(Q31125501)

29 June 2017

Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells (English)

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29 June 2017

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7

Eva-Maria Mandelkow

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Zuzana Gazova

object named as

Zuzana Gazova

2

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Eckhard Mandelkow

9

object named as

Eckhard Mandelkow

1 reference

29 June 2017

3

Martin von Bergen

1 reference

29 June 2017

Marcus Pickhardt

1

1 reference

29 June 2017

Inna Khlistunova

4

1 reference

29 June 2017

Yipeng Wang

5

1 reference

29 June 2017

Antje Hascher

6

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29 June 2017

Jacek Biernat

8

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29 June 2017

language of work or name

English

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publication date

2 November 2004

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Journal of Biological Chemistry

29 June 2017

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29 June 2017

280

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29 June 2017

3628-3635

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29 June 2017

5

1 reference

Folding proteins in fatal ways

29 June 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Neuropathological stageing of Alzheimer-related changes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Neurodegenerative tauopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Analysis of tauopathies with transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Huntington's disease: the mystery unfolds?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Protofibrils, pores, fibrils, and neurodegeneration: separating the responsible protein aggregates from the innocent bystanders

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Inhibition of huntingtin fibrillogenesis by specific antibodies and small molecules: implications for Huntington's disease therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

A nucleated assembly mechanism of Alzheimer paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Studying gene function in eukaryotes by conditional gene inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Phenotypic variation in hereditary frontotemporal dementia with tau mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Structure, stability, and aggregation of paired helical filaments from tau protein and FTDP-17 mutants probed by tryptophan scanning mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Oligomerization of endogenous and synthetic amyloid beta-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Toward a unified scheme for the aggregation of tau into Alzheimer paired helical filaments

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Prevention of transthyretin amyloid disease by changing protein misfolding energetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Structural analysis of Alzheimer's beta(1-40) amyloid: protofilament assembly of tubular fibrils.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Exploring amyloid formation by a de novo design

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Designing conditions for in vitro formation of amyloid protofilaments and fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Structure and texture of fibrous crystals formed by Alzheimer's abeta(11-25) peptide fragment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

A possible role for pi-stacking in the self-assembly of amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

De novo designed peptide-based amyloid fibrils

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

The relation of the properties of Congo red-stained amyloid fibrils to the -conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

X-ray diffraction from intraneuronal paired helical filaments and extraneuronal amyloid fibers in Alzheimer disease indicates cross-beta conformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Differential regulation of microtubule dynamics by three- and four-repeat tau: implications for the onset of neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Ligand-dependent inhibition and reversal of tau filament formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Common structural features determine the effectiveness of carvedilol, daunomycin and rolitetracycline as inhibitors of Alzheimer beta-amyloid fibril formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

4 ′‐iodo‐4′‐Deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Discovery of compounds that will prevent tau pathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

GSK3 inhibitors: development and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Alzheimer Neurofibrillary Degeneration: Therapeutic Targets and High-Throughput Assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Tau assembly in inducible transfectants expressing wild-type or FTDP-17 tau.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

beta-Amyloid induces paired helical filament-like tau filaments in tissue culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M410984200

21 January 2018

Identifiers

DOI

10.1074/JBC.M410984200

1 reference

29 June 2017

1 reference