(Q31072774)

28 June 2017

The effects of reactive site location on the inhibitory properties of the serpin alpha(1)-antichymotrypsin (English)

1 reference

28 June 2017

Michael I Plotnick

1

1 reference

28 June 2017

Harvey Rubin

series ordinal

2

1 reference

28 June 2017

Norman M Schechter

series ordinal

3

1 reference

28 June 2017

language of work or name

English

0 references

publication date

7 June 2002

1 reference

Journal of Biological Chemistry

28 June 2017

1 reference

28 June 2017

277

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28 June 2017

33

1 reference

28 June 2017

29927-29935

1 reference

Human plasma proteinase inhibitors

28 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Natural protein proteinase inhibitors and their interaction with proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

On the size of the active site in proteases. I. Papain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Structure of a serpin-protease complex shows inhibition by deformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Formation of the covalent serpin-proteinase complex involves translocation of the proteinase by more than 70 A and full insertion of the reactive center loop into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Formation of the covalent chymotrypsin.antichymotrypsin complex involves no large-scale movement of the enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

The structural basis for neutrophil inactivation of C1 inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Heparin binding site, conformational change, and activation of antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

The serpin inhibitory mechanism is critically dependent on the length of the reactive center loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Purification and identification of two serine class proteinases from dog mast biochemically and immunologically similar to human proteinases tryptase and chymase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Site-directed mutagenesis by overlap extension using the polymerase chain reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Recombinant expression of human mast cell proteases chymase and tryptase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

The 2.2 A crystal structure of human chymase in complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone: structural explanation for its dipeptidyl carboxypeptidase specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Structural change in alpha-chymotrypsin induced by complexation with alpha 1-antichymotrypsin as seen by enhanced sensitivity to proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

The pH dependence of serpin-proteinase complex dissociation reveals a mechanism of complex stabilization involving inactive and active conformational states of the proteinase which are perturbable by calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Heterogeneity in serpin-protease complexes as demonstrated by differences in the mechanism of complex breakdown

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

The structure of rat mast cell protease II at 1.9-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Alpha 1-proteinase inhibitor variant T345R. Influence of P14 residue on substrate and inhibitory pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Partitioning of serpin-proteinase reactions between stable inhibition and substrate cleavage is regulated by the rate of serpin reactive center loop insertion into beta-sheet A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

The serpin MNEI inhibits elastase-like and chymotrypsin-like serine proteases through efficient reactions at two active sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Human cytoplasmic antiproteinase neutralizes rapidly and efficiently chymotrypsin and trypsin-like proteases utilizing distinct reactive site residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Kinetics of interaction of C1 inhibitor with complement C1s.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Structure of alpha-chymotrypsin refined at 1.68 A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Mobile reactive centre of serpins and the control of thrombosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

The structure of a serpin-protease complex revealed by intramolecular distance measurements using donor-donor energy migration and mapping of interaction sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Topology of the stable serpin-protease complexes revealed by an autoantibody that fails to react with the monomeric conformers of antithrombin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Importance of the hinge region between alpha-helix F and the main part of serpins, based upon identification of the epitope of plasminogen activator inhibitor type 1 neutralizing antibodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Evidence for the extent of insertion of the active site loop of intact alpha 1 proteinase inhibitor in beta-sheet A

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Alpha-2-antiplasmin: a serpin with two separate but overlapping reactive sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Conversion of alpha 1-antichymotrypsin into a human neutrophil elastase inhibitor: demonstration of variants with different association rate constants, stoichiometries of inhibition, and complex stabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Trypsin complexed with alpha 1-proteinase inhibitor has an increased structural flexibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Role of the P6-P3' region of the serpin reactive loop in the formation and breakdown of the inhibitory complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Diverse effects of pH on the inhibition of human chymase by serpins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Distortion of the active site of chymotrypsin complexed with a serpin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Mechanism of serpin action: evidence that C1 inhibitor functions as a suicide substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

Inhibitory mechanism of serpins: loop insertion forces acylation of plasminogen activator by plasminogen activator inhibitor-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M202374200

21 January 2018

Identifiers

DOI

10.1074/JBC.M202374200

1 reference

28 June 2017

1 reference