

Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth

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12 December 2020

Glial fibrillary acidic protein-apolipoprotein E (apoE) transgenic mice: astrocyte-specific expression and differing biological effects of astrocyte-secreted apoE3 and apoE4 lipoproteins.

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12 December 2020

Glial gene expression during aging in rat striatum and in long-term responses to 6-OHDA lesions

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12 December 2020

Apolipoprotein E receptors: linking brain development and Alzheimer's disease

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12 December 2020

Apolipoprotein E: impact of cytoskeletal stability in neurons and the relationship to Alzheimer's disease.

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12 December 2020

Oxidative protein damage in cells engaged in beta-amyloidosis is related to apoE genotype.

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12 December 2020

Two distal downstream enhancers direct expression of the human apolipoprotein E gene to astrocytes in the brain.

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12 December 2020

Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology

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12 December 2020

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

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12 December 2020

Quantitation of apoE domains in Alzheimer disease brain suggests a role for apoE in Abeta aggregation

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12 December 2020

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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12 December 2020

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro

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12 December 2020

Expression of human apolipoprotein E3 or E4 in the brains of Apoe-/- mice: isoform-specific effects on neurodegeneration.

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12 December 2020

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

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12 December 2020

Increased expression of neuronal apolipoprotein E in human brain with cerebral infarction.

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12 December 2020

Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord

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12 December 2020

Apolipoprotein E: structure-function relationships

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12 December 2020

A thrombin cleavage fragment of apolipoprotein E exhibits isoform-specific neurotoxicity.

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12 December 2020

Apolipoprotein E and cognitive performance

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12 December 2020

Synthesis of apolipoprotein E (ApoE) mRNA by human neuronal-type SK N SH-SY 5Y cells and its regulation by nerve growth factor and ApoE

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12 December 2020

Identification of the disulfide-linked homodimer of apolipoprotein E3 in plasma. Impact on receptor binding activity

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12 December 2020

Truncated apoE forms tangle-like structures in a neuronal cell line

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12 December 2020

Abnormal in vivo metabolism of apolipoprotein E4 in humans

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12 December 2020

Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.

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12 December 2020

Hyper-expression of human apolipoprotein E4 in astroglia and neurons does not enhance amyloid deposition in transgenic mice.

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12 December 2020

The switch of tau protein to an Alzheimer-like state includes the phosphorylation of two serine-proline motifs upstream of the microtubule binding region

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12 December 2020

Apolipoprotein E affects the amount, form, and anatomical distribution of amyloid beta-peptide deposition in homozygous APP(V717F) transgenic mice.

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12 December 2020

Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during aging.

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12 December 2020

Human apolipoprotein E. The complete amino acid sequence

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12 December 2020

Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice

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12 December 2020

Apolipoprotein E modulates Alzheimer's Abeta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner

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12 December 2020

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

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12 December 2020

Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype

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12 December 2020

Injury-induced synthesis and release of apolipoprotein E and clusterin from rat neural cells.

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12 December 2020

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system

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12 December 2020

Beta-amyloid induces neuronal apoptosis via a mechanism that involves the c-Jun N-terminal kinase pathway and the induction of Fas ligand.

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12 December 2020

Genetics of the apolipoprotein E system in man

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12 December 2020

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

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12 December 2020

Biochemical analysis of cell-derived apoE3 particles active in stimulating neurite outgrowth

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12 December 2020

Astroglial regulation of apolipoprotein E expression in neuronal cells. Implications for Alzheimer's disease

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12 December 2020

Duplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue

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12 December 2020

Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein

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12 December 2020

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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12 December 2020

Androgens protect against apolipoprotein E4-induced cognitive deficits

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12 December 2020

Specific regional transcription of apolipoprotein E in human brain neurons

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12 December 2020

Amyloid beta-protein, APOE genotype and head injury

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12 December 2020

Aggregated amyloid-beta protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction.

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12 December 2020

A minimally lipidated form of cell-derived apolipoprotein E exhibits isoform-specific stimulation of neurite outgrowth in the absence of exogenous lipids or lipoproteins

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12 December 2020

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

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12 December 2020

Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms

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12 December 2020

Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease

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12 December 2020

Apolipoprotein E: far more than a lipid transport protein

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12 December 2020

Synthesis and processing of apolipoprotein E in human brain cultures

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12 December 2020

Neurodegeneration in the central nervous system of apoE-deficient mice

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12 December 2020

Apolipoprotein Eepsilon4 modifies Alzheimer's disease onset in an E280A PS1 kindred.

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12 December 2020

The role of apolipoprotein E in the nervous system.

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12 December 2020

Neurons of the human frontal cortex display apolipoprotein E immunoreactivity: implications for Alzheimer's disease.

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12 December 2020

Regulation of apolipoprotein E secretion in rat primary hippocampal astrocyte cultures

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12 December 2020

Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112.

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12 December 2020

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease.

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12 December 2020

A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve

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12 December 2020

A specific 37,000-dalton protein that accumulates in regenerating but not in nonregenerating mammalian nerves.

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12 December 2020

Clearing the brain's amyloid cobwebs

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12 December 2020

Onset of apoprotein E secretion during differentiation of mouse bone marrow-derived mononuclear phagocytes

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12 December 2020

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line

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12 December 2020

Apoprotein (E–A-II) complex of human plasma lipoproteins. I. Characterization of this mixed disulfide and its identification in a high density lipoprotein subfraction

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12 December 2020

Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease.

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12 December 2020

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

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12 December 2020

The intracellular fate of apolipoprotein E is tau dependent and apoe allele-specific.

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12 December 2020

ApoE protects cortical neurones against neurotoxicity induced by the non-fibrillar C-terminal domain of the amyloid-beta peptide.

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12 December 2020

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

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12 December 2020

Human apolipoprotein E isoprotein subclasses are genetically determined

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12 December 2020

Apolipoprotein E alleles as risk factors in Alzheimer's disease

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12 December 2020

Isoform-specific effect of apolipoprotein E on cell survival and beta-amyloid-induced toxicity in rat hippocampal pyramidal neuronal cultures.

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12 December 2020

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

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12 December 2020

Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

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12 December 2020

Structural basis for receptor binding heterogeneity of apolipoprotein E from type III hyperlipoproteinemic subjects

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12 December 2020

Genetic control of human apolipoprotein E polymorphism: comparison of one- and two-dimensional techniques of isoprotein analysis

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12 December 2020

Human apolipoprotein E3 in aqueous solution. II. Properties of the amino- and carboxyl-terminal domains.

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12 December 2020

Human apolipoprotein E: the Alzheimer's disease connection.

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12 December 2020

Tau proteins of Alzheimer paired helical filaments: abnormal phosphorylation of all six brain isoforms

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12 December 2020

Caspase-2 mediates neuronal cell death induced by beta-amyloid

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12 December 2020

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

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12 December 2020

Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins

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12 December 2020

Sialylated human apolipoprotein E (apoEs) is preferentially associated with neuron-enriched cultures from APOE transgenic mice.

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12 December 2020

Structure of tau protein and assembly into paired helical filaments

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12 December 2020

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E

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12 December 2020

Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain

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12 December 2020

Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease.

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12 December 2020

Synthesis and regulation of apolipoprotein E during the differentiation of human neuronal precursor NT2/D1 cells into postmitotic neurons

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12 December 2020

Apoprotein (E–A-II) complex of human plasma lipoproteins. II. Receptor binding activity of a high density lipoprotein subfraction modulated by the apo(E–A-II) complex

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12 December 2020

Introduction of human apolipoprotein E4 "domain interaction" into mouse apolipoprotein E

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12 December 2020

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets

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12 December 2020

Neuron-specific apolipoprotein e4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice.

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12 December 2020

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

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12 December 2020

Unique lipoproteins secreted by primary astrocytes from wild type, apoE (-/-), and human apoE transgenic mice.

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12 December 2020

Amyloid beta40/42 clearance across the blood-brain barrier following intra-ventricular injections in wild-type, apoE knock-out and human apoE3 or E4 expressing transgenic mice.

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12 December 2020

Expression of specific sheath cell proteins during peripheral nerve growth and regeneration in mammals

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12 December 2020

Familial Alzheimer disease among Caribbean Hispanics: a reexamination of its association with APOE.

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12 December 2020

Alzheimer's disease: an overview of current and emerging therapeutic strategies

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12 December 2020

Apolipoprotein E expression by neurons surviving excitotoxic stress

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12 December 2020

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

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12 December 2020

Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta using physiological concentrations.

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12 December 2020

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

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12 December 2020

Beta-amyloid peptide interacts specifically with the carboxy-terminal domain of human apolipoprotein E: relevance to Alzheimer's disease.

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12 December 2020

Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments

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12 December 2020

Isoform-specific effects of apolipoproteins E2, E3, and E4 on cerebral capillary sequestration and blood-brain barrier transport of circulating Alzheimer's amyloid beta.

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12 December 2020

Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein.

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12 December 2020

Apolipoprotein E4 allele as a predictor of cholinergic deficits and treatment outcome in Alzheimer disease

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization

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12 December 2020

Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide

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12 December 2020

Neurotoxicity of the 22 kDa thrombin-cleavage fragment of apolipoprotein E and related synthetic peptides is receptor-mediated

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12 December 2020

Regulation of apolipoprotein E gene expression after injury of the rat sciatic nerve

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12 December 2020

The APOE-epsilon4 allele and the risk of Alzheimer disease among African Americans, whites, and Hispanics

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12 December 2020

Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro

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12 December 2020

Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3

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12 December 2020

beta-Amyloid-induced neuronal apoptosis requires c-Jun N-terminal kinase activation.

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12 December 2020

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity.

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12 December 2020

Tau is essential to beta -amyloid-induced neurotoxicity

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12 December 2020

Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid

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12 December 2020

Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease

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12 December 2020

Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.

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12 December 2020

Apoptosis is induced by beta-amyloid in cultured central nervous system neurons

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12 December 2020

Apolipoprotein E4 potentiates amyloid beta peptide-induced lysosomal leakage and apoptosis in neuronal cells

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12 December 2020

Isoform-specific binding of apolipoprotein E to beta-amyloid

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12 December 2020

Human apolipoprotein E3 in aqueous solution. I. Evidence for two structural domains

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12 December 2020

Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease.

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12 December 2020

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

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12 December 2020

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

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12 December 2020