(Q33371239)

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Modulation of TNFalpha, a determinant of acute toxicity associated with systemic delivery of first-generation and helper-dependent adenoviral vectors

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scholarly article

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Europe PubMed Central

PubMed publication ID

26 July 2017

Modulation of TNFalpha, a determinant of acute toxicity associated with systemic delivery of first-generation and helper-dependent adenoviral vectors (English)

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

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L Pastore

8

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Gabriele Toietta

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G Toietta

2

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author name string

V P Mane

1

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

W M McCormack

3

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Europe PubMed Central

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26 July 2017

I Conde

4

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

C Clarke

5

1 reference

Europe PubMed Central

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26 July 2017

D Palmer

6

1 reference

Europe PubMed Central

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26 July 2017

M J Finegold

7

1 reference

Europe PubMed Central

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26 July 2017

P Ng

9

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

J Lopez

10

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Europe PubMed Central

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26 July 2017

B Lee

11

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Europe PubMed Central

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26 July 2017

publication date

18 May 2006

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Europe PubMed Central

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26 July 2017

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Europe PubMed Central

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26 July 2017

13

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26 July 2017

17

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Europe PubMed Central

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26 July 2017

1272-1280

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

The innate immune response to adenovirus vectors

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The pathophysiology and treatment of sepsis

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Lethal toxicity, severe endothelial injury, and a threshold effect with high doses of an adenoviral vector in baboons

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Tumour necrosis factor blocking agents: a new therapeutic modality for inflammatory disorders

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The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations

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Increased hepatic transduction with reduced systemic dissemination and proinflammatory cytokines following hydrodynamic injection of helper-dependent adenoviral vectors.

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Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages

1 reference

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Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors.

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Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer

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The role of capsid-endothelial interactions in the innate immune response to adenovirus vectors

1 reference

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High doses of a helper-dependent adenoviral vector yield supraphysiological levels of alpha1-antitrypsin with negligible toxicity

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Sustained human factor VIII expression in hemophilia A mice following systemic delivery of a gutless adenoviral vector

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Helper-dependent adenovirus vectors elicit intact innate but attenuated adaptive host immune responses in vivo

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Toxicological comparison of E2a-deleted and first-generation adenoviral vectors expressing alpha1-antitrypsin after systemic delivery

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Intravenous administration of recombinant adenoviruses causes thrombocytopenia, anemia and erythroblastosis in rabbits

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A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency

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Multiple cases of life-threatening adenovirus pneumonia in a mental health care center

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Adenoviral vectors do not induce, inhibit, or potentiate human platelet aggregation

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Acute toxicity after high-dose systemic injection of helper-dependent adenoviral vectors into nonhuman primates.

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Interferons: cell signalling, immune modulation, antiviral response and virus countermeasures

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Tumor necrosis factor alpha plays a central role in immune-mediated clearance of adenoviral vectors

1 reference

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TNF-alpha -dependent maturation of local dendritic cells is critical for activating the adaptive immune response to virus infection

1 reference

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Activation of platelet caspases by TNF and its consequences for kinetics

1 reference

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Role of mast cells and monoamines in the thrombocytopaenia and mortality elicited by tumour necrosis factor in mice

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Role of cytokines in rheumatoid arthritis

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Etanercept (Enbrel): update on therapeutic use

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Sustained phenotypic correction of canine hemophilia B after systemic administration of helper-dependent adenoviral vector

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Evaluation of toxicity from high-dose systemic administration of recombinant adenovirus vector in vector-naive and pre-immunized mice.

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The role of IL-6 in the inflammatory and humoral response to adenoviral vectors

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Toxicity of a first-generation adenoviral vector in rhesus macaques

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Recombinant human tumor necrosis factor receptor (p75) Fc fusion protein (TNFR:Fc) in rheumatoid arthritis

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The release of inflammatory cytokines from human peripheral blood mononuclear cells in vitro following exposure to adenovirus variants and capsid

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Adenovirus vectors for gene delivery

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Bilamellar cationic liposomes protect adenovectors from preexisting humoral immune responses

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PEGylation of E1-deleted adenovirus vectors allows significant gene expression on readministration to liver

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Evaluation of polyethylene glycol modification of first-generation and helper-dependent adenoviral vectors to reduce innate immune responses

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PEGylated helper-dependent adenoviral vectors: highly efficient vectors with an enhanced safety profile

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Sequestration of adenoviral vector by Kupffer cells leads to a nonlinear dose response of transduction in liver

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Selective depletion or blockade of Kupffer cells leads to enhanced and prolonged hepatic transgene expression using high-capacity adenoviral vectors

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Profiling the safety and tolerability of bisphosphonates

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Gadolinium chloride toxicity in the rat.

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Questions about systemic adenovirus delivery

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Preexisting immunity to adenovirus in rhesus monkeys fails to prevent vector-induced toxicity

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An enhanced system for construction of adenoviral vectors by the two-plasmid rescue method

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Improved system for helper-dependent adenoviral vector production

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Early-Onset Inflammatory ResponsesIn Vivoto Adenoviral Vectors in the Presence or Absence of Lipopolysaccharide-Induced Inflammation

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Effects of stuffer DNA on transgene expression from helper-dependent adenovirus vectors.

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TNFalpha and IFNgamma induced by innate anti-adenoviral immune responses inhibit adenovirus-mediated transgene expression

1 reference

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inferred from DOI database lookup

Update on adenovirus and its vectors

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Silencing TNFalpha activity by using Remicade or Enbrel blocks inflammation in whole muscle grafts: an in vivo bioassay to assess the efficacy of anti-cytokine drugs in mice

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based on heuristic

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Identifiers

10.1038/SJ.GT.3302792

1 reference

Europe PubMed Central

PubMed publication ID

26 July 2017

release_4u7mvdvy5vg45ijyy7utlwz5em

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https://api.fatcat.wiki/v0/release/4u7mvdvy5vg45ijyy7utlwz5em

24 November 2022

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PubMed publication ID

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Europe PubMed Central

PubMed publication ID

26 July 2017

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