(Q30612936)

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Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents

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Europe PubMed Central

PMC publication ID

19 October 2017

Selective blockade of the hydrolysis of the endocannabinoid 2-arachidonoylglycerol impairs learning and memory performance while producing antinociceptive activity in rodents (English)

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19 October 2017

endocannabinoids

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glyceryl 2-arachidonate

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23

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21

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Alexey Rak

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Europe PubMed Central

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19 October 2017

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Guy Griebel

1

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19 October 2017

Philippe Pichat

2

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19 October 2017

Sandra Beeské

3

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19 October 2017

Thibaud Leroy

4

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19 October 2017

Nicolas Redon

5

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19 October 2017

Agnès Jacquet

6

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19 October 2017

Dominique Françon

7

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19 October 2017

Lionel Bert

8

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19 October 2017

Luc Even

9

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19 October 2017

Mati Lopez-Grancha

10

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19 October 2017

Tatiana Tolstykh

11

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19 October 2017

Fangxian Sun

12

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19 October 2017

Qunyan Yu

13

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19 October 2017

Scott Brittain

14

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19 October 2017

Heike Arlt

15

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19 October 2017

Timothy He

16

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19 October 2017

Bailin Zhang

17

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19 October 2017

Dmitri Wiederschain

18

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19 October 2017

Thomas Bertrand

19

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19 October 2017

Jacques Houtmann

20

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19 October 2017

François Vallée

22

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19 October 2017

Franck Augé

24

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19 October 2017

Véronique Menet

25

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19 October 2017

Olivier E Bergis

26

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19 October 2017

Pascal George

27

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19 October 2017

Patrick Avenet

28

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19 October 2017

Vincent Mikol

29

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19 October 2017

Michel Didier

30

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19 October 2017

Johanna Escoubet

31

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19 October 2017

language of work or name

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publication date

6 January 2015

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19 October 2017

Scientific Reports

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19 October 2017

5

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19 October 2017

7642

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Europe PubMed Central

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19 October 2017

copyright license

Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

6 January 2015

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April 2022 Public Data File from Crossref

copyright status

0 references

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Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy

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In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29: antinociceptive activity without cannabimimetic side effects.

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Latest advances in the discovery of fatty acid amide hydrolase inhibitors

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Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy

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Therapeutic potential of monoacylglycerol lipase inhibitors

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Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice

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"Redundancy" of endocannabinoid inactivation: new challenges and opportunities for pain control

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Monoacylglycerol lipase - a target for drug development?

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Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice

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28 July 2018

Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats

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Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

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The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

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28 July 2018

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

1 reference

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28 July 2018

Discovery of potent and reversible monoacylglycerol lipase inhibitors.

1 reference

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28 July 2018

Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism

1 reference

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28 July 2018

The endocannabinoid system as a target for novel anxiolytic and antidepressant drugs

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28 July 2018

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain

1 reference

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From endocannabinoid profiling to 'endocannabinoid therapeutics'.

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28 July 2018

Central side-effects of therapies based on CB1 cannabinoid receptor agonists and antagonists: focus on anxiety and depression

1 reference

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An introduction to the endocannabinoid system: from the early to the latest concepts

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28 July 2018

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

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Targeting the endocannabinoid system: to enhance or reduce?

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Short- and long-term plasticity of the endocannabinoid system in neuropsychiatric and neurological disorders

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Endocannabinoid enhancement protects against kainic acid-induced seizures and associated brain damage

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Endocannabinoids and the regulation of their levels in health and disease

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Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review).

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Endocannabinoid mechanisms of pain modulation

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Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study

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The endocannabinoid system and its therapeutic exploitation

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The pharmacology of cannabinoid receptors and their ligands: an overview

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Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain

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Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia

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Anandamide hydrolysis: a new target for anti-anxiety drugs?

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Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain

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Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

1 reference

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Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

1 reference

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Differential role of anandamide and 2-arachidonoylglycerol in memory and anxiety-like responses

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Repeated low-dose administration of the monoacylglycerol lipase inhibitor JZL184 retains cannabinoid receptor type 1-mediated antinociceptive and gastroprotective effects

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Structural basis for human monoglyceride lipase inhibition

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Monoacylglycerol lipase activity is a critical modulator of the tone and integrity of the endocannabinoid system

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Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity

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Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.

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Generation of 2-arachidonoylglycerol, an endogenous cannabinoid receptor ligand, in picrotoxinin-administered rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/25560837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study

1 reference

https://pubmed.ncbi.nlm.nih.gov/25560837

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25560837

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/25560837

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/SREP07642

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

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PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

19 October 2017

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