(Q30478048)

2 September 2017

Protein complex formation by acetylcholinesterase and the neurotoxin fasciculin-2 appears to involve an induced-fit mechanism (English)

1 reference

2 September 2017

2

J Andrew McCammon

1 reference

2 September 2017

Jennifer M Bui

1

1 reference

PMC publication ID

1591298

2 September 2017

language of work or name

English

0 references

publication date

4 October 2006

1 reference

Proceedings of the National Academy of Sciences of the United States of America

2 September 2017

1 reference

2 September 2017

103

1 reference

2 September 2017

42

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2 September 2017

15451-15456

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Molecular dynamics: survey of methods for simulating the activity of proteins

2 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Application of a Theory of Enzyme Specificity to Protein Synthesis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Conformational transitions in protein-protein association: binding of fasciculin-2 to acetylcholinesterase

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Coarse-grained models for proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Nonlinear elasticity, proteinquakes, and the energy landscapes of functional transitions in proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

A Three-Dimensional Model of the Myoglobin Molecule Obtained by X-Ray Analysis

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Nanosecond dynamics of the mouse acetylcholinesterase cys69-cys96 omega loop

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Electrostatics of nanosystems: application to microtubules and the ribosome

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

The energy landscape theory of protein folding: insights into folding mechanisms and scenarios

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Folding and binding cascades: shifts in energy landscapes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Theory of protein folding: the energy landscape perspective

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Molecular switch in signal transduction: reaction paths of the conformational changes in ras p21.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Calculation of pathways for the conformational transition between the GTP- and GDP-bound states of the Ha-ras-p21 protein: calculations with explicit solvent simulations and comparison with calculations in vacuum.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Reduced surface: an efficient way to compute molecular surfaces

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Site of fasciculin interaction with acetylcholinesterase

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Allosteric Control of Acetylcholinesterase Catalysis by Fasciculin

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

The Energy Landscapes and Motions of Proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Dynamics of activated processes in globular proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Acetylcholinesterase: enhanced fluctuations and alternative routes to the active site in the complex with fasciculin-2.

14 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605355103

Simple energy landscape model for the kinetics of functional transitions in proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605355103

Mechanism of acetylcholinesterase inhibition by fasciculin: a 5-ns molecular dynamics simulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605355103

Open "back door" in a molecular dynamics simulation of acetylcholinesterase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605355103

Inhibitors of different structure induce distinguishing conformations in the omega loop, Cys69-Cys96, of mouse acetylcholinesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605355103

Simulation of charge-mutant acetylcholinesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605355103

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605355103

Molecular dynamics with coupling to an external bath

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0605355103

Acetylcholinesterase: pivotal roles of its long omega loop (Cys69-Cys96) in regulating substrate binding

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1591298

Fasciculin 2 Binds to the Peripheral Site on Acetylcholinesterase and Inhibits Substrate Hydrolysis by Slowing a Step Involving Proton Transfer during Enzyme Acylation

26 November 2018

1 reference

12 December 2020

Acetylthiocholine binds to asp74 at the peripheral site of human acetylcholinesterase as the first step in the catalytic pathway

1 reference

12 December 2020

New insights into the mechanism of protein-protein association

1 reference

12 December 2020

Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks

1 reference

12 December 2020

Crystals of fasciculin 2 from green mamba snake venom. Preparation and preliminary x-ray analysis

1 reference

12 December 2020

Interaction of cyclosporin A with an Fab fragment or cyclophilin. Affinity measurements and time-dependent changes in binding

1 reference

12 December 2020

Identifiers

DOI

10.1073/PNAS.0605355103

1 reference

2 September 2017

0 references

1 reference

PMC publication ID

1591298

2 September 2017

PubMed publication ID

17021015

1 reference

PMC publication ID

1591298