(Q30805841)

English

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy.

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27578006%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Affinity of Tau antibodies for solubilized pathological Tau species but not their immunogen or insoluble Tau aggregates predicts in vivo and ex vivo efficacy (English)

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22 March 2020

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22 March 2020

Einar M Sigurdsson

12

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22 March 2020

author name string

Yan Lin

2

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22 March 2020

Hameetha B Rajamohamedsait

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22 March 2020

Dov B Shamir

4

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22 March 2020

Senthilkumar Krishnaswamy

5

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22 March 2020

Wajitha J Rajamohamedsait

6

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22 March 2020

Suhail Rasool

7

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22 March 2020

Veronica Gonzalez

8

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22 March 2020

Josien Levenga

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22 March 2020

Jiaping Gu

10

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22 March 2020

Charles Hoeffer

11

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22 March 2020

publication date

30 August 2016

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22 March 2020

Molecular Neurodegeneration

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22 March 2020

11

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22 March 2020

1

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22 March 2020

62

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22 March 2020

https://scigraph.springernature.com/pub.10.1186/s13024-016-0126-z

0 references

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Tau immunotherapy for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Antibody-derived in vivo imaging of tau pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Disruption of polyubiquitin gene Ubb causes dysregulation of neural stem cell differentiation with premature gliogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Prion-like mechanisms in the pathogenesis of tauopathies and synucleinopathies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Transneuronal propagation of mutant huntingtin contributes to non-cell autonomous pathology in neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Harnessing the immune system for treatment and detection of tau pathology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Reduced glucocerebrosidase is associated with increased α-synuclein in sporadic Parkinson's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Tau pathology induces loss of GABAergic interneurons leading to altered synaptic plasticity and behavioral impairments.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Tau passive immunotherapy in mutant P301L mice: antibody affinity versus specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Mechanisms of protein seeding in neurodegenerative diseases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Lost in transgenesis: a user's guide for genetically manipulating the mouse in cardiac research

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Physiochemical and biochemical factors influencing the pharmacokinetics of antibody therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Cognitive and sensorimotor tasks for assessing functional impairments in mouse models of Alzheimer's disease and related disorders

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Mechanistic Studies of Antibody-Mediated Clearance of Tau Aggregates Using an ex vivo Brain Slice Model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Combined actions of Na/K-ATPase, NCX1 and glutamate dependent NMDA receptors in ischemic rat brain penumbra

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Characterization of a novel SOD-1(G93A) transgenic mouse line with very decelerated disease development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Pathogenic missense MAPT mutations differentially modulate tau aggregation propensity at nucleation and extension steps

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Nucleation-dependent tau filament formation: the importance of dimerization and an estimation of elementary rate constants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5006503

21 June 2018

Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements.

1 reference

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1 reference

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1 reference

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21 June 2018

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

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21 June 2018

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1186%2FS13024-016-0126-Z

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Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

1 reference

https://api.crossref.org/works/10.1186%2FS13024-016-0126-Z

21 January 2018

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

1 reference

https://api.crossref.org/works/10.1186%2FS13024-016-0126-Z

21 January 2018

Reduced elimination of IgG antibodies by engineering the variable region.

1 reference

https://api.crossref.org/works/10.1186%2FS13024-016-0126-Z

21 January 2018

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms.

1 reference

https://api.crossref.org/works/10.1186%2FS13024-016-0126-Z

21 January 2018

Purification of paired helical filament tau and normal tau from human brain tissue

1 reference

https://api.crossref.org/works/10.1186%2FS13024-016-0126-Z

21 January 2018

Histological staining of amyloid and pre-amyloid peptides and proteins in mouse tissue

1 reference

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21 January 2018

Long-term culture of mouse cortical neurons as a model for neuronal development, aging, and death

1 reference

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21 January 2018

Infectivity of amyloid diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/27578006

12 December 2020

based on heuristic

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10.1186/S13024-016-0126-Z

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Europe PubMed Central

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22 March 2020

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22 March 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27578006%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

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