(Q30500118)

19 October 2017

Architecture of a full-length retroviral integrase monomer and dimer, revealed by small angle X-ray scattering and chemical cross-linking (English)

1 reference

X-ray scattering techniques

19 October 2017

1 reference

8

Anna Marie Skalka

1 reference

19 October 2017

Ravi S Bojja

1

1 reference

19 October 2017

Mark D Andrake

2

1 reference

19 October 2017

Steven Weigand

3

1 reference

19 October 2017

George Merkel

4

1 reference

19 October 2017

Olya Yarychkivska

5

1 reference

19 October 2017

Adam Henderson

6

1 reference

19 October 2017

Marissa Kummerling

7

1 reference

19 October 2017

language of work or name

English

0 references

publication date

15 March 2011

1 reference

Journal of Biological Chemistry

19 October 2017

1 reference

19 October 2017

286

1 reference

19 October 2017

19

1 reference

19 October 2017

17047-17059

1 reference

The mechanism of retroviral integration from X-ray structures of its key intermediates

19 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Solution structures of DNA-bound gyrase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Protein binding hot spots and the residue-residue pairing preference: a water exclusion perspective

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

The HADDOCK web server for data-driven biomolecular docking

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Structural properties of HIV integrase. Lens epithelium-derived growth factor oligomers

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Retroviral intasome assembly and inhibition of DNA strand transfer

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Piecing together the structure of retroviral integrase, an important target in AIDS therapy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Characterization and structural analysis of HIV-1 integrase conservation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

MassMatrix: a database search program for rapid characterization of proteins and peptides from tandem mass spectrometry data

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Shape shifting leads to small-molecule allosteric drug discovery

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Subunit-specific protein footprinting reveals significant structural rearrangements and a role for N-terminal Lys-14 of HIV-1 Integrase during viral DNA binding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Retroviral DNA integration: reaction pathway and critical intermediates

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

HIV-1 integrase crosslinked oligomers are active in vitro

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Mapping the epitope of an inhibitory monoclonal antibody to the C-terminal DNA-binding domain of HIV-1 integrase.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Using situs for flexible and rigid-body fitting of multiresolution single-molecule data

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Human immunodeficiency virus type 1 integrase: arrangement of protein domains in active cDNA complexes

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Determination of domain structure of proteins from X-ray solution scattering

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

An inhibitory monoclonal antibody binds at the turn of the helix-turn-helix motif in the N-terminal domain of HIV-1 integrase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Oligomeric states of the HIV-1 integrase as measured by time-resolved fluorescence anisotropy

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Refined solution structure of the C-terminal DNA-binding domain of human immunovirus-1 integrase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Restoring low resolution structure of biological macromolecules from solution scattering using simulated annealing

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

The atomic structure of protein-protein recognition sites

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor: high level of similarity of the active site with other viral integrases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

The crystal structure of the hyperthermophile chromosomal protein Sso7d bound to DNA

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Three new structures of the core domain of HIV-1 integrase: an active site that binds magnesium

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Solution structure of the N-terminal zinc binding domain of HIV-1 integrase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Binding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle by targeting human immunodeficiency virus type 1 integrase.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Zinc folds the N-terminal domain of HIV-1 integrase, promotes multimerization, and enhances catalytic activity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

The catalytic domain of avian sarcoma virus integrase: conformation of the active-site residues in the presence of divalent cations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Identification of discrete functional domains of HIV-1 integrase and their organization within an active multimeric complex

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Complementation between HIV integrase proteins mutated in different domains

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Crystal structure of the catalytic domain of HIV-1 integrase: similarity to other polynucleotidyl transferases

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Solution structure of the DNA binding domain of HIV-1 integrase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Catalytic domain of human immunodeficiency virus type 1 integrase: identification of a soluble mutant by systematic replacement of hydrophobic residues

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

High-resolution structure of the catalytic domain of avian sarcoma virus integrase

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

The DNA-binding domain of HIV-1 integrase has an SH3-like fold

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

The avian retroviral IN protein is both necessary and sufficient for integrative recombination in vitro.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Retroviral integrase functions as a multimer and can turn over catalytically

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3089549

Characterization of the self association of Avian sarcoma virus integrase by analytical ultracentrifugation

20 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.212571

Zn2+ promotes the self-association of human immunodeficiency virus type-1 integrase in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.212571

Functional oligomeric state of avian sarcoma virus integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.212571

Modeling HIV-1 integrase complexes based on their hydrodynamic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.212571

Four-tiered pi interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.212571

Multimerization determinants reside in both the catalytic core and C terminus of avian sarcoma virus integrase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.212571

21 January 2018

1 reference

12 December 2020

Mutations in the C‐terminal domain of ALSV (Avian Leukemia and Sarcoma Viruses) integrase alter the concerted DNA integration process in vitro

1 reference

12 December 2020

An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer

1 reference

12 December 2020

A soluble active mutant of HIV-1 integrase: involvement of both the core and carboxyl-terminal domains in multimerization

1 reference

12 December 2020

The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: a three-helix bundle stabilized by zinc

1 reference

12 December 2020

Model of full-length HIV-1 integrase complexed with viral DNA as template for anti-HIV drug design.

1 reference

12 December 2020

Identifiers

DOI

10.1074/JBC.M110.212571

1 reference

19 October 2017

1 reference

19 October 2017

PubMed publication ID

21454648

1 reference