(Q33301976)

25 July 2017

1 reference

title

Identifying small molecule inhibitors of eukaryotic translation initiation (English)

1 reference

25 July 2017

Regina Cencic

1

1 reference

25 July 2017

Francis Robert

series ordinal

2

1 reference

25 July 2017

Jerry Pelletier

series ordinal

3

1 reference

25 July 2017

language of work or name

English

0 references

publication date

1 January 2007

1 reference

25 July 2017

Methods in Enzymology

1 reference

25 July 2017

431

1 reference

25 July 2017

269-302

1 reference

Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole

25 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Clotrimazole inhibits cell proliferation in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Modulation of protein-protein interactions with small organic molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Biochemical characterisation of cap-poly(A) synergy in rabbit reticulocyte lysates: the eIF4G-PABP interaction increases the functional affinity of eIF4E for the capped mRNA 5'-end

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Homogenous time resolved fluorescence assay to identify modulators of cap-dependent translation initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Dissecting the ribosomal inhibition mechanisms of edeine and pactamycin: the universally conserved residues G693 and C795 regulate P-site RNA binding

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

A noncommercial dual luciferase enzyme assay system for reporter gene analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

High-level synthesis in Escherichia coli of functional cap-binding eukaryotic initiation factor eIF-4E and affinity purification using a simplified cap-analog resin

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Current development of mTOR inhibitors as anticancer agents

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

4E binding proteins inhibit the translation factor eIF4E without folded structure

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

The interaction of eIF4E with 4E-BP1 is an induced fit to a completely disordered protein

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Regulation of translation initiation by FRAP/mTOR

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

A novel functional human eukaryotic translation initiation factor 4G

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Ribosome loading onto the mRNA cap is driven by conformational coupling between eIF4G and eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Perk is essential for translational regulation and cell survival during the unfolded protein response

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

The Cap-binding protein eIF4E promotes folding of a functional domain of yeast translation initiation factor eIF4G1.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: role of La autoantigen in XIAP translation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Translational control in stress and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Factorless ribosome assembly on the internal ribosome entry site of cricket paralysis virus

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

The molecular mechanics of eukaryotic translation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Mechanism of ribosome recruitment by hepatitis C IRES RNA

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

A microtiter plate assay for assessing the interaction of eukaryotic initiation factor eIF4E with eIF4G and eIF4E binding protein-1

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Characterization of the two eIF4A-binding sites on human eIF4G-1

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Prospective study of eukaryotic initiation factor 4E protein elevation and breast cancer outcome

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Overexpression of eukaryotic initiation factor 4E (eIF4E) in breast carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Translation initiation factor 4E blocks endoplasmic reticulum-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Translation factor eIF4E rescues cells from Myc-dependent apoptosis by inhibiting cytochrome c release.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Antimicrobial drug discovery through bacteriophage genomics.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Inhibitory properties of nucleic acid-binding ligands on protein synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Inhibitors of protein synthesis identified by a high throughput multiplexed translation screen

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Influence of correct secondary and tertiary RNA folding on the binding of cellular factors to the HCV IRES

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Translation elongation after assembly of ribosomes on the Cricket paralysis virus internal ribosomal entry site without initiation factors or initiator tRNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Molecular mechanisms of translation initiation in eukaryotes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Position of the CrPV IRES on the 40S subunit and factor dependence of IRES/80S ribosome assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Functional dissection of eukaryotic initiation factor 4F: the 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Translation initiation by factor-independent binding of eukaryotic ribosomes to internal ribosomal entry sites

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Introduction LANCEtrade mark vs. HTRF(R) Technologies (or Vice Versa)

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Cooperative modulation by eIF4G of eIF4E-binding to the mRNA 5' cap in yeast involves a site partially shared by p20.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Chlorolissoclimides: new inhibitors of eukaryotic protein synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Initiation of Protein Synthesis by Hepatitis C Virus Is Refractory to Reduced eIF2 · GTP · Met-tRNAiMet Ternary Complex Availability

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

eIF4A: the godfather of the DEAD box helicases

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

The role of translation in neoplastic transformation from a pathologist's point of view

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Identification of nuclear cap specific proteins in HeLa cells

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Structure of the ribosome-bound cricket paralysis virus IRES RNA.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Structural and thermodynamic behavior of eukaryotic initiation factor 4E in supramolecular formation with 4E-binding protein 1 and mRNA cap analogue, studied by spectroscopic methods

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

ATP/Mg++-dependent cross-linking of cap binding proteins to the 5′ end of eukaryotic mRNA

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Reovirus mRNA can be covalently crosslinked via the 5' cap to proteins in initiation complexes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Actions of aurintricarboxylate, kasugamycin, and pactamycin on Escherichia coli polysomes

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Association of the yeast poly(A) tail binding protein with translation initiation factor eIF-4G

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Structural basis for mRNA Cap-Binding regulation of eukaryotic initiation factor 4E by 4E-binding protein, studied by spectroscopic, X-ray crystal structural, and molecular dynamics simulation methods

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Folding transitions during assembly of the eukaryotic mRNA cap-binding complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

New technologies for chemical genetics

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

PTC124 targets genetic disorders caused by nonsense mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Initiation of protein synthesis from the A site of the ribosome

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Automatic recording of viscosity changes with the Ostwald capillary viscometer

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Specific interaction of eukaryotic translation initiation factor 3 with the 5' nontranslated regions of hepatitis C virus and classical swine fever virus RNAs

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

Importance of ribosomal frameshifting for human immunodeficiency virus type 1 particle assembly and replication

1 reference

https://api.crossref.org/works/10.1016%2FS0076-6879%2807%2931013-6

7 January 2021

10.1016/S0076-6879(07)31013-6

Identifiers

DOI

1 reference

25 July 2017

1 reference