(Q30981900)

28 June 2017

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title

Data integration: challenges for drug discovery (English)

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28 June 2017

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David B Searls

1

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publication date

1 January 2005

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Nature Reviews Drug Discovery

28 June 2017

published in

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28 June 2017

volume

4

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28 June 2017

issue

1

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28 June 2017

page(s)

45-58

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Reconstructing pharmaceutical instinct

28 June 2017

cites work

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Integrating biological databases

21 January 2018

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Informatics and hypothesis-driven research

21 January 2018

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Integrating 'omic' information: a bridge between genomics and systems biology

21 January 2018

1 reference

Biomedical informatics for proteomics

21 January 2018

1 reference

DNA microarrays: vital statistics.

21 January 2018

1 reference

Identifying differentially expressed genes using false discovery rate controlling procedures

21 January 2018

1 reference

Methods for assessing reproducibility of clustering patterns observed in analyses of microarray data

21 January 2018

1 reference

Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification

21 January 2018

1 reference

At the interfaces of epidemiology, genetics and genomics

21 January 2018

1 reference

Microarray data normalization and transformation

21 January 2018

1 reference

A comparison of statistical methods for analysis of high density oligonucleotide array data

21 January 2018

1 reference

Analysis of matched mRNA measurements from two different microarray technologies

21 January 2018

1 reference

Fundamentals of experimental design for cDNA microarrays

21 January 2018

1 reference

Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation

21 January 2018

1 reference

Testing for differentially-expressed genes by maximum-likelihood analysis of microarray data

21 January 2018

1 reference

A comparative review of statistical methods for discovering differentially expressed genes in replicated microarray experiments

21 January 2018

1 reference

Assessing gene significance from cDNA microarray expression data via mixed models

21 January 2018

1 reference

Meta-analysis: principles and procedures

21 January 2018

1 reference

What's wrong with Bonferroni adjustments

21 January 2018

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Multiple test procedures other than Bonferroni's deserve wider use.

21 January 2018

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Meta-analysis of gene expression in mouse preimplantation embryo development

21 January 2018

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Microarray expression profiling identifies genes with altered expression in HDL-deficient mice

21 January 2018

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Significance analysis of microarrays applied to the ionizing radiation response

21 January 2018

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21 January 2018

Inventories to insights

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Joint analysis of two microarray gene-expression data sets to select lung adenocarcinoma marker genes

21 January 2018

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Independent component analysis of microarray data in the study of endometrial cancer.

21 January 2018

1 reference

A map of the interactome network of the metazoan C. elegans

21 January 2018

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Data integration--connecting the dots

21 January 2018

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Pharmacophylogenomics: genes, evolution and drug targets

21 January 2018

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Chemogenomics: an emerging strategy for rapid target and drug discovery

21 January 2018

1 reference

Pegasys: software for executing and integrating analyses of biological sequences

21 January 2018

1 reference

Congruence of tissue expression profiles from Gene Expression Atlas, SAGEmap and TissueInfo databases

21 January 2018

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Analyzing yeast protein-protein interaction data obtained from different sources

21 January 2018

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Cluster analysis and display of genome-wide expression patterns

21 January 2018

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Pharmacogenomic analysis: correlating molecular substructure classes with microarray gene expression data

21 January 2018

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Detection of regulatory circuits by integrating the cellular networks of protein-protein interactions and transcription regulation

21 January 2018

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A graph-theoretic modeling on GO space for biological interpretation of gene clusters

21 January 2018

1 reference

A Bayesian Networks Approach for Predicting Protein-Protein Interactions from Genomic Data

21 January 2018

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A Bayesian framework for combining heterogeneous data sources for gene function prediction (in Saccharomyces cerevisiae).

21 January 2018

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Use of gene networks for identifying and validating drug targets

21 January 2018

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21 January 2018

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Network biology: understanding the cell's functional organization

21 January 2018

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Metabolic network structure determines key aspects of functionality and regulation

21 January 2018

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Interplay of transcriptomics and proteomics

21 January 2018

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Design and implementation of microarray gene expression markup language (MAGE-ML)

21 January 2018

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Minimum information about a microarray experiment (MIAME)-toward standards for microarray data

21 January 2018

1 reference

The HUPO PSI's molecular interaction format--a community standard for the representation of protein interaction data

21 January 2018

1 reference

Genew: the human gene nomenclature database

21 January 2018

1 reference

RefSeq and LocusLink: NCBI gene-centered resources

21 January 2018

1 reference

Ontologies in biology: design, applications and future challenges

21 January 2018

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An ontology for collaborative construction and analysis of cellular pathways.

21 January 2018

1 reference

Bio-ontologies-fast and furious

21 January 2018

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Issues in the design of medical ontologies used for knowledge sharing

21 January 2018

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TAMBIS: transparent access to multiple bioinformatics information sources

21 January 2018

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SEMEDA: ontology based semantic integration of biological databases

21 January 2018

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Bioinformatics and clinical informatics: the imperative to collaborate

21 January 2018

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Quantitative real-time reverse transcription polymerase chain reaction: normalization to rRNA or single housekeeping genes is inappropriate for human tissue biopsies.

21 January 2018

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PowerPoint: shot with its own bullets

21 January 2018

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Tagging gene and protein names in biomedical text

21 January 2018

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21 January 2018

Molecular epidemiology

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Temporal logics and real time expert systems

21 January 2018

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QAV: querying entity-attribute-value metadata in a biomedical database

21 January 2018

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Organization of heterogeneous scientific data using the EAV/CR representation

21 January 2018

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Systematic determination of genetic network architecture

21 January 2018

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2HAPI: a microarray data analysis system.

21 January 2018

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REDUCE: An online tool for inferring cis-regulatory elements and transcriptional module activities from microarray data

21 January 2018

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INCLUSive: A web portal and service registry for microarray and regulatory sequence analysis

21 January 2018

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A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules

21 January 2018

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Discovering novel cis-regulatory motifs using functional networks

21 January 2018

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Predicting protein-peptide interactions via a network-based motif sampler

21 January 2018

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Automated modelling of signal transduction networks

21 January 2018

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Integration of genomic datasets to predict protein complexes in yeast

21 January 2018

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Predicting co-complexed protein pairs using genomic and proteomic data integration

21 January 2018

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Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.

21 January 2018

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High-throughput protein analysis integrating bioinformatics and experimental assays.

21 January 2018

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Genetic analysis of genome-wide variation in human gene expression

21 January 2018

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WebQTL: web-based complex trait analysis

21 January 2018

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21 January 2018

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Large-scale co-evolution analysis of protein structural interlogues using the global protein structural interactome map (PSIMAP).

21 January 2018

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Kinomics-structural biology and chemogenomics of kinase inhibitors and targets

21 January 2018

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Prediction of clinical drug efficacy by classification of drug-induced genomic expression profiles in vitro

21 January 2018

1 reference

Gene expression analysis for high throughput screening applications.

21 January 2018

1 reference

Protein-protein interactions: mechanisms and modification by drugs

21 January 2018

1 reference

Mini-review: computational structure-based design of inhibitors that target protein surfaces

21 January 2018

1 reference

EnsMart: a generic system for fast and flexible access to biological data

21 January 2018

1 reference

GeneLynx: a gene-centric portal to the human genome

21 January 2018

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GeneCards 2002: towards a complete, object-oriented, human gene compendium

21 January 2018

1 reference

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

21 January 2018

1 reference

FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes

21 January 2018

1 reference

GoMiner: a resource for biological interpretation of genomic and proteomic data

21 January 2018

1 reference

Characterizing gene sets with FuncAssociate

21 January 2018

1 reference

New strategy for the representation and the integration of biomolecular knowledge at a cellular scale

21 January 2018

1 reference

PubMatrix: a tool for multiplex literature mining

21 January 2018

1 reference

Advances in high content screening for drug discovery

21 January 2018

1 reference

A literature network of human genes for high-throughput analysis of gene expression

21 January 2018

1 reference

Text Influenced Molecular Indexing (TIMI): a literature database mining approach that handles text and chemistry

21 January 2018

1 reference

DAVID: Database for Annotation, Visualization, and Integrated Discovery

21 January 2018

1 reference

GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways

21 January 2018

1 reference

Early prediction of drug metabolism and toxicity: systems biology approach and modeling

21 January 2018

1 reference

The COG database: an updated version includes eukaryotes

21 January 2018

1 reference

OrthoMCL: Identification of Ortholog Groups for Eukaryotic Genomes

21 January 2018

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Cross-referencing eukaryotic genomes: TIGR Orthologous Gene Alignments (TOGA)

21 January 2018

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21 January 2018

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Absence of transitive and systemic pathways allows cell-specific and isoform-specific RNAi in Drosophila

21 January 2018

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Data diving with cross-validation: an investigation of broad-scale gradients in Swedish weed communities

21 January 2018

1 reference

It's sink or swim as a tidal wave of data approaches

21 January 2018

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Integromics: challenges in data integration

21 January 2018

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NASA reworks its sums after Mars fiasco

31 March 2020

1 reference

Lessons in molecular gymnastics

31 March 2020

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Technologies for integrating biological data

31 March 2020

1 reference

Computational knowledge integration in biopharmaceutical research

31 March 2020

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Integrative analysis of multiple gene expression profiles applied to liver cancer study

31 March 2020

1 reference

'Omic' and hypothesis-driven research in the molecular pharmacology of cancer

31 March 2020

1 reference

Data dredging, bias, or confounding

31 March 2020

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The problem of multiple inference in studies designed to generate hypotheses

31 March 2020

1 reference

Independent component analysis: an introduction

31 March 2020

1 reference

GSCope: a clipped fisheye viewer effective for highly complicated biomolecular network graphs

31 March 2020

1 reference

Trends in computational biology: a summary based on a RECOMB plenary lecture, 1999.

31 March 2020

1 reference

Dyslexia: the possible benefit of multimodal integration of fMRI- and EEG-data

31 March 2020

1 reference

Globally distributed object identification for biological knowledgebases

31 March 2020

1 reference

Ontology-based knowledge representation for bioinformatics

31 March 2020

1 reference

Using the Unified Modelling Language (UML) to guide the systemic description of biological processes and systems

31 March 2020

1 reference

Important issues in knowledge representation

31 March 2020

1 reference

Causation in epidemiology

31 March 2020

1 reference

Environmental epidemiology: basics and proof of cause-effect

31 March 2020

1 reference

On indefinite databases and the closed world assumption

31 March 2020

1 reference

31 March 2020

1 reference

Metadata-driven creation of data marts from an EAV-modeled clinical research database

31 March 2020

1 reference

CRASP: a program for analysis of coordinated substitutions in multiple alignments of protein sequences.

31 March 2020

1 reference

ADVICE: Automated Detection and Validation of Interaction by Co-Evolution.

31 March 2020

1 reference

InterWeaver: interaction reports for discovering potential protein interaction partners with online evidence

31 March 2020

1 reference

Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

31 March 2020

1 reference

RESOURCERER: a database for annotating and linking microarray resources within and across species

31 March 2020

1 reference

Automatically identifying gene/protein terms in MEDLINE abstracts.

31 March 2020

1 reference

The human genome browser at UCSC

31 March 2020

1 reference

Interaction and domain networks of yeast

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRD1608

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release_nljkd23lrfhh5ajfvykl3j5oti

28 June 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/nljkd23lrfhh5ajfvykl3j5oti

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference