(Q30670705)

English

Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and in

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Europe PubMed Central

PMC publication ID

14 October 2017

Diaryl- and triaryl-pyrrole derivatives: inhibitors of the MDM2-p53 and MDMX-p53 protein-protein interactions†Electronic supplementary information (ESI) available: Experimental details for compound synthesis, analytical data for all compounds and in (English)

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

protein-protein interaction

1 reference

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inferred from title

14

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John Lunec

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Europe PubMed Central

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14 October 2017

author name string

Tim J Blackburn

1

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Europe PubMed Central

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14 October 2017

Shafiq Ahmed

2

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Europe PubMed Central

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14 October 2017

Christopher R Coxon

3

1 reference

Europe PubMed Central

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14 October 2017

Junfeng Liu

4

1 reference

Europe PubMed Central

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14 October 2017

Xiaohong Lu

5

1 reference

Europe PubMed Central

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14 October 2017

Bernard T Golding

6

1 reference

Europe PubMed Central

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14 October 2017

Roger J Griffin

7

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Europe PubMed Central

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14 October 2017

Claire Hutton

8

1 reference

Europe PubMed Central

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14 October 2017

David R Newell

9

1 reference

Europe PubMed Central

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14 October 2017

Stephen Ojo

10

1 reference

Europe PubMed Central

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14 October 2017

Anna F Watson

11

1 reference

Europe PubMed Central

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14 October 2017

Andrey Zaytzev

12

1 reference

Europe PubMed Central

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14 October 2017

Yan Zhao

13

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Europe PubMed Central

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14 October 2017

Ian R Hardcastle

15

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14 October 2017

language of work or name

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publication date

29 July 2013

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14 October 2017

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Europe PubMed Central

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14 October 2017

4

1 reference

Europe PubMed Central

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14 October 2017

9

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

1297-1304

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

Deconstruction of a Nutlin: Dissecting the Binding Determinants of a Potent Protein–Protein Interaction Inhibitor

1 reference

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20 June 2018

Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development

1 reference

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20 June 2018

Diastereomeric spirooxindoles as highly potent and efficacious MDM2 inhibitors

1 reference

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20 June 2018

Mdm2 and MdmX inhibitors for the treatment of cancer: a patent review (2011-present).

1 reference

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20 June 2018

MDM4 is a key therapeutic target in cutaneous melanoma

1 reference

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20 June 2018

Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Structure-based design of novel inhibitors of the MDM2-p53 interaction

1 reference

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20 June 2018

Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties

1 reference

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Overview of the CCP4 suite and current developments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Features and development of Coot

1 reference

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20 June 2018

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Identification and characterization of the first small molecule inhibitor of MDMX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

MDMX: from bench to bedside

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Small-molecule inhibitors of the MDM2-p53 protein-protein interaction based on an isoindolinone scaffold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Mdm4 and Mdm2 cooperate to inhibit p53 activity in proliferating and quiescent cells in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Microwave-Assisted Paal−Knorr Reaction. A Rapid Approach to Substituted Pyrroles and Furans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Live or let die: the cell's response to p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

MDM2 interacts with MDMX through their RING finger domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Mdm2 association with p53 targets its ubiquitination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Regulation of p53 stability by Mdm2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Mdm2 promotes the rapid degradation of p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

p53, the cellular gatekeeper for growth and division

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

1 reference

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20 June 2018

MDMX: a novel p53-binding protein with some functional properties of MDM2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3777193

20 June 2018

Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery.

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00161J

21 January 2018

Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00161J

21 January 2018

1,5-Diphenylpyrrole derivatives as antimycobacterial agents. Probing the influence on antimycobacterial activity of lipophilic substituents at the phenyl rings.

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00161J

21 January 2018

Tetrapropylammonium Perruthenate, Pr4N+RuO4 -, TPAP: A Catalytic Oxidant for Organic Synthesis

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00161J

21 January 2018

Analysis of chemical shift changes reveals the binding modes of isoindolinone inhibitors of the MDM2-p53 interaction

1 reference

https://api.crossref.org/works/10.1039%2FC3MD00161J

21 January 2018

Discovery, synthesis, and biological evaluation of orally active pyrrolidone derivatives as novel inhibitors of p53-MDM2 protein-protein interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/24078862

12 December 2020

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10.1039/C3MD00161J

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 October 2017

PubMed publication ID

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Europe PubMed Central

PMC publication ID

14 October 2017

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