(Q48624391)

13 February 2018

title

Neuronal uptake of tau/pS422 antibody and reduced progression of tau pathology in a mouse model of Alzheimer's disease. (English)

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13 February 2018

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Ludovic Collin

1

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13 February 2018

Bernd Bohrmann

2

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13 February 2018

Ulrich Göpfert

3

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13 February 2018

Krisztina Oroszlan-Szovik

4

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13 February 2018

Laurence Ozmen

5

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13 February 2018

Fiona Grüninger

6

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13 February 2018

language of work or name

English

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publication date

31 July 2014

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13 February 2018

published in

Brain

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13 February 2018

volume

137

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13 February 2018

issue

Pt 10

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13 February 2018

page(s)

2834-2846

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13 February 2018

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

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Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain

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Phosphorylated serine422 on tau proteins is a pathological epitope found in several diseases with neurofibrillary degeneration.

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Passive immunization with Tau oligomer monoclonal antibody reverses tauopathy phenotypes without affecting hyperphosphorylated neurofibrillary tangles.

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Motor training compensates for cerebellar dysfunctions caused by oligodendrocyte ablation

21 January 2018

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Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.

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21 January 2018

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Alpha-synuclein induces lysosomal rupture and cathepsin dependent reactive oxygen species following endocytosis

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Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.

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Interaction of tau protein with model lipid membranes induces tau structural compaction and membrane disruption

21 January 2018

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Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy

21 January 2018

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Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease.

21 January 2018

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Activation of the ERK and JNK signaling pathways caused by neuron-specific inhibition of PP2A in transgenic mice

21 January 2018

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21 January 2018

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Early accumulation of p62 in neurofibrillary tangles in Alzheimer's disease: possible role in tangle formation.

21 January 2018

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21 January 2018

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21 January 2018

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Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments

21 January 2018

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Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature

21 January 2018

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Expression of transgenic APP mRNA is the key determinant for beta-amyloid deposition in PS2APP transgenic mice.

21 January 2018

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Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease.

21 January 2018

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Different tau epitopes define Abeta42-mediated tau insolubility

21 January 2018

1 reference

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Functional implications of the association of tau with the plasma membrane.

21 January 2018

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Physiological release of endogenous tau is stimulated by neuronal activity.

21 January 2018

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21 January 2018

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Lipid rafts: signaling and sorting platforms of cells and their roles in cancer

21 January 2018

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Targeting phospho-Ser422 by active Tau Immunotherapy in the THYTau22 mouse model: a suitable therapeutic approach

21 January 2018

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Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer's disease

21 January 2018

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Membrane rafts in Alzheimer's disease beta-amyloid production

21 January 2018

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Hsp70 alters tau function and aggregation in an isoform specific manner

21 January 2018

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The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU213

Anti-tau antibodies that block tau aggregate seeding in vitro markedly decrease pathology and improve cognition in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU213

Monitoring autophagy in Alzheimer's disease and related neurodegenerative diseases.

21 January 2018

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https://api.crossref.org/works/10.1093%2FBRAIN%2FAWU213

21 January 2018

Identifiers

DOI

10.1093/BRAIN/AWU213

1 reference

13 February 2018

PubMed ID

25085375

1 reference

13 February 2018