(Q31814859)

30 September 2017

Beyond CDR-grafting: Structure-guided humanization of framework and CDR regions of an anti-myostatin antibody (English)

1 reference

identical protein binding

30 September 2017

1 reference

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

James R Apgar

1

1 reference

30 September 2017

Michelle Mader

2

1 reference

30 September 2017

Rita Agostinelli

3

1 reference

30 September 2017

Susan Benard

4

1 reference

30 September 2017

Peter Bialek

5

1 reference

30 September 2017

Mark Johnson

6

1 reference

30 September 2017

Yijie Gao

7

1 reference

30 September 2017

Mark Krebs

8

1 reference

30 September 2017

Jane Owens

9

1 reference

30 September 2017

Kevin Parris

10

1 reference

30 September 2017

Michael St Andre

11

1 reference

30 September 2017

Kris Svenson

12

1 reference

30 September 2017

Carl Morris

13

1 reference

30 September 2017

Lioudmila Tchistiakova

14

1 reference

30 September 2017

13 September 2016

1 reference

30 September 2017

Monoclonal Antibodies

1 reference

30 September 2017

8

1 reference

30 September 2017

7

1 reference

30 September 2017

1302-1318

1 reference

Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies

30 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

AB-Bind: Antibody binding mutational database for computational affinity predictions.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

A Web Resource for Standardized Benchmark Datasets, Metrics, and Rosetta Protocols for Macromolecular Modeling and Design

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Antibody humanization by structure-based computational protein design.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

The therapeutic monoclonal antibody market

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

In silico selection of therapeutic antibodies for development: viscosity, clearance, and chemical stability

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

T-cell dependent immunogenicity of protein therapeutics: Preclinical assessment and mitigation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Monoclonal antibody humanness score and its applications

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Humanization of antibodies using heavy chain complementarity-determining region 3 grafting coupled with in vitro somatic hypermutation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Frontier of therapeutic antibody discovery: The challenges and how to face them

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Myostatin as a therapeutic target in Amyotrophic lateral sclerosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Specificity and Structure of a High Affinity Activin Receptor-like Kinase 1 (ALK1) Signaling Complex

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Computational prediction of protein hot spot residues

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Structure of Myostatin·Follistatin-like 3

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Immunogenicity of protein therapeutics: The key causes, consequences and challenges

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

The immunogenicity of humanized and fully human antibodies: residual immunogenicity resides in the CDR regions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Characterization of the ligand binding functionality of the extracellular domain of activin receptor type IIb.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Features and development of Coot

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Predictive tools for stabilization of therapeutic proteins.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

The structure of myostatin:follistatin 288: insights into receptor utilization and heparin binding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

BMP-7 as antagonist of organ fibrosis

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Bone morphogenetic protein (BMP) and activin type II receptors balance BMP9 signals mediated by activin receptor-like kinase-1 in human pulmonary artery endothelial cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Reducing risk, improving outcomes: bioengineering less immunogenic protein therapeutics

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Crystal structure analysis reveals a spring-loaded latch as molecular mechanism for GDF-5-type I receptor specificity

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Stabilization and humanization of a single-chain Fv antibody fragment specific for human lymphocyte antigen CD19 by designed point mutations and CDR-grafting onto a human framework

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Fully human antibodies from transgenic mouse and phage display platforms

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Myostatin as a therapeutic target for musculoskeletal disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

A phase I/IItrial of MYO-029 in adult subjects with muscular dystrophy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Role of transforming growth factor-beta superfamily signaling pathways in human disease

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

BMP-3 and BMP-6 structures illuminate the nature of binding specificity with receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

A silent H-bond can be mutationally activated for high-affinity interaction of BMP-2 and activin type IIB receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Fully human therapeutic monoclonal antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Crystal structure of BMP-9 and functional interactions with pro-region and receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

SDR grafting--a new approach to antibody humanization

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Immunogenicity of engineered antibodies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

A flexible activin explains the membrane-dependent cooperative assembly of TGF-beta family receptors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicity.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Myostatin mutation associated with gross muscle hypertrophy in a child

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Biophysical properties of human antibody variable domains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

A simple physical model for binding energy hot spots in protein-protein complexes

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Gene expression in sexually dimorphic muscles in sheep

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Improving the efficacy of antibody-based cancer therapies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Implementation of molecular replacement in AMoRe

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

GDF-8 propeptide binds to GDF-8 and antagonizes biological activity by inhibiting GDF-8 receptor binding

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Analysis of a data set of paired uncomplexed protein structures: new metrics for side-chain flexibility and model evaluation.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Structural correlates of an anticarcinoma antibody: identification of specificity-determining residues (SDRs) and development of a minimally immunogenic antibody variant by retention of SDRs only

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Phase I evaluation of humanized OKT3: toxicity and immunomodulatory effects of hOKT3gamma4.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Double muscling in cattle due to mutations in the myostatin gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Mutations in myostatin (GDF8) in double-muscled Belgian Blue and Piedmontese cattle

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Anatomy of the antibody molecule

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Domain association in immunoglobulin molecules. The packing of variable domains

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Contractile properties of skeletal muscles from young, adult and aged mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Reshaping human antibodies for therapy

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

A humanized antibody that binds to the interleukin 2 receptor

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Use of human germline genes in a CDR homology-based approach to antibody humanization.

21 June 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

An engineered human antibody fab fragment specific for Pseudomonas aeruginosa PcrV antigen has potent antibacterial activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

A molecular immunology approach to antibody humanization and functional optimization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

The influence of the framework core residues on the biophysical properties of immunoglobulin heavy chain variable domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

Analysis of myostatin gene structure, expression and function in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

Gross muscle hypertrophy in whippet dogs is caused by a mutation in the myostatin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

Clinical validation of the "in silico" prediction of immunogenicity of a human recombinant therapeutic protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

Analyzing the "degree of humanness" of antibody sequences.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

Therapeutic Antibody Engineering To Improve Viscosity and Phase Separation Guided by Crystal Structure

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

Computational alanine scanning of protein-protein interfaces

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Expression of chimeric genes in the early region of SV40

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5058614

Stability scale and atomic solvation parameters extracted from 1023 mutation experiments

31 October 2018

1 reference

https://api.crossref.org/works/10.1080%2F19420862.2016.1215786

"Superhumanized" antibodies: reduction of immunogenic potential by complementarity-determining region grafting with human germline sequences: application to an anti-CD28

21 January 2018

1 reference

12 December 2020

Comprehensive pharmacokinetics of a humanized antibody and analysis of residual anti-idiotypic responses

1 reference

12 December 2020

Serological analysis of human anti-human antibody responses in colon cancer patients treated with repeated doses of humanized monoclonal antibody A33

1 reference

12 December 2020

Improving biosensor analysis

1 reference

12 December 2020

Myostatin inhibition slows muscle atrophy in rodent models of amyotrophic lateral sclerosis

1 reference

12 December 2020

The anti-idiotypic response by cynomolgus monkeys to humanized anti-Tac is primarily directed to complementarity-determining regions H1, H2, and L3

1 reference

12 December 2020

Antibody framework residues affecting the conformation of the hypervariable loops

1 reference

12 December 2020

10.1080/19420862.2016.1215786

Identifiers

DOI

1 reference

30 September 2017

1 reference

30 September 2017

PubMed publication ID

27625211

1 reference